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Heterodimeric vascular endothelial growth factor and use thereof
No full text[[abstract]]A fusion protein, comprising: (i) a first vascular endothelial growth factor (VEGF) isoform, and (ii) a second VEGF isoform, and (iii) a dimerization domain between th
异质双聚体型血管内皮生长因子及其应用
No full text[[abstract]]本发明关于一种融合蛋白，包含：(i)第一血管内皮生长因子同功异形体，与(ii)第二血管内皮生长因子同功异形体，及(iii)介于该第一同功异形体与该第二同功异形体间的双聚化功能域，其中该第一同功异形体及该第二同功异形体选自VEGF121及VEGF165
[[alternative]]Combined teaching aid for immunology principle
No full text[[abstract]]本实用新型提供一种免疫学原理的组合式教具，用于演示或学习免疫学原理，尤其是抗体的结构以及抗原与抗体专一性结合的机制。该教具可应用于科学普及教育、教师教学、展示、游戏、居家娱乐等各种情境。The utility model provides a combined teaching aid for an immunological principle, which is used for demonstrating or learning the immunological principle, especially the structure of an antibody and the mechanism of specific combination of an antigen and the antibody. The teaching aid can be applied to various situations such as science popularization education, teacher teaching, display, games, home entertainment and the like
Anti-obesity microbiota compositions and preparation methods and uses thereof
No full text[[abstract]]The present invention relates to microbiota compositions and their preparation methods and uses. Particularly, the present invention provides microbiota compositions collected from a dual-specificity phosphatase 6 (dusp6) deficient mammal, which is effective in altering a relative abundance of gut microbiota and also useful in reducing body weight, fat mass, and/or size of adipocytes and increasing oxygen consumption and/or energy expenditure and thus can be used to treat or prevent obesity or its associated disorders or conditions in a subject in need
AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune disease and IL-17A-associated disease
No full text[[abstract]]A method for identifying an AhR-phospho-RORγt protein complex inhibitor, comprising: (a) providing a cell culture, in which cells in the culture express AhR protein and phospho-RORγt protein; (b) incubating the cell culture in the presence of a test agent; (c) assaying the level of the AhR-phospho-RORγt protein complex in the presence of the test agent; (d) comparing the level of the AhR-phospho-RORγt protein complex in the presence of the test agent with a control; and (e) identifying the test agent as the inhibitor of the AhR-phospho-RORγt protein complex when the comparing step indicates that there is a reduction in the level of the AhR-phospho-RORγt protein complex in the presence of the test agent as compared with the control. A method for identifying a GLK−IQGAP1 protein complex inhibitor is also disclosed. Use of identified inhibitors in the manufacture of a medicament for treating a disease is also disclosed
[[alternative]]Ahr-ror-γt complex as a biomarker and therapeutic target for autoimmune disease and il-17a-associated disease
No full text[[abstract]]本發明揭示一種用於識別AhR-磷酸-RORγt蛋白質複合體抑制劑之方法，其包括：(a)提供細胞培養物，其中該培養物中之細胞表現AhR蛋白質及磷酸-RORγt蛋白質；(b)在測試劑之存在下培育該細胞培養物；(c)在測試劑之存在下分析AhR-磷酸-RORγt蛋白質複合體之含量；(d)比較在測試劑之存在下AhR-磷酸-RORγt蛋白質複合體與對照之含量；及(e)當比較步驟指示與對照相比，在測試劑之存在下AhR-磷酸-RORγt蛋白質複合體之含量降低時，即識別該測試劑為AhR-磷酸-RORγt蛋白質複合體之抑制劑。本發明亦揭示一種用於識別GLK-IQGAP1蛋白質複合體抑制劑之方法。本發明亦揭示經識別之抑制劑於製造用於治療疾病之藥劑中的用途
A microfluidic hydrodynamic shuttling chip device for highthroughput multiple single cells capture
No full text[[abstract]]A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a capture site; (b) a large chamber located posterior to the capture site, having a receiving structure spaced apart from the capture site at a distance of g; (c) a trapping channel located between the capture site and the receiving site; (d) a chamber channel located posterior to and in fluidic connection with the large chamber; and (e) a by-pass channel, located lateral to the incoming channel, large chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed
抗癌化学療法剤用のケージ化された白金ナノクラスタ
No full text[[abstract]]A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same
[[alternative]]An ultrasound probe structure
No full text[[abstract]]一種超音波探頭結構係在該探頭結構中心處設有一通道，並且該通道直徑為穿刺針的外徑，當穿刺針經此中心通道進行穿刺時，不管是穿刺前或穿刺中，通道周圍的壓電換能器都可即時接收組織的超音波回波訊號，藉由回波訊號的強弱來辨識出骨組織與非骨組織，用以導引穿刺針來避開骨組織
Radioactive gold nanoparticles and methods of making and using them
No full text[[abstract]]Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed