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Fabrication of multilayer cellulose filters isolated from natural biomass for highly efficient air filtration for replacement of synthetic HEPA filters
No full text[[abstract]]Indoor air pollution can be extensively reduced by using a molecular air filtration system. However, widely utilized synthetic polymer-based filtration medium can lead to waste management difficulty after use. Consequently, this work aimed to synthesize highly efficient air nano-filters derived from renewable and biodegradable resources namely EFB and Pulp. The study successfully presented an air filter from 100 % natural cellulose using a facile physical multilayer filter fabrication method. A combination of chemical and mechanical treatment was applied to prepare nanocellulose. The chemical composition analysis showed that 66–67 % nanocellulose yield was efficiently isolated from both raw materials. The highest particle filtration efficiency (PFE) of 97.30 % (0.3 μm particle size) greater than that of commercial HEPA filters was achieved from multilayer acid-derived microfiber@mechanically treated nanofibers from EFB with low-pressure drop of 11.56 mm H2O. When %PFE and pressure drop were taken into consideration, all single-layer and multilayer-patterned fiber filters in this study provided high quality factor (QF) beyond 0.01 Pa−1 which is the target of the air filter. The findings revealed that the pattern-layer filters through TBA-induced freezing-drying technique could achieve the removal of microbial model and Particulate Matters (PM1.0) represented as 0.1 and 0.3 μm particles, at the very low-pressure drop. Therefore, this study not only enhances the value of natural lignocellulosic wastes but also presents inspiring concepts for creating biodegradable cellulose-based air filters that will pave the way to more eco-friendliness and sustainability for synthetic filter replacement
Perspectives of the medical oncologist regarding adjuvant chemotherapy for pancreatic cancer: An international expert survey and case vignette study
No full text[[abstract]]Introduction: Adjuvant chemotherapy improves survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). The decision to initiate chemotherapy involves both patient and physician factors, decision-specific criteria, and contextual considerations. This study aimed to assess medical oncologists' views on adjuvant chemotherapy following pancreatic resection for PDAC. Methods: An online survey and case vignette study were distributed to medical oncologists via the Dutch Pancreatic Cancer Group (DPCG), International Hepato-Pancreato-Biliary Association (IHPBA) and related networks. Results: A total of 91 oncologists from 14 countries participated, 46 % of whom treated more than 40 new PDAC patients annually, with a median experience of 15 years. Significant discrepancies were noted in their recommendations for adjuvant chemotherapy across case vignettes. In patients over 70, 17 % advised against chemotherapy, while 31 % said age was not a factor. Oncologists with less than 10 years of experience and those in non-academic settings were less likely to recommend adjuvant therapy. While 87 % agreed mFOLFIRINOX is the preferred adjuvant treatment, consensus on individual cases was lacking. The recommended interval between surgery and chemotherapy ranged from 3 to 26 weeks, with varying reasons for withholding treatment, primarily due to postoperative recovery and performance status. Conclusions: Our study revealed substantial variation among oncologists in counseling on adjuvant chemotherapy after PDAC resection. This emphasizes the need for more patient involvement in decision-making and improving shared decision-making
Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
No full text[[abstract]]Introduction: The relations between coffee and tea consumption and head and neck cancer (HNC) incidence are unclear. With increasing global HNC burden, this study aims to examine the association between coffee, tea, and HNC. Methods: A pooled analysis of 9548 HNC cases and 15,783 controls from 14 individual-level case-control studies was conducted from the International Head and Neck Cancer Epidemiology consortium. Random-effects logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for HNC and its subsites, adjusting for sociodemographic and lifestyle factors. Results: Compared to non–coffee drinkers, drinking >4 cups of caffeinated coffee daily was inversely associated with HNC (OR, 0.83; 95% CI, 0.69–1.00), oral cavity (OR, 0.70; 95% CI, 0.55–0.89), and oropharyngeal cancers (OR, 0.78; 95% CI, 0.61-0.99). Drinking 3–4 cups of caffeinated coffee was inversely associated with hypopharyngeal cancer (OR, 0.59; 95% CI, 0.39–0.91). Drinking decaffeinated coffee and drinking between >0 to 0 to ≤1 cup was inversely associated with HNC (OR, 0.91; 95% CI, 0.84–0.98) and hypopharyngeal cancer (OR, 0.73; 95% CI, 0.59–0.91), but drinking >1 cup was associated with laryngeal cancer (OR, 1.38; 95% CI, 1.09–1.74). Conclusion: These findings support reduced HNC risk among coffee and tea drinkers. Future studies are needed to address geographical differences in types of coffee and tea to improve our understanding of the association of coffee and tea and global HNC risk
Aminothiazole compounds as protein kinase inhibitors
No full text[[abstract]]Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds
[[alternative]]MAP4k3 as a biomarker and therapeutic target for autoimmune disease cancer inflammation and il-17-associated disease
No full text[[abstract]]배아 중심 키나제(GCK)-유사 키나제(GLK)-매개된 질병을 치료하기 위한 치료제를 확인하는 방법이 개시되어 있다. 시험 화합물에 의한 GLK 시그널링의 조절을 검출하는 방법이 개시되어 있다. 자가면역 질병 및/또는 암의 존재 및/또는 심각성을 검출하는 방법이 또한 개시되어 있다
人工淚液組合物
No full text[[abstract]]一種治療乾眼症之人工淚液組合物，其主要係由一具有抗發炎及抗氧化物質、一可增加液體黏稠度的物質以及一人工淚液所組合而成，該人工淚液組合物不僅具保濕功效，且同時具有抗發炎及抗氧化功能，亦可延長該人工淚液組合物滯留眼表時間，以減少重複點眼藥水之動作及有效縮短治療乾眼症之療程
细胞内药物释放的组合物及方法
No full text[[abstract]]本发明提供细胞内药物释放的组合物及方法。该方法包括：(a)提供一组合物，其包括一治疗有效量的药剂，该药剂吸附于具有疏水性表面的中孔径羟基磷灰石(HAP)上；(b)将该组合物暴露至一细胞；(c)使该中孔径羟基磷灰石进入该细胞中并于该细胞的溶酶体中降解，而使该药剂自该中孔径羟基磷灰石脱附；(d)使该经脱附的药剂由该溶酶体释出至该细胞的细胞质中；以及(e)使该经脱附的药剂释出至细胞外。该组合物包括(a)具疏水性表面的中孔径羟基磷灰石(HAP)；(b)一治疗有效量的药剂，其吸附于该中孔径羟基磷灰石的疏水性表面上
用于高通量多数单细胞捕获之微流体动力式转运晶片
No full text[[abstract]]本发明揭露一种微流体动力式转运晶片包含一单细胞捕捉单元阵列。每一单元包含：(a)一入口通道具有一捕捉处；(b)一大容室位于捕捉处的后方且具有一接收处其与捕捉处相距一距离g；(c)一局限通道位于捕捉处以及接收处之间；(d)一容室通道可流通地位于大容室后方；以及(e)一回避通道并列于入口通道、大容室以及容室通道且具有一第一端及一第二端相对第一端，其中第一端由邻近捕捉处前方的入口通道分支出，而第二端则接合于容室通道。本发明亦揭露捕捉多于一种单细胞的方法。A hydrodynamic shuttling chi
磁振造影系统
No full text[[abstract]]本发明公开了一种用在受测者目标区域的医疗期间使用的磁振造影系统，包括用以将能量传送给受测者的治疗装置；用于缠绕受测者躯干以接收来自受测者的RF讯号的可挠RF线圈带，该可挠RF线圈带包括第一RF线圈、第二RF线圈、第三RF线圈和第四RF线圈，该可挠RF线圈带的每一个线圈接收的RF讯号能够连接到个别的前置放大器，以同时取得多通道的讯号；该磁振造影系统还包括一图像处理装置用于处理从可挠RF线圈带取得的多通道RF讯号，再以平行MRI技术形成一磁振造影影像
Multiple-frequency ultrasonic phased array driving system
No full text[[abstract]]An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies