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Non-invasive PCO2 monitoring during polysomnography: transcutaneous versus end-tidal measurement
No full textPURPOSE: The objectives of this study were to monitor transcutaneous and end-tidal partial pressures of CO(2) simultaneously during polysomnography, determine the advantages and disadvantages of each method, and identify relevant factors that can affect the results. METHODS: This cross-sectional study enrolled 55 adults who underwent polysomnography at the Ajou University Hospital Sleep Center between February 2021 and September 2022. They were volunteers who spontaneously breathed room air. Polysomnography reports, including those of CO(2) monitoring, of all participants were reviewed and analyzed by sleep experts. Generalized Estimation Evaluation, Bon Ferroni Post Hoc and multivariable regression analysis were used for statistical analysis. RESULTS: Throughout all sleep stages, the mean, highest, and lowest values of end-tidal and transcutaneous partial pressure of CO(2) showed significant differences. The mean transcutaneous partial pressure was higher than the mean end-tidal partial pressure by 2.53 mmHg. The apnea index, apnea-hypopnea index, and height were significant factors affecting the difference between the mean transcutaneous and end-tidal partial pressure of CO(2). As the obstructive sleep apnea grade increased, the mean end-tidal CO(2) partial pressure value decreased. Two patients had hypoventilation; one met the criteria based on the transcutaneous partial pressure of CO(2) and the other met those based on the end-tidal partial pressure of CO(2). CONCLUSION: During diagnostic sleep studies, the application of both transcutaneous and end-tidal measurements is suggested for stable and accurate monitoring of partial pressure of CO(2) and complementary analysis
Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose
No full textOBJECTIVES: This study aims to review the long-term outcome of congenital hypothyroidism (CH) and whether patient- or treatment-related factors impact the outcomes, especially focusing on the initial Levothyroxine dose. METHODS: This is a retrospective, cross-sectional study of the children diagnosed with CH who received Levothyroxine at Ajou University Hospital between 2003 and 2024. Comparative analysis was performed between the low (<10 mcg/kg) and high (>/=10 mcg/kg) initial dose groups. Repeated-measures analysis of covariance was employed to evaluate longitudinal changes in growth outcomes, and multivariate linear regression was utilised to evaluate the effects of clinical factors on the intelligence quotient (IQ). RESULTS: Among the study population, 84 of 144 children were prescribed an initial low dose of Levothyroxine. Most children in both initial dose groups showed appropriate growth within the normal range in the biennial growth evaluation from ages four to eight and in the Wechsler IQ exam. The initial dose seemed to not significantly affect the growth outcomes over time, as no significant differences between the low- and high-dose groups were observed (p values: 0.545, 0.609, 0.532, and 0.501 for bone age-chronological age, height z-score, weight z-score, and BMI z-score, respectively). The effect of the initial dose group on the full-scale IQ was also not statistically significant (p = 0.362). CONCLUSION: We demonstrated the favourable long-term outcomes in linear growth and neurodevelopment among children with CH, even in lower initial Levothyroxine doses
