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Developing the Common Marmoset (\u3cem\u3eCallithrix jacchus\u3c/em\u3e) as a Model of Neurologic and Endocrine Aging
Get PDFThe Common marmoset (Callithrix jacchus) is a prominent translational neuroscience and geroscience model that presents promise as a model of human aging and neurodegenerative disease. Marmosets spontaneously exhibit age-associated phenotypes mirroring those of humans such as cognitive decline and amyloid deposition, and have the shortest lifespan among anthropoid primates, positioning the species for longitudinal study. The trajectory of cortisol across the marmoset lifespan was examined via measure of hair cortisol concentration (HCC) in a cohort of 50 captive animals subdivided into five age groups that span the entire marmoset lifespan. We found that infants exhibited higher HCC than all other age groups, females exhibited higher HCC than males, and an overall moderate negative correlation of cortisol with age across the marmoset lifespan. This suggests that marmosets do not display senescence and progressive dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis as they age. An ongoing 10-month pilot study aims to characterize aging profiles in a cohort of seven aged marmosets in terms of neuroinflammation, cognition, and neurodegenerative biomarkers. This will be done via parallel analysis of dynamic PET images using radiotracer [18F]-DPA-714 to quantify microglial activity, two cognitive tasks, and assessment of neurodegenerative blood biomarkers, including glial fibrillary acidic protein (GFAP), and pro-/anti-inflammatory cytokines. These projects aim to further our understanding of the aging process in the common marmoset, with the hope that these findings may be applied to future efforts using marmosets as an model of human aging, serving to identify risk factors for decline associated with aging, and elucidate the underlying mechanisms inherent in normal or pathological decline with age
The Political Nature of Arkady and Boris Strugatsky\u27s Roadside Picnic
No full textThe paper seeks to present to a general audience the historical and political context and significance of the book, Roadside Picnic, by Arkady and Boris Strugatsky, in contradiction to the claims made Boris about the book\u27s nature. To do so, the historical context of the book as well as popular political currents are examined, in tandem with the events and details of the narrative, synthesized with wider works about Soviet science fiction
A Short History of a Small Prep School
No full textThis creative nonfiction piece responds to the canon of literature commenting on academia. It centers around a problematic high school teacher and how his students respond to his atypical behavior within an institution that allows for such actions. In that vein, it contrasts how both he and the school want to appear against the harsh and often bizarre reality. Because the thesis is set primarily in an English class, I employed literary references to comment on the events of the narrative, ranging from Shakespeare to The Great Gatsby. More generally, the thesis comments on the inherent problems with private schools, and how a private school of an exceptionally small size fails to deliver on its promises
BMO on Shapes
Get PDFIn this thesis we prove that the space BMO on shapes introduced by Dafni and Gibara is the dual space of the Hardy Space on Shapes which we introduce here for the first time. This document is relatively self contained, building up the necessary background in measure theory, functional, and harmonic analysis
Identifying Providers as Agents of Change for Clinical-Based Interventions by Considering Provider\u27s Intrinsic Motivations and Capital
Get PDFThe theory of cultural health capital factors in a patient’s resources in their likelihood of accessing quality healthcare. The notion of quantifying a patient’s resources when researching equitable care, inadvertently places more of a focus on patient based interventions: policies focused on expanding a patient\u27s resources. Yet, I push past this approach and suggest studying practoner’s capital in parallel to patients as a better predictor of quality of care. Practitioner\u27s employ their own resources to make healthcare more equitable for underserved populations, and empowering clinicians to serve as agents of change in the patient-provider relationship takes the weight off of patients and allows practitioners to influence the quality of care patient’s experience
Review: Of Mixed Blood
Get PDFThe review revises the most inportant concepts of the book Of Mixed Blood
Does This Look Relevant to You? Using Insights from Information Retrieval Studies to Facilitate Student Source Selection, Reading, and Use
Get PDFNonhuman Animals and Hope: Kazuo Ishiguro’s Never Let Me Go and Philip K. Dick’s Do Androids Dream of Electric Sheep?
Get PDFWhat can critical animal studies learn by temporarily directing attention away from representations of nonhuman animals in literature? Kazuo Ishiguro\u27s Never Let Me Go and Philip K. Dick\u27s Do Androids Dream of Electric Sheep? allow readers to experience the hopes of engineered or artificial nonhuman creatures. Without presuming to know the unknowable or to make the animal speak, these novels help to further animal liberation discourses by democratizing the ostensibly human concept of hope, opening new paths of empathy between nonhuman and human animals while making it harder to accept the instrumentalization of nonhuman animals under anthropocentric capitalism
The Age of The Onanya - Regarding the spread of ayahuasca use throughout the Ucayali basin
Get PDFThe spread of ayahuasca shamanism throughout the Upper Amazon has become a matter of debate among scholars since, in 1994, anthropologist Peter Gow formulated the controversial suggestion that it could be a recent phenomenon in the Ucayali basin, usually considered the stronghold of a millenary tradition. Following Gow, Brabec de Mori argued that the Shipibo-Conibo people, a paradigmatic example of the antique practice of ayahuasca shamanism, adopted both the brew and the associated shamanic practices in a “relatively recent” past. Gow and Brabec pointed at the Maynas missions as the origin of this shamanic complex, and the mestizo and Cocama populations as the original diffusers throughout the Ucayali basin during the rubber boom. This article questions the arguments and data that Gow, Brabec, and others use to sustain this hypothesis—which has become the orthodoxy in contemporary anthropological research—by reviewing the historiographical sources and offering a different ethnographic interpretation and terminological analysis. In short: the hypothesis of a relatively recent spread of ayahuasca and/or ayahuasca shamanism throughout the Ucayali basin is not well founded, and a thorough analysis of the available sources points in the opposite direction
