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재가장기요양서비스 이용 노인의 삶의 의미 영향요인: 서술적 단면 조사 연구
Get PDFPurpose: The purpose of this study was to investigate the effects of activities of daily living, depres-sion, and social support on the meaning in life in older adults using services under the long-term care insurance system. Methods: This was a cross-sectional study. A total of 121 older adults were recruit-ed from seven senior daycare centers in two cities in Korea. Data collection was performed between September and October 2023. The data were analyzed using descriptive statistics, t-tests, ANOVA, Pearson correlation coefficients, and hierarchical multiple regression analysis. Results: The results of this study showed that social support (β=.45, p<.001) and depression (β=-.16, p=.048) were signifi-cantly affecting factors to the meaning in life in older adults using services under the long-term care insurance system. Conclusion: Efforts to enhance social support and reduce depressive symptoms are critical to improve the meaning in life of older adults utilizing services under the long-term care insurance system. Specifically, it is necessary to closely identify older adults’ depressive symptoms and further strengthen social support, including policy support and individualized support from healthcare professionals in the facilities to improve older adults’ meaning in life
비알코올성 지방간 질환의 비침습적 평가를 통한 중증도 변화와 당뇨 발병 간의 관계
No full textDoctorI. INTRODUCTION 1
II. METHODS 3
A. Study population 3
B. Definition of terms 4
C. Anthropometric and laboratory evaluation 6
D. Statistical analysis 7
III. RESULTS 8
A. Baseline characteristics of the subjects 8
B. Risk factors for developing incident DM 9
C. Comparison of the risk of developing incident DM according to change pattern of HSI and metabolic associated fatty liver disease (MAFLD) 10
D. Comparison of the risk of developing incident DM according to change pattern of BMI and HOMA-IR, Fibrosis-4 score 11
E. Comparison of discriminatory ability for predicting incident DM among the change patterns of HSI, BMI and HOMA-IR over time 12
F. Comparison of discriminatory ability for predicting incident DM among the change patterns of HSI and MAFLD over time in MAFLD population 13
G. Comparison of discriminatory ability for predicting incident DM between change pattern of HSI over time and NAFLD development at a single time point 14
IV. DISCUSSION 26
V. CONCLUSION 31
VI. REFERENCE 32
VII. SUPPLEMENTARY APPENDIX 38
VIII. 국문요약 4
Impact of spinal injury on mortality in patients with major trauma: A propensity-matched cohort study
No full textDoctorI . Introduction 1
II . Materials and Methods 3
A. Study Design and Population 3
B. Propensity Score Matching and Outcomes 6
C. Statistical Analysis 7
III . Results 8
A. Baseline Characteristics 8
B. Comparison of Mortality and Cause of death between Propensity-Score-Matched groups 9
C. Kyphotic Progression in Survivors of the Spinal injury group 13
IV. Discussion 15
A. Limitations of ISS 15
B. Mechanisms of Injury 17
C. Mortality 19
D. Kyphotic Progression 21
E. Stregths and Limitations 22
V. Conclusion 24
References 2
코로나 19 유행 전과 유행 초기 지역사회 노인의 노쇠 유병률 변화와 관련 요인
No full textMasterⅠ. 서론 1
1. 연구의 필요성 1
2. 연구의 목적 3
Ⅱ. 이론적 배경 4
1. 코로나 19 4
2. 노쇠 6
Ⅲ. 연구 방법 8
1. 연구대상 8
2. 연구모형 및 연구가설 10
3. 변수의 정의 12
4. 자료분석방법 19
Ⅳ. 연구 결과 20
1. 연구 대상자의 일반적 특성과 차이 20
2. 코로나 19 유행 전과 유행 초기의 노쇠 유병률의 변화와 차이 26
3. 코로나 19 유행 전과 유행 초기의 특성 별 노쇠 수준의 차이 28
4. 코로나 19 유행 전 대비 유행 초기의 노쇠 유병률과의 관련성 36
5. 코로나19 유행 전 대비 유행 초기의 일반적 특성과 노쇠 유병률의 변화와의 관련성 38
Ⅴ. 고찰 56
1. 노쇠 유병률의 변화 56
2. 코로나 19 유행 전과 유행 초기 노쇠 유병률의 상승과 관련 요인 59
Ⅵ. 결론 68
참고문헌 69
부록 84
ABSTRACT 10
응급실 간호사의 아동학대 신고의도 영향 요인
No full textMasterⅠ. 서론 1
A. 연구의 필요성 1
B. 연구의 목적 4
C. 용어의 정의 4
Ⅱ. 문헌고찰 7
A. 응급실 간호사의 아동학대 신고의도 7
B. 응급실 간호사의 아동학대 신고의도 영향 요인 9
Ⅲ. 연구 방법 13
A. 연구 설계 13
B. 연구 대상자 13
C. 연구 도구 14
D. 자료수집방법 16
E. 자료분석방법 17
F. 윤리적 고려 17
Ⅳ. 연구 결과 18
A. 대상자의 일반적 특성 18
B. 대상자의 아동학대에 대한 인식, 신고 태도, 도덕적 민감성과 아동학대 신고의도 20
C. 일반적 특성에 따른 아동학대 신고의도의 차이 22
D. 아동학대에 대한 인식, 신고 태도, 도덕적 민감성과 아동학대 신고의도 간의 관계 24
E. 아동학대 신고의도에 영향을 미치는 요인 26
Ⅴ. 논의 28
A. 응급실 간호사의 아동학대 신고의도, 아동학대에 대한 인식, 신고태도와 도덕적 민감성 정도 28
B. 응급실 간호사의 아동학대 신고의도 영향요인 31
C. 연구의 의의 및 제한점 34
Ⅵ. 결론 및 제언 36
A. 결론 36
B. 제언 37
참고문헌 38
부 록 44
ABSTRACT 4
항체표지 없이 세포질 내로 유입된 항체를 정량하는 방법
No full textMasterⅠ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 16
A. Plasmid construction 16
B. Lentivirus packaging 16
C. Cell culture 17
D. Lentiviral transduction 17
E. Western blot 18
F. Firefly luciferase assay with removing cell culture medium 18
G. Firefly luciferase assay without removing cell culture medium 18
Ⅲ. RESULT 20
Ⅳ. DISCUSSION 34
Ⅴ. CONCLUSION 37
REFERENCES 38
국문요약 4
경기도 자동심장충격기의 설치 및 사용과 사회경제적 수준의 연관성 분석
No full textMasterⅠ. 서론 1
1. 연구의 필요성 1
2. 연구 목적 4
Ⅱ. 연구방법 4
1. 연구 자료 4
2. 변수 선정 및 정의 10
3. 통계적 분석 12
Ⅲ. 연구 결과 13
1. 경기도 시·군·구별 일반적 특성 13
2. 경기도 시·군·구별 자동심장충격기 설치 장소별 현황 17
3. 경기도 시·군·구별 지역주민 자동심장충격기 사용 현황 20
4. 경기도 시·군·구별 응급실 내원 심정지 환자 생존율 차이 21
5. 경기도 시·군·구별 자동심장충격기 설치 및 사용과 심정지 환자 발생 연관성 26
6. 경기도 시·군·구별 사회경제적 수준에 따른 자동심장충격기 설치 및 사용 연관성 30
Ⅳ. 고찰 39
Ⅴ. 결론 및 제언 44
참고문헌 46
ABSTRACT 5
Robust Symptomatic Subtypes of Typical Alzheimer’s Disease Characterized by Differential Neuropathological Patterns and Functional Decline
No full textBACKGROUND: Alzheimer's disease (AD) is classically viewed as a predominantly amnestic syndrome, with other cognitive and neuropsychiatric symptoms (NPS) being non-integral associations. Emerging Evidence suggests that within typical AD, these symptoms are core features from the onset. METHODS: We employed K-modes clustering on 2483 cognitively impaired (CI) individuals (CDR ≥ 0.5), excluding participants diagnosed with atypical AD, non-amnestic MCI, or CI due to non-AD dementias from five cohorts: TRIAD, ADNI, BICWALZS, OASIS-III, and Pittsburgh. Cluster-specific clinical and pathological profiles were established through comparison with 2670 cognitively unimpaired (CU) participants across plasma biomarkers (Ptau-181, Ptau-217, GFAP, Nfl, AB42/40 ratio) and neuroimaging (amyloid and tau PET, white matter hyperintensity, MRI-derived degeneration