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A Bacterial Vaccine Polypeptide Against Moraxella catarrhalis
No full textabstract: Moraxella catarrhalis is a gram negative commensal bacteria that is a primary cause of otitis media in infants and severe exacerbations of COPD in adults. M. catarrhalis treatment has become increasingly difficult and expensive over the past half-century due to the emergence of beta-lactamase producing strains. There are currently no vaccines available to protect against infections. In this paper, we propose a transcriptomics-based approach for identifying potential vaccine targets. Additionally, a novel method was used to create bacterial vaccine polypeptides composed of sequence conserved peptides secreted through the outer membrane. Polypeptides were tested for immunogenicity and protective capacity in mice. We show that relative abundance of outer membrane proteins does not correlate with immunogenicity. We also show promising results for polypeptide protection in a mouse pulmonary clearance model. (abstract
Differences in the Symptom Profile of Depression in South Asians
No full textabstract: The Beck Depression Inventory II (BDI-II) and the Patient Health Questionnaire 9 (PHQ-9) are highly valid depressive testing tools used to measure the symptom profile of depression globally and in South Asia, respectively (Steer et al., 1998; Kroenke et al, 2001). Even though the South Asian population comprises only 23% of the world’s population, it represents one-fifth of the world’s mental health disorders (Ogbo et al., 2018). Although this population is highly affected by mental disorders, there is a lack of culturally relevant research on specific subsections of the South Asian population.
As such, the goal of this study is to investigate the differences in the symptom profile of depression in native and immigrant South Asian populations. We investigated the role of collective self-esteem and perceived discrimination on mental health.
For the purpose of this study, participants were asked a series of questions about their depressive symptoms, self-esteem and perceived discrimination using various depressive screening measures, a self-esteem scale, and a perceived discrimination scale.
We found that immigrants demonstrated higher depressive symptoms than Native South Asians as immigration was viewed as a stressor. First-generation and second-generation South Asian immigrants identified equally with somatic and psychological symptoms. These symptoms were positively correlated with perceived discrimination, and collective self-esteem was shown to increase the likelihood of these symptoms.
This being said, the results from this study may be generalized only to South Asian immigrants who come from highly educated and high-income households. Since seeking professional help and being aware of one’s mental health is vital for wellbeing, the results from this study may spark the interest in an open communication about mental health within the South Asian immigrant community as well as aid in the restructuring of a highly reliable and valid measurement to be specific to a culture. (abstract
Sociocultural Effects on Women with MRKH Syndrome
No full textabstract: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disease that affects the female reproductive organs, causing them to be either malformed or completely absent. Much of the research regarding MRKH primarily focuses on the biological aspects of the disease and ignores the social impacts of the disease. I have conducted research to assess three of the underlying factors affecting women with the disease and gained a better understanding of how this disease affects these individuals and creates new obstacles for them throughout their lives. I found that for many women with MRKH, the decision to pursue treatment is greatly influenced by their environments and communities. Treatments range from something minor like vaginal dilation to much more controversial and riskier experimental treatments like uterine transplant surgery to experience pregnancy. Patients often experience “gender role insecurity� based on the cultural norms of their society. Gender role insecurity is the concern that gender norms may go unfulfilled, and even affects the relationships between women with MRKH and those who do not have the disease. This is a concern that women feel due to social pressures and standards. Gender role insecurity is important because it lets us understand what women with MRKH feel they lack in terms of their femininity and why medical intervention is so highly prioritized. Some societies and cultures with a more traditional background have a greater influence regarding the treatment options that MRKH women pursue. By analyzing support groups and online message boards, it seems that these support groups give women with MRKH the support and freedom to explore a range of treatment options, away from significant social pressures. (abstract
Pursuing Excellence: Frame Analysis of Zeta Upsilon, a Sigma Nu Chapter
No full textabstract: The thesis focuses on the opportunity of receiving the Rock Chapter Award as a chapter of Sigma Nu Nationals and analyzes it using Bolman and Deal’s Four Frames. An introduction to Sigma Nu, its programs, the Zeta Upsilon chapter, and guidelines brings into perspective how members and a chapter can earn a Rock Chapter Award. The introduction highlights the structural emphasis on the award and its achievement, however an analysis offers insights on how to further tighten the bolts within the structure and offer support by aligning members needs and skills with Rock Chapter criteria. A multi-frame approach is further supported by discussing the symbolism behind Rock Chapter and how it can be used as cohesion between the rigidity of the structure and the softness of the people. The frame analysis provided some solutions, which include adding a form of officer hours, increasing the effectiveness of the treasurer, and improving the culture of the weekly meetings. The four frames offer various insights into what is missing and how leadership can utilize assets, such as the resources of Sigma Nu and even Zeta Upsilon, to inspire the pursuit of excellence. Further, the four frames opens the door for leadership to better prepare for future Pursuit of Excellence Self-Assessments or operations by not being confined to one frame, which is useful to Zeta Upsilon as the chapter has been conditioned to rely on a structural approach during its short time back on Arizona State’s campus. (abstract
Adverse Side Effects of Pharmacological Agents for Pediatric Anxiety Disorders: A Critical Review
No full textabstract: Pediatric anxiety disorders are highly prevalent and while pharmacological intervention seems to be an effective treatment, the validity of reported adverse side effects remains unclear.
