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Dipicolylamine derivatives and their pharmaceutical uses
No full text[[abstract]]Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compounds
Pyrazole derivatives
No full text[[abstract]]FIELD: chemistry.SUBSTANCE: pyrazole derivatives are disclosed, which are encompassed by formula (I), in which radicals and groups are defined in patent claim and which are suitable for treating disorders mediated by peripheral cannabinoid 1 receptor 1.EFFECT: invention also discloses pharmaceutical compositions and methods related to use of said compounds.29 cl, 11 e
Heterocyclic compounds and use thereof
No full text[[abstract]]Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds
Prenatal perfluoroalkyl substance exposure in association with global histone post-translational methylation in 2-year-old children
No full text[[abstract]]Perfluoroalkyl substances (PFASs) have elimination half-lives in years in humans and are persistent in the environment. PFASs can cross the placenta and impact fetal development. Exposure to PFASs may lead to adverse effects through epigenetic mechanisms. This study aimed to investigate whether prenatal exposure to perfluorooctyl sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) was associated with global histone methylation level changes among the 130 2-year-old children followed-up in a birth cohort study in Taiwan. PFOS, PFOA, PFNA, and PFUA were measured by UHPLC/MS/MS in cord blood. Global histone methylation levels were measured from the blood leukocytes of 2-year-old children by Western blotting. Multivariable regression analyses were applied to adjust for potential confounding effects. Among the 2-year-old children, an IQR increase in the natural log-transformed PFUA exposure was associated with an increased H3K4me3 level by 2.76-fold (95%CI = (0.79, 4.73), p = 0.007). PFOA and PFNA exposures was associated with a decreased H3K27me3 level by 2.35-fold (95%CI = (-4.29, -0.41), p = 0.01) and 2.01-fold (95%CI = (-4.00, -0.03), p = 0.04), respectively. Our findings suggest that prenatal PFAS exposure affected histone post-translational modifications
Unveiling the relationship between obesity and social-physical dynamics: An innovative study leveraging smartphone interaction data and actigraphy
No full text[[abstract]]Introduction: This research introduces “social-physical coherence,” a novel metric designed to quantify the congruence between social and physical activities, exploring its link to body fat levels. Method: Engaging 100 subjects—including those with a history of major depression, obesity sufferers, and health professionals in a wellness program—this study employed wrist-worn actigraphy and the Rhythm smartphone app to amass over 3000 days of activity data. The app's analysis of rest-activity rhythms (RAR), including interdaily stability (IS), and actigraphy provided dual RAR insights. Socialphysical coherence was assessed by merging physical activity insights from actigraphy with social engagement data derived from smartphone interactions. Results: Findings highlighted a pronounced positive relationship between social-physical coherence and IS metrics, particularly noting a robust link with the app-derived IS over 1–6 weeks (all ρ > 0.5, p < 0.05). An inverse relationship was observed between socialphysical coherence (and app-based IS) and body mass index in the initial 2–4 weeks, contrasting with the lack of significant findings in actigraphy-based IS measures. Conclusion: The research underscores that greater synchrony in social and physical engagements, or enhanced regularity in social activities, correlates with reduced obesity levels, enriching our understanding of the dynamics between social-physical coherence and body fat
Associations between urinary parabens and thyroid hormone homeostasis across trimesters in Taiwanese pregnant women
No full text[[abstract]]Few studies have explored the link between paraben exposure and thyroid hormone homeostasis in pregnant women across trimesters. The present study involved 97 pregnant women from southern Taiwan (2013-2014), and involved measuring urinary methyl, ethyl, propyl, and butyl parabens, as well as serum thyroid hormones and related indices, such as Structure Parameter Inference Approach-Glandular Disturbance [SPINA-GD], and SPINA Global Turnover [SPINA-GT]). Generalized estimating equations (GEE) were applied to examine the effect of longitudinal paraben exposure on thyroid hormone homeostasis. We found that propylparaben and butylparaben levels were associated with increased FT(4) levels at the second visit (β = 0.07, p = 0.019; β = 0.08, p = 0.002), respectively. The GEE analysis further supported these associations, indicating the positive association between propylparaben levels and both T(3) and FT(4) levels over time (β = 0.05, p = 0.019 and β = 0.05, p = 0.026, respectively). Moreover, butylparaben levels were positively associated with FT(4) (β = 0.05, p = 0.004) and inversely associated with the T(4)/FT(4) ratio and SPINA-GD values (β = -0.04, p = 0.039 and β = -1.63, p = 0.004, respectively). In the GEE and BKMR analyses, a positive association was observed between PrP or paraben mixtures and T(3) and FT(4) levels, respectively. The findings of this study indicate that paraben and paraben mixtures have the potential to disrupt thyroid homeostasis by exerting a diverse hormonal effect. Further research is required to substantiate these conclusions in larger sample size populations