Mobile Versus Fixed-Bearing in Medial Unicompartmental Knee Arthroplasty: An Average 10-Year Follow-Up
No full textBackground: Unicompartmental knee arthroplasty (UKA) represents a well-recognized treatment option for isolated medial compartment osteoarthritis; however, the debate regarding the superiority of fixed-bearing versus mobile-bearing designs continues. We aimed to evaluate the mid- to long-term outcomes of medial UKA comparing mobile- versus fixed-bearing designs within a single institution over an average 10-year follow-up. Methods: This retrospective study included 81 consecutive patients who underwent primary medial UKA (45 fixed-bearing and 36 mobile-bearing) with a minimum five-year follow-up. Clinical outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and range of motion (ROM). Radiological measurements included hip-knee-ankle axis angle (HKA) and osteoarthritis progression. Implant survivorship was evaluated using Kaplan-Meier analysis, with failure defined as either conversion to total knee arthroplasty (TKA) or polyethylene (PE) exchange. Results: At a mean follow-up of 10.6 years, WOMAC scores, ROM, and radiological outcomes showed no statistically significant differences between the fixed-bearing and mobile-bearing groups. Significantly higher failure rates were observed in the mobile-bearing group, both when considering conversion only (p = 0.041) and when including conversion or PE exchange (p = 0.009). Survival analysis demonstrated 10-year rates of 97.8% for fixed-bearing and 88.9% for mobile-bearing with TKA conversion defined as failure (p = 0.066). Using combined failure criteria of TKA conversion or PE exchange, 10-year survival rates were 97.8% for fixed-bearing and 83.3% for mobile-bearing (p = 0.015). Conclusions: At a mean 10.6-year follow-up, clinical and radiological outcomes were comparable, but fixed-bearing UKA demonstrated superior survivorship
Three-Dimensional Culture of Epithelial Cells on Electrospun Nanofibrous Scaffolds
No full textEpithelial tissues form protective barriers throughout the body, covering external surfaces and lining internal cavities. Nanofibrous scaffolds have emerged as leading platforms in tissue engineering because of their ability to mimic the nanoscale fibrillar architecture of the native extracellular matrix. Thus, they support the optimal microstructure and cellular functions that facilitate the generation of epithelial tissues. This review focuses on the pivotal role of nanofibrous scaffolds in the development of physiologically relevant three-dimensional (3D) culture systems for various types of epithelial cells. Nanofiber proper ties, including diameter, alignment, and surface chemistry, can be tailored to modulate epithelial cell attachment and growth on scaffolds. Fabrication techniques and optimized scaffold properties for culturing epithelial cells from various epithelial tissues on nanofibrous scaffolds have been examined. The key 3D culture methodologies and coculture systems that incorporate fibroblasts, endothelial cells, and immune cells, which are essential for achieving functional differentiation into an epithelium, are elucidated. Finally, the current challenges in this field and potential future directions, including the integration of scaffolds into organ-on-a-chip systems, development of "smart" bioactive materials, and pursuit of personalized medicine through patient-derived cells, are discussed
복식호흡 중재가 노인 수술 환자의 불안, 통증에 미치는 효과
No full textMasterⅠ. 서론 1
A. 연구의 필요성 1
B. 연구 목적 3
C. 연구 가설 3
D. 용어 정의 4
Ⅱ. 문헌고찰 6
A. 복식호흡의 생리학적 기전 6
B. 복식호흡이 불안에 미치는 효과 7
C. 복식호흡이 수술 후 통증에 미치는 효과 8
D. 노인환자 수술 전 교육 10
Ⅲ. 연구 방법 13
A. 연구 설계 13
B. 연구 대상 14
C. 연구 도구 15
D. 자료수집방법 16
E. 자료분석방법 21
Ⅳ. 연구 결과 23
A. 실험군과 대조군의 사전동질성 검증 23
B. 가설검증 25
Ⅴ. 논의 30
Ⅵ. 결론 및 제언 36
참고문헌 38
부록 42
ABSTRACT 5
임상간호사의 투약안전역량, 이차피해경험, 이차피해지지, 업무관련 부정적 결과의 관계
No full textMasterⅠ. 서론 1
A. 연구의 필요성 1
B. 연구의 목적 4
C. 용어의 정의 5
Ⅱ. 문헌고찰 7
A. 임상간호사의 투약안전역량 7
B. 임상간호사의 이차피해경험, 이차피해지지, 업무관련 부정적 결과 9
Ⅲ. 연구방법 13
A. 연구설계 13
B. 연구대상 13
C. 연구도구 14
D. 자료수집 기간 및 방법 17
E. 윤리적 고려 17
F. 자료분석방법 18
Ⅳ. 연구 결과 19
A. 연구 대상자의 특성 19
B. 투약안전역량, 이차피해경험, 이차피해지지, 업무관련 부정적 결과 정도 23
C. 일반적 특성에 따른 투약안전역량, 이차피해경험, 이차피해지지, 업무관련 부정적 결과의 차이 25
D. 투약안전역량, 이차피해경험, 이차피해지지, 업무관련 부정적 결과 간의 관계 28
Ⅴ. 논의 33
Ⅵ. 결론 및 제언 43
A. 결론 43
B. 제언 44
참고문헌 4
병동간호사의 환자안전간호활동에 영향을 미치는 요인
No full textMasterⅠ. 서론 1
A. 연구의 필요성 1
B. 연구의 목적 4
C. 용어의 정의 5
Ⅱ. 문헌고찰 7
A. 환자안전간호활동 7
B. 환자안전간호활동 영향요인 10
Ⅲ. 연구방법 14
A. 연구설계 14
B. 연구대상자 14
C. 연구 도구 15
D. 자료수집방법 17
E. 윤리적 고려 17
F. 자료분석방법 18
Ⅳ. 연구결과 19
A. 대상자의 일반적 특성 19
B. 대상자의 환자안전문화, 간호전문직관 및 환자안전간호활동의 정도 21
C. 대상자의 일반적 특성에 따른 환자안전간호활동의 차이 23
D. 대상자의 환자안전간호활동, 환자안전문화, 간호전문직관 간의 상관관계 25
E. 대상자의 환자안전간호활동에 영향을 미치는 요인 27
Ⅴ. 논의 29
A. 일반병동 간호사의 환자안전간호활동, 환자안전문화, 간호전문직관 29
B. 일반병동 간호사의 환자안전간호활동 영향요인 34
C. 연구의 의의 및 제한점 36
Ⅵ. 결론 및 제언 37
A. 결론 37
B. 제언 38
참고문헌 39
부 록 48
ABSTRACT 5
비외과적 치주치료 이후 구강건강에 영향을 미치는 요인 분석
No full textMasterⅠ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 3
A. Study population 3
B. Non-surgical periodontal therapy 5
C. Supportive periodontal therapy 6
D. Clinical assessment 6
E. Statistical analysis 10
Ⅲ. RESULTS 11
A. Demographics 11
B. Changes in clinical parameters during supportive periodontal therapy 11
C. Pocket closure 13
D. Clinical endpoint 18
E. Extraction due to periodontitis 28
Ⅳ. DISCUSSION 35
Ⅴ. CONCLUSION 40
REFERENCES 41
국문요약 4
선택적 COX-2 억제제 사용과 자궁내막증 발생의 연관성
No full textMasterⅠ. 서론 1
Ⅱ. 재료 및 방법 3
A. 데이터 수집 3
B. 연구 설계 4
C. 연구 대상 및 코호트 구조 4
D. 약물 사용의 조작적 정의 6
E. 결과 측정 기준 7
F. 통계 분석 8
G. 민감도 분석 9
H. 데이터 보간 10
Ⅲ. 결과 10
A. 연구 대상 및 기초 특성 10
B. 약물 처방과 자궁내막증 발생 간의 연관성 14
C. 하위 그룹 및 민감도 분석 17
Ⅳ. 고찰 23
Ⅴ. 결론 24
26
3
High BMI(Body Mass Index)로 인한 전 세계 질병 부담 및 2040년까지의 예측 : Global Burden of Disease Study 2019 기반의 연구
No full textMasterⅠ. 서론 1
A. 연구의 필요성1
B. 연구의 목적 4
C. 선행 연구5
Ⅱ. 이론적 배경 8
A. BMI(Body Mass Index)8
B. GBD(Global Burden of Disease Study)11
Ⅲ. 연구 방법 14
A. 연구 자료14
B. 추세 관련 분석 방법 16
C. 예측 관련 분석 방법 18
Ⅳ. 연구 결과 21
A. 추세 결과21
1. High BMI로 인한 전 세계 질병 부담 22
2. High BMI로 인한 성별 및 연령별 질병 부담23
3. High BMI로 인한 SDI별 질병 부담 24
4. High BMI로 인한 세계보건기구(WHO) 지역별 질병 부담25
5. High BMI로 인한 질병 Level별 질병 부담 30
6. High BMI로 인한 전 세계 지역의 DALYs 분포37
B. 예측 결과39
1. High BMI로 인한 성별 질병 부담 예측 40
2. High BMI로 인한 연령별 질병 부담 예측43
Ⅴ. 논의 47
Ⅵ. 결론 및 제언 51
참고문헌 53
ABSTRACT 5