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Lernen und Leben im Trialog:eine qualitativ-empirische Untersuchung zur Rekonstruktion religiöser Kompetenzen von Grundschülerinnen und -schülern an der Drei-Religionen-Schule Osnabrück
No full textDie „Drei-Religionen-Schule, Johannisgrundschule“ in Osnabrück stellt deutschlandweit ein einmaliges Schulprojekt dar. In Kooperation mit Juden und Muslimen sollen praxistaugliche Antworten gegeben werden, wie an einer Katholischen Schule, unter dem Gesichtspunkt einer religiös und kulturell pluralen Schülerschaft, eine auch interreligiöse Identitätsbildung gelingen und gleichzeitig dem Auftrag zur Evangelisierung beizutragen, nachgekommen werden kann. Diese Schule stellt ein Praxisfeld dar, in dem die Wirksamkeit des Religionsunterrichts aus der Binnenperspektive in inhaltlicher Verantwortung der jeweiligen Religionsgemeinschaft mit Blick auf die verschiedenen Lernzielbereiche untersucht, analysiert und reflektiert werden kann. Die vorliegende Forschungsarbeit liefert eine wissenschaftliche Dokumentation und Reflexion. Es handelt sich um eine qualitative Evaluationsstudie zur religiösen Kompetenzentwicklung von Schülerinnen und Schülern
LGBTIQ+ inclusive curriculum in Higher Education:Issues and Challenges
No full textThis book is an attempt to provide an overview of the situation of LGBTIQ+ studies on all continents. Few universities offer LGBTIQ+ studies, modules, or courses. Most queer studies are conducted under the umbrella of the Gender Studies department, while LGBTIQ+ studies are marginalized in higher education and the community still suffers from exclusion and discrimination. This book, which gathers voices from around the world, is merely a first step towards a world that will hopefully be characterized by diversity, understanding and respect
Literaturtheorien und Zukunft:Bestandsaufnahme – Aktualisierungen – Tendenzen
No full textDer Beitrag skizziert ausgehend von einem merklichen Aufschwung neuerer Anthropozentrismus-kritischer Theorieansätze damit einhergehende Anschlussfragen, die einen eventuellen Modifikationsbedarf zugrunde liegender Prämissen, Möglichkeiten funktionaler Ausdifferenzierung und Klassifikation sowie das Verhältnis zu ›etablierten‹ Literaturtheorien in den Blick nehmen
Long-Term Outcomes of Canaliculotomy with Silicone Tube Intubation in the Management of Canaliculitis
No full textAs a rare and often misdiagnosed disease of the lacrimal apparatus, only limited data exist on long-term outcomes of surgical methods for the treatment of primary canaliculitis. The aim of this study was to evaluate canaliculotomy with silicone tube intubation (STI) as a surgical procedure for canaliculitis in a long-term follow-up setting. A total of 25 eyes of 25 patients with canaliculitis treated with canaliculotomy and STI at the University of Muenster Medical Center, Germany, from 2015 to 2021 were included in this study. Data analysis involved clinical symptoms, complications, duration of STI and rate of recurrence. Mean patient age was 63.7 ± 17.2 years. After a follow-up time of 3.7 ± 1.5 years, 88% of cases showed no recurrence of inflammation. The mean duration of STI was 5.8 ± 3.4 months. Complications such as post-operative hemorrhage, spread of infection, obstruction of the canaliculus or migration of the STI were not observed in any of the patients. However, tube dislocation occurred in four cases, a pyogenic granuloma in two cases and a fistula formation in one case. The management of canaliculitis by canaliculotomy with STI showed very good postoperative outcomes and low complication rates in the long-term and can therefore be considered a safe and successful surgical approach
Mergers & Acquisitions (M&A) in the Pharmaceutical and Chemical Industries: A Lighthouse in Choppy Waters
No full textPhosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK
No full textThe master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK. Activation of AMPK by low energy supply and phosphorylation of LKB1 results in an inhibition of mTOR, thus decreasing energy-consuming processes, in particular translation and, thus, cell growth. LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. Here, we report that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. In Drosophila, knockin of phosphorylation-deficient LKB1 results in normal survival of the flies, but an increased activation of LKB1, whereas a phospho-mimetic LKB1 variant displays decreased AMPK activation. As a functional consequence, cell growth as well as organism size is decreased in phosphorylation-deficient LKB1. Molecular dynamics simulations of PDK1-mediated LKB1 phosphorylation revealed changes in the ATP binding pocket, suggesting a conformational change upon phosphorylation, which in turn can alter LKB1's kinase activity. Thus, phosphorylation of LKB1 by PDK1 results in an inhibition of LKB1, decreased activation of AMPK and enhanced cell growth
PHOTONAI—A Python API for rapid machine learning model development
