13856 research outputs found
Sort by
Specimen preparation for transmission electron microscopy
No full text[[abstract]]A TEM specimen kit is disclosed, which comprises: (a) a top substrate and a bottom substrate, the top and the bottom substrates being transparent and substantially parallel to each other; (b) a first spacer and a second spacer, located beneath the top substrate and sitting on the bottom substrate, the second spacer being opposite to and spaced apart from the first spacer at a distance of d; and (c) a chamber formed between the top and bottom substrate and between the first and second spacer, the chamber having two ends open to the atmosphere and characterized by having a height defined by the thickness h of the spacer, wherein the height being smaller than the diameter of a red blood cell. Also enclosed are methods for preparing a dry specimen for TEM nanoparticle characterization, and methods for analyzing TEM images of nanoparticles in a liquid sample
[[alternative]]Laser speckle contrast imaging system and laser speckle contrast imaging method thereof
No full text[[abstract]]一種雷射光斑對比成像系統，包含有一雷射光源，用來發射一雷射光束照射一物體；複數個可見光源，用來分別發射一可見光束照射該物體；一影像擷取模組，用來獲得對應於該雷射光束照射該物體之一第一影像，以及獲得對應於該複數個可見光束照射該物體之複數個第二影像；以及一影像處理器，耦接至該影像擷取模組，用來以一雷射光斑堆疊演算法處理該第一影像，以根據該第一影像中所決定之至少一光斑點，決定一皮質傳播抑制波形之一變化
[[alternative]]Imidazolidinone compounds
No full text[[abstract]]一種具有下式之化合物：其中R1、R2、R3、T、W、m、x與y皆如說明書中所定義。亦揭示一種使用上述化合物治療腸病毒感染之方法。A compound having the formula: in which R1, R2, R3, T, W, m, x, and y are defined as in the specification. Also disclosed is a method of treating enterovirus infection by using a compound described above
[[alternative]]Pharmaceutical compositions for preventing or treating disorders associated with bacterial or viral infection
No full text[[abstract]]本發明係關於一種用於預防或治療與細菌或病毒感染有關病症之醫藥組合物，包括醫療有效量之水溶性富勒烯衍生物(fullerene derivative)之混合物或一種水溶性富勒烯衍生物，或其醫藥上可接受溶劑合物或鹽，合併醫藥上可接受載劑。The present invention relates to a pharmaceutical composition for use in preventing or treating disorders associated with bacterial or viral infection, comprising a therapeutically effective amount of a mixture of water-soluble fullerene derivatives or a water-soluble fullerene derivative, or a pharmaceutically acceptable solvate or salt thereof, in combination with a pharmaceutically acceptable carrier
付加的抗うつ剤組成物及びその使用方法
No full text[[abstract]]The present invention relates to a method for decreasing the psychotomimetic side effects and enhancing the antidepressant-like effects of ketamine by the combination of ketamine with a methylglycine derivative. The present invention also relates to a method for depression treatment comprising administrating ketamine combined with a methylglycine derivative. The present invention further provides a method for preventing or treating addictive disorders of ketamine by administrating a methylglycine derivative
抗-乙型淀粉样蛋白抗体及其用途
No full text[[abstract]]一种分离的抗体，其结构包含：轻链CDR1，轻链CDR2，重链CDR1，重链CDR2，以及重链CDR3，所述抗体对Aβ<subgt;1‑42</subgt;或一N端修饰型Aβ<subgt;1‑42</subgt;都具有特异性结合能力。该抗体可用于治疗AD和早期检测脑Aβ含量。N端修饰的焦麸氨酸Aβ(pE‑Aβ3‑42)非常易于聚集，并且对Aβ斑块
[[alternative]]Dipicolylamine derivatives and their pharmaceutical uses
No full text[[abstract]]本發明係提供一種式(I)之二甲基吡啶胺化合物，另提供一種包含金屬離子和這類化合物之醫藥組成物，再提供一種使用這類化合物治療與含磷脂質絲胺酸進出之細胞相關病症之方法
Dipicolylamine derivatives and pharmaceutical use thereof
No full text[[abstract]]FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), where each of A, A, A, A, Aand Ais methylene; Bis ethylene, butylene or hexylene; Bis a bond, ethylene, phenylene,,,,,,,or; Lis a bond, NH, NHCH, NHC(O), NHSO, NHC(O)NH,or; Lis CO; each of W, W, W, W, W, W, Wand Wis CH; or each of W, W, W, and Wis N, and each of W, W, Wand Wis CH; X is a bond, O or NH; Y isor; and Z isor. Invention also relates to specific compounds, a pharmaceutical composition based on compound of formula (I) and Znand a method of treatment.EFFECT: technical result is obtaining a novel heterocyclic compound useful for treating a condition associated with cells containing "turned-out" phosphatidylserine.12 cl, 2 tbl, 51 e
ジピコリルアミン誘導体及びそれらの薬学的使用
No full text[[abstract]]Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compounds
Derivados de dipicolilamina y sus usos farmacéuticos
No full text[[abstract]]Esta invención se basa en un descubrimiento 5 inesperado de que ciertos derivados de dipicolilamina son eficaces en el suministro de un agente terapéutico a un ' sitio de enfermedad objetivo que tiene fosfatidilserina en las superficies externas de las membranas celulares