Objective: To analyze the nature of evidence regarding adverse side effects in the pharmacological treatment of pediatric anxiety disorders.
Approach: A search using Google Scholar, PubMed, and PsychInfo was conducted for meta-analyses of pharmacological treatment of pediatric anxiety disorders as well as randomized controlled trials. The focus was on adverse events.
Results and Conclusion: Reportings of a limited number of adverse events were found among resources available to clinician and patient informed sources to inform pharmacological treatment of pediatric anxiety disorders. Only a small fraction of adverse side effects were found in the research literature. This finding raises concerns about making informed decisions to treat pediatric anxiety disorders with pharmacotherapy. (abstract
Modern Threats to American Democracy: A Study of 21st-Century Declines in Civic Engagement
No full textabstract: This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to civic engagement. It provides a socio-legal framework for evaluating four phenomena that have shifted in their impact on politics over the past 20 years: the roles of money and media in politics, as well as disenfranchisement by gerrymandering and by felon voting restrictions. It demonstrates how each has a new and worsening impact on voter education and/or participation, thus threatening the continued existence of modern American democracy. (abstract
Emily and friends vol. III
No full textJohann Sebastian BachFrancis PoulencPaul HindemithAstor Piazzolla, arr. Morten Hochliene
Zoning and Community Health: A Case Study into Natural Gas Extraction in Pennsylvania
No full textabstract: Natural gas development in the Northern Appalachian region has skyrocketed dramatically over the past decade. Correspondingly to the unprecedented growth rate of the natural gas industry, population health risks have shifted dramatically in response to both aerial and water pollution. With energy as a key input in all sectors of Appalachian life, the Pennsylvania region serves as a fascinating case study where clusters of unconventional gas drilling wells intersect varying population densities and governing laws to create different levels of health risks. Studies have found that horizontal hydraulic fracking corresponds to an increased risk of upper respiratory symptoms (URS), low birth weights, premature births, and certain cancers (White et al., 2009). Also, zoning and local planning laws are policy tools local governments can use to directly influence community wellbeing (Diez-Roux, 2011). This study will focus on the spatial relationship between upper respiratory symptoms (URS), a key volatile health benchmark, and the zoning/planning laws that the Oil and Natural Gas Industry must adhere to. Our project seeks to provide a preliminary understanding of the interplay between different natural gas zoning laws and the resulting health implication risks that appear in the Marcellus shale region of Pennsylvania. This is necessary to appropriately regulate and monitor hydraulic fracking. To get a better understanding of this phenomenon, spatial autocorrelation and analysis of variance statistics are integrated to generate a surface-level understanding of areas impacted by natural gas development. To guide the creation of our models, we geographically process the unconventional well locations, upper respiratory symptom health utilization, and zoning law data to develop insights that policymakers can take into consideration. Regionally, natural gas has become an integrated part of the energy sector and a driver of local economic development. The patterns drawn from this assessment provide a novel way of understanding the population health risks posed by different zoning ordinance models. (abstract
American Logistics Aid Network Process Improvement and Optimization Project
No full textabstract: American Logistics Aid Network (ALAN) is a non-profit logistics aid firm that provides supply chain assistance to non-profit organizations in times of crisis. It acts somewhat as a non-profit 3PL, connecting nonprofits seeking humanitarian aid goods, materials handling equipment, warehousing, logistics transportation, and expertise to an outstanding network of partner companies and organizations who help to deliver on their requests. In June of 2020, our team began an internship to identify and implement key process improvements for ALAN’s internal and external processes. This thesis is a summary of our findings, our solutions proposal, and their applicability to other non-profit organizations