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Isolamento Como Declaração de Recusa: Políticas Indígenas Contra A Violência do Estado Brasileiro
No full textPaired Housing or a Socially-Paired Context Decreases Ethanol Conditioned Place Preference in Male Rats
Get PDFAlcohol abuse dramatically affects individuals’ lives nationwide. The 2020 National Survey on Drug Use and Health (NSDUH) estimated that 10.2% of Americans suffer from alcohol use disorder. Although social support has been shown to aid in general addiction prevention and rehabilitation, the benefits of social support are not entirely understood. The present study sought to compare the benefits of social interaction on the conditioned ethanol approach behavior in rats through a conditioned place preference (CPP) paradigm in which a drug is paired with one of two distinct contexts. In experiment 1A, rats were single-housed and received conditioning trials in which ethanol was paired with the less preferred context. In experiment 1B, rats underwent procedures identical to experiment 1A, but were pair-housed throughout the paradigm. In experiment 1C, rats were single-housed, but concurrently conditioned to a socially-paired context and an ethanol-paired context. By comparing the time spent between the ethanol-paired environment and the saline-paired or socially-paired environment, we extrapolated the extent of ethanol approach behavior in the pair-housed, single-housed, and concurrently conditioned rats. Our results revealed that social interaction, both in pair-housed animals or concurrently socially-conditioned animals, diminished the ethanol approach behavior, which highlights the importance of social support in addiction prevention, treatment, and recovery programs
Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations
Get PDFThe self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, details of tau oligomer interactions with lipid rafts, a model of neuronal membranes, are not known. Using molecular dynamics simulations, the lipid-binding events, membrane-damage, and protein folding of tau oligomers on various lipid raft surfaces were investigated. Tau oligomers preferred to bind to the boundary domains (Lod) created by the coexisting liquid-ordered (Lo) and liquid-disordered (Ld) domains in the lipid rafts. Additionally, stronger binding of tau oligomers to the ganglioside (GM1) and phosphatidylserine (PS) domains, and subsequent protein-induced lipid chain order disruption and beta-sheet formation were detected. Our results suggest that GM1 and PS domains, located exclusively in the outer and inner leaflets, respectively, of the neuronal membranes, are specific membrane domain targets, whereas the Lod domains are non-specific targets, of tau oligomers binding to neurons. The molecular details of these specific and non-specific tau bindings to lipid rafts may provide new insights into understanding membrane-associated tauopathies leading to Alzheimer’s Disease
Censorship, Pandemic, and the Field of Power: The Death and Revival of a Chinese War Epic
Get PDFThis case study examines the dramatic change of fortune of the Chinese war epic “The Eight Hundred”. The movie was censored in 2019 during China’s celebration of the country’s 70th anniversary but became the market-saving hero in the wake of the COVID-19 pandemic in 2020. Through the lens of Bourdieu’s theory of the field of cultural production, this study argues that the movie’s changing fate is essentially the change of its political, symbolic and economic capitals, under different field conditions. The subfield of commercial films in China is subject to the control of political and economic forces in the field of power, but is also becoming an economic power itself
Unoriginality
Get PDFThis essay examines the importance of unoriginality in nineteenth-century American literature, showing how imitation and conventionality affirmed writers’ respectability and provided important legitimizing credentials. By way of illustration, this essay considers the career of Washington Irving, who presented himself as a guardian of literary tradition and repeatedly narrated the virtues of allowing the past to shape the future. As Irving’s career evidences, nineteenth-century readers did not particularly prize originality but instead found value in the familiar and conventional
Study Abroad Opportunities: The Impact Upon Learning
Get PDFSport businesses continue to grow beyond their borders. As a result, sport management programmes must prepare students to be more globally aware and culturally sensitive. This chapter presents an overview of the learning possibilities associated with short-term study abroad classes for sport management students. The importance of framing study abroad as a form of experiential learning is described. The chapter also includes a rationale for how short-term study abroad classes can provide access for student-athletes, students in tightly prescribed academic programmes, students for whom equity and access are important considerations, and others for whom a full semester programme might not be an option. Additionally, key research highlighting how short-term study abroad can positively impact intercultural awareness, global mindedness, intercultural competence, self-confidence, and levels of independence are presented
Preschool Children’s Processing of Events during Verb Learning: Is the Focus on People (Faces) or Their Actions (Hands)?
Get PDFVerbs are central to the syntactic structure of sentences, and, thus, important for learning one’s native language. This study examined how children visually inspect events as they hear, and do not hear, a new verb. Specifically, there is evidence that children may focus on the agent of the action or may prioritize attention to the action being performed; to date, little evidence is available. This study used an eye tracker to track 2-, 3-, and 4-year-olds’ looking to the agent (i.e., face) vs. action (i.e., hands) while viewing events linked to a new verb as well as distractor events. A Tobii X30 eye tracker recorded children’s fixations to AOIs (head/face and hands) as they watched three target events and two distractor events in different orders during the learning phase, and pointed to one of two events in two test trials. This was repeated for a second novel verb. Pointing results show that children in all age groups were able to learn and extend the new verbs to new events at test. Additionally, across age groups, when viewing target events, children increased their looking to the hands (where the action is taking place) as those trials progressed and decreased their looking to the agents’ face, which is less informative for learning a new verb’s meaning. In contrast, when viewing distractor events, children decreased their looking to hands over trials and maintained their attention to the face. In summary, children’s visual attention to agents’ faces and hands differed depending on whether the events cooccurred with the new verb. These results are important as this is the first study to show this pattern of visual attention during verb learning, and, thus, these results help reveal underlying attentional strategies children may use when learning verbs
Camaraderie, mentorship, and manhood: Contemporary Indigenous identities among the A’uwẽ (Xavante) of Central Brazil
Get PDFRites of passage and associated social processes and configurations can foster a sense of shared purpose, fraternity, and dedication to community through common experiences of group trials and commitment. A’uwẽ (Xavante) age organization entails the social production of manhood through a privileged form of male camaraderie constructed through age sets and mentorship, rooted in the shared experience of rites of passage and coresidence in the pre-initiate boys’ house. This process is central to how A’uwẽ men understand themselves, their social relations with certain delineated segments of society, and their ethnic identity. It is a basic social configuration contributing to the maintenance of A’uwẽ social and ethnic belonging in contemporary times. Ethnography of lowland South America could benefit from expanding its reach to consider the contributions of age organization and ritualized camaraderie to social and ethnic identity because they comprise an additional dimension of social identity that does not fit neatly into previously emphasized orders of social relations for this geographical region