maps). The rate of functional decline, modeled by increase in CDR-SB, was assessed using a Cox-proportional hazards model and a linear mixed-effect model. RESULTS: We identified five distinct clinical phenotypes within typical AD: 'Pure Amnestic' (30.2%), 'Linguistic-Hyperactive' (14.7%), 'Visuospatial-Affective' (14.7%), 'Frontal' (27.6%), and 'Global' (19.3%) (Figure 1, Figure 3). These phenotypes demonstrated consistency regardless of amyloid status or cohort. Each phenotype exhibited a unique neuropathological signature and a distinct pattern of neurodegeneration (Figure 2). A critical aspect of our findings is the differential rate of functional decline across these phenotypes. The 'Pure Amnestic' group showed the slowest decline, followed by 'Linguistic-Hyperactive' (HR = 1.39; B = 0.2), 'Visuospatial-Affective' (HR = 2.13; B = 1), 'Frontal' (HR = 2.23; B = 1.53), and the 'Global' phenotype showing the fastest decline (HR = 3.52; B = 2.66) (Figure 2, Figure 3). CONCLUSION: Our results challenge the concept of "typical" AD by uncovering five robust clinical phenotypes with divergent neuropathological profiles and clinical characteristics. These results mark an important advancement toward personalized medicine in the landscape of emerging AD treatments
Contribution of monocyte and macrophage extracellular traps to neutrophilic airway inflammation in severe asthma
Get PDFBackground: Increased blood/sputum neutrophil counts are related to poor clinical outcomes of severe asthma (SA), where we hypothesized that classical monocytes (CMs)/CM-derived macrophages (Mφ) are involved. We aimed to elucidate the mechanisms of how CMs/Mφ induce the activation of neutrophils/innate lymphoid cells (ILCs) in SA. Methods: Serum levels of monocyte chemoattractant protein-1 (MCP-1) and soluble suppression of tumorigenicity 2 (sST2) were measured from 39 patients with SA and 98 those with nonsevere asthma (NSA). CMs/Mφ were isolated from patients with SA (n = 19) and those with NSA (n = 18) and treated with LPS/interferon-gamma. Monocyte/M1Mφ extracellular traps (MoETs/M1ETs) were evaluated by western blotting, immunofluorescence, and PicoGreen assay. The effects of MoETs/M1ETs on neutrophils, airway epithelial cells (AECs), ILC1, and ILC3 were assessed in vitro and in vivo. Results: The SA group had significantly higher CM counts with increased migration as well as higher levels of serum MCP-1/sST2 than the NSA group. Moreover, the SA group had significantly greater production of MoETs/M1ETs (from CMs/M1Mφ) than the NSA group. The levels of MoETs/M1ETs were positively correlated with blood neutrophils and serum levels of MCP-1/sST2, but negatively correlated with FEV1%. In vitro/in vivo studies demonstrated that MoETs/M1ETs could activate AECs, neutrophils, ILC1, and ILC3 by increased migration as well as proinflammatory cytokine production. Conclusions: CM/Mφ-derived MoETs/M1ETs could contribute to asthma severity by enhancing neutrophilic airway inflammation in SA, where modulating CMs/Mφ may be a potential therapeutic option