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티아졸리디논 화합물 및 그의 용도
No full text[[abstract]]화학식 (I)의 화합물을 함유하는 오피오이드 수용체-관련 증상 치료용 약학 조성물이 개시된다. 또한, 상기 화합물을 사용하여 오피오이드 수용체-관련 증상을 치료하는 방법이 개시된다. 화학식 (I)의 티아졸리디논 화합물 두 세트: (i) 각각 90% 초과의 거울상이성질체 과잉율을 갖는 화합물, 및 (ii) 각각 중수소로 치환된 화합물이 또한 개시된다
Thiazolidinone compounds and use thereof
No full text[[abstract]]A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium
[[alternative]]Thiazolidinone compounds and use thereof
No full text[[abstract]]一種包含式(I)化合物之用於治療鴉片受體相關病症之醫藥組成物，也揭露了使用這種化合物治療鴉片受體相關病症之方法，進一步揭露兩組式(I)之噻唑烷酮化合物：(i)各自具有大於90%鏡像超越值之化合物以及(ii)各自經氘取代之化合物
Pyrrolidine derivatives
No full text[[abstract]]Disclosed are pyrrolidine compounds of formula (I), wherein the variables are as defined in the specification, these pyrrolidine compounds inhibit dipeptidyl peptidase IV and are suitable for treating Type II diabetes
Pyrrolidine derivatives
No full text[[abstract]]Pyrrolidine compounds described herein and methods for using them to inhibit dipeptidylpeptidase IV and treat Type II diabetes
Composto
No full text[[abstract]]COMPOSTO E MÉTODO DE TRATAMENTO DE DIABETES DO TIPO II. A presente invenção refere-se aos compostos de pirrolidina descritos e aos métodos para sua utilização para a inibição de dipeptidil peptidase IV e o tratamento de diabetes tipo II
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) promotes progression of triple negative breast cancer
No full text[[abstract]]Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), which is encoded by PCK2, is up-regulated in various tumors, including breast cancer (BC). The role of PEPCK-M in the pathogenesis and progression of BC is largely unknown. Recently, we found that PEPCK-M is differentially expressed in BCs. High expression of PEPCK-M was noted in around half of triple negative BC (TNBC). We evaluated the function of PEPCK-M in TNBC. Knockdown of PCK2 reduced the proliferative rate of TNBC cells and delayed the cell cycle progression to S phase. In addition, knockdown of PCK2 attenuated invasion and migration of TNBC cells with reduced expression of smad3, snail-1 and slug. PCK2 positively regulated smad3 at transcriptional level. Knockdown of smad3 reduced expression of snail-1 and slug. In addition, knockdown of PCK2 attenuated the stimulatory effect of TGF-beta to smad3 phosphorylation in TNBC cells. Taken together, PCK2 not only promotes cell proliferation and cell cycle progression of TNBC but also promotes tumor invasion/migration via regulation of smad3. The result suggests that PEPCK-M may be a potential therapeutic target for the treatment of TNBC
Transitional probabilities shape the learning brain: Electrophysiological evidence of nonlinguistic statistical learning
No full textGender difference on the mediation effects of filial piety on the association between chronic obstructive pulmonary disease and depressive symptoms in older adults
No full text[[abstract]]Background: Filial piety is viewed as a strong family support for Chinese people and is strongly associated with depressive symptoms. It is unknown if gender and filial piety could mediate the relationship between chronic obstructive pulmonary disease (COPD) and depression. There is a strong association between COPD and depressive symptoms; however, the mediating effect of filial piety, a form of social support, on this association is unknown. Since deterioration of lung function can be an indicator of COPD and there is a gender difference in the effects of social support, we hypothesized that pulmonary function is inversely related to depression, and the relationship is mediated by filial piety differently by gender. Aims & Objectives: We aim to investigate whether filial piety mediates the association between lung function and depression in community-dwelling older people by using the Data from The Healthy Aging Longitudinal Study in Taiwan (HALST). Method: Data for this study were from the HALST, which is a longitudinal study recruiting people aged 55 and above from seven selected communities in Taiwan. A total of 5664 participants were enrolled in the first wave of the study since October 2008. We analyzed data from the second wave which started in 2013. Pulmonary function was taken between 2016 and 2019; only Community dwelling adults aged 65 and above were analyzed in this study. Pulmonary function, depressive symptoms, and filial piety expectation (FPE) and receipt of filial piety (RFP) were collected. The interaction and mediation of filial piety between lung function and depression was analyzed. Results: In older men, forced expiratory volume in the first second (FEV1) was inversely correlated with depression (β = -0.1452, p = 0.001) with no mediation effect of FPE. In older women, FEV1 was negatively associated with FPE, but FPE did not increase the risk of depression (β = 0.0713, p = 0.07). In both older men and women, FEV1 was negatively associated with RFP, while RFP reduced the risk of depression (p< 0.001). In older women, the correlation between FEV1 and depression was not statistically significant with complete mediation of RFP. Discussion & Conclusion: This is the largest study to assess gender difference of mediation effect of filial piety on the relationship between lung function and depressive symptoms in a community-dwelling elderly population. Our results suggested that PRFP independently modified the association of FEV1 and depression in both sexes. After controlling for possible covariates, PRFP was negatively correlated with depression symptoms. In older men, PRFP had a partial mediation effect on the relationship between FEV1 and depression, whereas PRFP had a complete mediation effect on older women. Feelings of insufficient filial piety may increase the likelihood of depression, especially in older women with worse lung function