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[[alternative]]Apparatus for combining imaging ultrasonic probe and focused ultrasonic probe
No full text[[abstract]]本發明是一種將影像超音波探頭與聚焦超音波探頭進行結合的裝置，實現超音波影像導引聚焦超音波治療之技術。其裝置包含：一主體，其內部設置有一接合部可容置一影像超音波探頭，一前端部，其係連接設置於該主體之前端，以及一聚焦超音波探頭，其包含至少一壓電片，係連接設置於該主體及該前端部之間。藉由該技術可即時監控治療位置與效果，並可回饋修正與調整治療的程序或時間等參數，改善治療的品質與效果，可用有限資源提升醫療水準
[[alternative]]Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
No full text[[abstract]]composition comprising a polymer that comprises oxidated hyaluronic acid cross-linked by a dihydrazide is disclosed. The polymer is a hydrogel exhibiting the following properties: a) transparent and colorless; and b) transforming from a liquid state into a gel-matrix at 37° C. These characteristics make it useful as a vitreous humor substitute
Wearable ultrasonic therapeutic device controlled by mobile electronic device
No full text[[abstract]]A wearable ultrasonic therapeutic device controlled by a mobile electronic device is provided, which includes a mobile device, at least one ultrasonic probe module and a strap. The mobile device has a mobile device control interface for setting ultrasonic parameters and displaying an echo wave through a specific software interface of the mobile device. The ultrasonic probe module includes at least one ultrasonic transducer and a control circuit corresponding thereto. The ultrasonic transducer generates and receives an ultrasonic wave. The control circuit has the functions of generating/receiving signals, phase regulation, power amplification and matching. One end of the ultrasonic probe module is electrically connected to the mobile device and the other end of the ultrasonic probe module is connected to the strap
Inverted bowl shaped ultrasound probe structure of guiding the puncture needle
No full text[[abstract]]An ultrasound probe structure dedicated for guiding the puncture needle. It has a passage in the center of the structure and the diameter of the passage is equal to the outer diameter of puncture needle. The bony and non-bony tissues can be distinguished according to the strength of the echoes so that the puncture needle can be guided to avoid hitting the bony tissue before or during insertion
チロシンキナーゼ阻害剤としての融合2環および3環ピリミジン化合物
No full text[[abstract]]Fused bicyclic or tricyclic compounds of formula (I): wherein A, B, C, X, Y, m, and n are defined herein. Also disclosed are a method for inhibiting EGFR kinase activity and a method for treating cancer with these compounds
[[alternative]]Method for calculating activity duration and efficiency
No full text[[abstract]]本發明為一種計算活動期間的方法，包含收集使用者的GPS資料，並將GPS資料作為使用者資料、將使用者資料分為區內點及區外點、將區外點設為活動起點或活動終點、將其中一個活動起／終點設為期間起／終點，令期間起點與期間終點之間的期間時間差為活動期間；一種計算活動效率的方法，包含收集行動裝置的使用資料、依活動期間標籤使用資料、將已標籤之使用資料設為資料集，再以資料集訓練類神經網路，其中類神經網路產生基於使用資料的特徵值，並依特徵值計算活動效率；本發明大幅提升勞工檢查的效率，且幫助無固定排班工作者獲得更好的福利
Dipicolylamine derivatives and their pharmaceutical uses
No full text[[abstract]]Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compound
Dipicolylamine derivatives and their pharmaceutical uses
No full text[[abstract]]Dipicolylamine compounds of Formula (I) set forth herein, that exhibit binding to phosphatidylserine. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, such as cancer, with these compounds
Heterocyclic compounds and use thereof
No full text[[abstract]]Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds
Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's disease
No full text[[abstract]]BackgroundEffective treatment for Alzheimer's disease (AD) remains an unmet need. Thus, identifying patients with mild cognitive impairment (MCI) who are at high-risk of progressing to AD is crucial for early intervention.MethodsBlood-based transcriptomics analyses were performed using a longitudinal study cohort to compare progressive MCI (P-MCI, n = 28), stable MCI (S-MCI, n = 39), and AD patients (n = 49). Statistical DESeq2 analysis and machine learning methods were employed to identify differentially expressed genes (DEGs) and develop prediction models.ResultsWe discovered a remarkable gender-specific difference in DEGs that distinguish P-MCI from S-MCI. Machine learning models achieved high accuracy in distinguishing P-MCI from S-MCI (AUC 0.93), AD from S-MCI (AUC 0.94), and AD from P-MCI (AUC 0.92). An 8-gene signature was identified for distinguishing P-MCI from S-MCI.ConclusionsBlood-based transcriptomic biomarker signatures show great utility in identifying high-risk MCI patients, with mitochondrial processes emerging as a crucial contributor to AD progression