Effects of forest bathing and the influence of exposure levels on cognitive health in the elderly: Evidence from a suburban forest recreation area
No full text[[abstract]]Using nature for cognitive enhancement has great potential. The potential effects of engagement with nature on cognitive aging have been receiving attention, particularly due to the challenges posed by an aging society. Forest bathing involves structured therapeutic recreational activities that could improve cognitive performance within a forest environment. However, the frequency, intensity, and duration of exposure to nature may hold different degrees of importance when it comes to health outcomes. In this study, a within-subjects design experiment was used to evaluate cognitive responses before and after participation among the elderly in a self-guided forest bathing program. Objective exposure metrics, including frequency of visits, walking distance, and time spent in the forest over a week, were employed to investigate subjects’ cognitive enhancement. The results revealed significant improvements in cognitive performance indicators. Through the Stroop test, participants showed reduced completion times in all sections after engaging in the self-guided forest bathing program. The Forward Digit Span Task and the Remote Associates Test scores displayed a significant increase following the self-guided forest bathing, indicating improvements in working memory and creativity, respectively. A negative correlation was observed between the change in time required to complete the Stroop task section involving color identification of neutral words and the frequency of forest bathing practices, suggesting that more frequent forest bathing practices may enhance the attentional control of the elderly. Moreover, a positive correlation was identified between the change in the backward Digit Span Task score and the frequency of self-guided forest bathing practices over a week, suggesting that regular engagement in forest bathing may have a positive impact on enhancing the working memory of the elderly
Prognostic significance of diagnosis-to-surgery interval in oral cavity squamous cell carcinoma: A nationwide study
No full text[[abstract]]Background: The question as to whether prolonged diagnosis-to-surgery intervals (DSIs) may compromise survival outcomes in patients with oral cavity squamous cell carcinoma (OCSCC) remains unanswered. This nationwide study was designed to address this issue. Methods: We analyzed data from 26,214 patients with first primary OCSCC identified in the Taiwanese Cancer Registry Database between 2011 and 2021. The optimal DSI cutoff was determined based on 5-year disease-specific survival (DSS) and overall survival (OS) rates using Cox regression analysis. Patients were categorized into three distinct DSI groups: ≤20 days (47 %), 21–31 days (31 %), and > 31 days (22 %). Results: The 5-year DSS and OS rates for the ≤20/21–31/>31 days groups were 81 %/78 %/77 % and 73 %/70 %/68 %, respectively (both p 31 days (versus ≤ 20 days) retained independent associations with adverse outcomes at 5 years, with hazard ratios of 1.07 for both DSS and OS. Propensity score matching and multivariable analysis comparing DSI ≤ 20 days to DSI > 31 days stratified by pathological stage III–IV showed that higher DSS and OS rates were observed in patients with DSI ≤ 20 days than DSI > 31 days (68 %/66 %, p = 0.0586; 60 %/57 %, p = 0.0228, respectively), with hazard ratios of 1.09 for both DSS and OS. Conclusions: Our findings indicate that DSI is an independent predictor of 5-year DSS and OS in patients with OCSCC. A DSI exceeding 31 days, or even 21 days, may potentially decrease survival outcomes
縮合多環式化合物の調製方法
No full text[[abstract]]To provide a method for preparing a compound of formula (I), particularly a production method therefor on a multi-kilogram scale.SOLUTION: In the formula (I), B represents arylene or heteroarylene, D represents alkyl, alkenyl, alkynyl, aryl, monocyclic heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group, W and Z independently represent hydrogen, alkyl, alkenyl, alkynyl, aryl, monocyclic heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkenyl alkoxy, halogen, an alkoxyamino group, or an alkoxyalkyl amino group, R1 and R2 independently represent hydrogen, halogen or OA. Both of R1 and R2 are not hydrogen. A represents an alkylamino group. n represents 0, 1, 2, 3 or 4. In several preferable embodiments, the compound of formula (I) is recrystallized from a solvent.SELECTED DRAWING: Non
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
No full text[[abstract]]Fused bicyclic pyrimidine compounds of formula (I) defined herein. Also disclosed are amethod for inhibiting Aurora kinase activity and a method for treating cancer with thesecompounds