No full textPHOTONAI is a high-level Python API designed to simplify and accelerate machine learning model development. It functions as a unifying framework allowing the user to easily access and combine algorithms from different toolboxes into custom algorithm sequences. It is especially designed to support the iterative model development process and automates the repetitive training, hyperparameter optimization and evaluation tasks. Importantly, the workflow ensures unbiased performance estimates while still allowing the user to fully customize the machine learning analysis. PHOTONAI extends existing solutions with a novel pipeline implementation supporting more complex data streams, feature combinations, and algorithm selection. Metrics and results can be conveniently visualized using the PHOTONAI Explorer and predictive models are shareable in a standardized format for further external validation or application. A growing add-on ecosystem allows researchers to offer data modality specific algorithms to the community and enhance machine learning in the areas of the life sciences. Its practical utility is demonstrated on an exemplary medical machine learning problem, achieving a state-of-the-art solution in few lines of code. Source code is publicly available on Github, while examples and documentation can be found at www.photon-ai.com
Promising Mid-Term Outcomes after Humeral Head Preserving Surgery of Posterior Fracture Dislocations of the Proximal Humerus
No full textBackground: The aim of this study was to evaluate the clinical outcome after humeral head preserving surgical treatment of posterior fracture dislocations of the proximal humerus. Methods: Patients with a posterior fracture dislocation of the proximal humerus that were operatively treated in two level-1 trauma centers within a timeframe of 8 years were identified. With a minimum follow-up of 2 years, patients with humeral head preserving surgical treatment were invited for examination. Results: 19/24 fractures (79.2%; mean age 43 years) were examined with a mean follow-up of 4.1 ± 2.1 years. Of these, 12 fractures were categorized as posteriorly dislocated impression type fractures, and 7 fractures as posteriorly dislocated surgical neck fractures. Most impression type fractures were treated by open reduction, allo- or autograft impaction and screw fixation (n = 11), while most surgical neck fractures were treated with locked plating (n = 6). Patients with impression type fractures showed significantly better ASES scores (p = 0.041), Simple Shoulder Test scores (p = 0.003), Rowe scores (p = 0.013) and WOSI scores (p = 0.023), when compared to posteriorly dislocated surgical neck fractures. Range of motion was good to excellent for both groups with no significant difference. Conclusions: This mid-term follow-up study reports good to very good clinical results for humeral head preserving treatment
Protoporphyrin IX (PpIX) Fluorescence during Meningioma Surgery: Correlations with Histological Findings and Expression of Heme Pathway Molecules
No full textBackground: The usefulness of 5-ALA-mediated fluorescence-guided resection (FGR) in meningiomas is controversial, and information on the molecular background of fluorescence is sparse. Methods: Specimens obtained during 44 FGRs of intracranial meningiomas were analyzed for the presence of tumor tissue and fluorescence. Protein/mRNA expression of key transmembrane transporters/enzymes involved in PpIX metabolism (ABCB6, ABCG2, FECH, CPOX) were investigated using immunohistochemistry/qPCR. Results: Intraoperative fluorescence was observed in 70 of 111 specimens (63%). No correlation was found between fluorescence and the WHO grade (p = 0.403). FGR enabled the identification of neoplastic tissue (sensitivity 84%, specificity 67%, positive and negative predictive value of 86% and 63%, respectively, AUC: 0.75, p < 0.001), and was improved in subgroup analyses excluding dura specimens (86%, 88%, 96%, 63% and 0.87, respectively; p < 0.001). No correlation was found between cortical fluorescence and tumor invasion (p = 0.351). Protein expression of ABCB6, ABCG2, FECH and CPOX was found in meningioma tissue and was correlated with fluorescence (p < 0.05, each), whereas this was not confirmed for mRNA expression. Aberrant expression was observed in the CNS. Conclusion: FGR enables the intraoperative identification of meningioma tissue with limitations concerning dura invasion and due to ectopic expression in the CNS. ABCB6, ABCG2, FECH and CPOX are expressed in meningioma tissue and are related to fluorescence
Provenance:Approaches to a Transatlantic Material History of Literature
No full textDas Unterfangen transatlantischer Forschung stellt gängige Vorstellungen von Archiven in Frage. Caroline Jessen erkennt Tim Sommers Konzeptualisierung von Archiven in Bezug auf Materialität, Logistik und Ökonomie sowie Tobias Boes’ Verständnis von Archiven als Operationen in Abhängigkeit von Raum und Zeit an und plädiert für eine transatlantische Materialgeschichte der Literatur. Sie schlägt vor, Provenienz als epistemische Kategorie wahrzunehmen und, der Spur der Provenienzinformationen folgend, den Bestand, den die Kataloge der Archive sichtbar machen, durch die Berücksichtigung transatlantischer Transfers, früherer Eigentumsverhältnisse, Gebrauchs- und Bedeutungszusammenhänge zu hinterfragen.The endeavor of transatlantic research challenges common ideas of archives. Acknowledging Tim Sommer's conceptualizing archives in terms of materiality, logistics, and economy as well as Tobias Boes' thinking of archives as spatio-temporal operations, Caroline Jessen proposes a plea for a transatlantic material history of literature. Focusing on provenance as an epistemic category, Jessen suggests to use provenance as an epistemic category and to interrogate archival holdings as presented in catalogs and databases, by paying attention to transatlantic transfers, past ownership, and contexts of use and meaning which are marked by provenance information