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Evaluating the applicability of ESGO quality indicators in the surgical management of endometrial cancer: Insights from a Francogyn cohort
No full textInternational audienceBackground: Endometrial cancer (EC) is a significant health concern in France, necessitating high-quality surgical care to improve patient outcomes. The European Society of Gynaecological Oncology (ESGO) established quality indicators (QIs) to standardize and improve management.Objective: This study evaluates the applicability of ESGO QIs in a real-world setting across 13 centers in France.Methods: This retrospective multicenter cohort study included 2789 patients surgically treated for EC from 2001 to 2020. Demographic data, surgical techniques, adherence to ESGO QIs and trends over time were analyzed. Key indicators analyzed included multidisciplinary team discussions, pre-operative imaging adequacy, surgical techniques employed, and molecular classifications.Results: All patients were discussed in multidisciplinary meetings. Adequate preoperative imaging was achieved in 80.63 % of cases. Minimally invasive surgery was performed in 66.12 % of early-stage patients, showing a significant year-on-year increase from 12 % in 2001 to 85 % in 2020. Among obese patients, 60.78 % underwent laparoscopic procedures, with a conversion rate to open surgery of 3.57 %. Molecular classification results highlighted 35 % of patients as low risk and 32 % as high risk.Conclusion: Our findings indicate that adherence to actual ESGO QIs has substantially improved the quality of surgical management for endometrial cancer in France, despite some areas requiring further enhancement. A coordinated political approach is essential to address existing barriers and ensure consistent implementation of these quality standards across all centers, ultimately aiming to elevate patient care and outcomes in the French healthcare system
Biography of a Levantine dolmen during the Early Bronze Age: construction, reuse and memory at Rjile (Kufr Yuba, North Jordan)
No full textInternational audienceThe architectural and ritual biography of dolmen ST_30 in the Rjile necropolis (Kufr Yuba, Jordan) provides new chronological and cultural insights into Levantine megalithism. A multidisciplinary investigation – combining building techniques with chaîne opératoire analysis, excavation data, human osteological evidence and scientific dating – reveals at least four distinct phases of use. Optically stimulated luminescence (OSL) dating of sediments indicates that the dolmen was initially constructed and used during the Early Bronze Age (EBA) IB/II and III-IV periods, while a series of calibrated radiocarbon determinations from human remains points to three subsequent episodes of reuse between 3100 BCE and 800 BCE. The limited but significant human assemblage, associated artefacts, and architectural modifications suggest that ST_30 functioned either as a continuous memorial space or, more plausibly, as a funerary monument periodically reactivated over more than a millennium. These results refine the chronological framework for dolmen construction and use in the western Irbid region and highlight the complexity of their cultural biographies
Mechanized Dominator Tree Certification
No full textInternational audienceIn modern compilers, many optimizations and analyses, in particular those based on the SSA form, rely on dominance information, so computing dominators efficiently is an important problem. The classic algorithm to compute dominators in a control flow graph is the one designed by Lengauer and Tarjan in 1979. Other efficient algorithms have been proposed since. Previous works formally verified less efficient algorithms, and formally validated parts of the Lengauer-Tarjan algorithm, but there is no complete formal verification or validation of any of the fast algorithms computing dominators so far. In 2016, Georgiadis and Tarjan described a method to tackle these. They defined a certificate with which it becomes easy to validate dominators. Following their method, we successfully implemented and proved correct a validator of dominators in the Rocq Prover, inside the CompCertSSA verified compiler. This is the first complete mechanized certification of a fast algorithm computing dominators
Functional traits shape tree growth response to winter freeze-thaw cycle and neighborhood crowding in humid temperate forests
No full textInternational audienceClimate change is intensifying the occurrence of hydric events, such as summer water availability and winter freeze-thaw cycles, which are increasingly significant in temperate regions. These events pose substantial threats to tree hydraulic functions and thereby limiting tree growth. In this study, we investigated the compound effects of climate-induced stressors and neighborhood crowding on tree growth, and tested how species functional traits mediate these responses. We combined annual growth data over 8 years from 593 individuals representing 20 tree species in Northeast China to evaluate the relative influence of water availability, freeze-thaw cycles, and their interaction with local crowding on tree growth, and how species functional traits mediate these responses. Our findings indicate that tree growth declined with increasing freeze-thaw cycles frequency, whereas summer water availability had no detectable effect. Tree growth was limited by neighborhood crowding, which appeared to operate largely independently of freeze-thaw cycles. In addition, species with higher xylem hydraulic efficiency, lower wood density and lower specific leaf area grew faster and were more sensitive to freeze-thaw cycles, while species with higher xylem hydraulic efficiency were less sensitive to neighborhood crowding. Our results demonstrate distinct and independent roles of freeze-thaw cycles and neighborhood crowding in shaping temperate tree growth, suggesting that considering the freeze-thaw cycles may improve predictions of temperate forest dynamics facing altered climate changes. Furthermore, species traits can capture how temperate trees cope with different stressors, highlighting the importance of integrating functional traits for a more comprehensive understanding of tree responses to environmental stressors
Assessing the persistence of semi-natural species-rich grasslands under changes in grazing practices: Insights for grassland restoration
No full textInternational audienceGrazing practices are well-known to shape plant populations and communities in semi-natural grasslands and the conservation and restoration of these ecosystems relies heavily on maintaining traditional extensive grazing systems, which have persisted for centuries or even millennia. However the changes of grazing practices in relation to climate change and socio-economic factors can result in biodiversity loss, shifts in vegetation composition, soil degradation, and declines in ecosystem services and habitat quality. This study aimed to understand the medium-term (3-16 years) effects of changes in grazing practices by comparing two sheep grazing methods in semi-natural rangelands of Southern France: millennia-old traditional herding with shepherds and herding dogs, and the recent practice of fenced free grazing, which emerged at the beginning of the 21st century. Surveys were conducted at six paired study sites over three years, assessing vegetation, mesological data, and plant traits. While the five vegetation zones created by traditional herding remain identifiable, the transition to fenced grazing has induced, for the first time in these grasslands, a mid-term homogenization of plant communities, marked by the spread of xero-mesophilous species and the disappearance of the historical grazingintensity gradient. These findings highlight the ecological implications of altered grazing regimes, such as fenced grazing, for biodiversity conservation of rangelands with millennia-long grazing history, ecosystem functionality, and long-term persistence of high heritage value grasslands. They provide critical insights into designing adaptive and sustainable restoration strategies for degraded grasslands under changing environmental and socio-economic conditions
From local wood charcoal to high-performance supercapacitors: The role of pore accessibility
No full textInternational audienceLocally produced wood charcoal was explored as a sustainable and competitive precursor for activated carbon (ACs) applied to advanced energy storage applications. Three different activation strategies were applied: steam activation, KOH activation after physical mixing (KOH-p), and KOH activation after impregnation (KOH-imp). All materials demonstrated good electrochemical performance at low charging rates, achieving specific cell capacitance above 40 F g -1 at 0.5 A g -1 in acidic aqueous electrolyte with the best-performing material demonstrating a remarkable cell capacitance value of 64 F g -1 at 0.5 A g -1 (i.e., a specific electrode capacitance of 257 F g -1 ) while retaining 85 % and 73 % of its performance at 5 and 40 A g -1 , respectively. Moreover, despite comparable BET areas (~1500 m 2 g -1 ) and microporous volumes (~0.5 cm 3 g -1 ), ACs produced by KOH-p exhibited restricted micropore accessibility, leading to lower performance at high charging rates. In contrast, ACs with increased pore volume and wider pore size from the AC-KOH-p series retained 73 % of their capacitance, while the KOH-imp series stabilized at 55 %. These findings highlight the critical role of hierarchical porosity and effective micropore accessibility in enhancing charge transport and overall electrochemical performance, reinforcing the value of local biomass sources in the development of sustainable energy storage materials.</div
Triterpenoids from Astragalus armatus subsp. numidicus and their chemotaxonomic significance
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Sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition
No full textInternational audienceHeparan sulfate (HS) analogs are synthetic oligo- and polysaccharides designed to mimic or enhance several biological properties of native HS. Organic synthesized compounds are very useful tools for understanding the structure-activity relationships of many biological events. Unlike heterogeneous mixtures of tissue-isolated biomolecules, synthetic compounds offer a valuable platform to probe structure-activity relationships with reduced off-target effects in pharmacological applications. In our research group, we are particularly focused on the design and synthesis of thiodisaccharide analogs mimicking HS structural motifs. In recently published work, we reported the synthesis and biological evaluation of both new sulfated and non-sulfated O- and S-linked disaccharides, demonstrating their potential as heparanase inhibitors. In this article, we introduced a sulfonate moiety as a stable analog of the sulfate group. Comparative heparanase inhibition assays reveal that sulfated disaccharides exhibit significantly greater activity than their sulfonated counterparts. Furthermore, multivalent glycoclusters were prepared by coupling sulfated thiodisaccharides to maltotriose and cyclodextrin scaffolds, providing novel molecular architectures that show promising heparanase inhibition
Synchrotron-based infrared microspectroscopy study on the biomolecular impact of carbon minibeam radiation therapy on a mouse osteosarcoma cell line
No full textInternational audienceCarbon minibeam radiation therapy (CMBRT) is a novel oncology treatment modality that combines the superior radiobiological properties of carbon ions with the remarkable tissue-sparing effects of spatial dose fractionation. Nevertheless, the differential biological mechanisms that CMBRT activates are not fully understood. To shed further light on such biomolecular processes, this study analysed the impact of CMBRT on LM8 osteosarcoma cells using synchrotron-based infrared microspectroscopy (SR-FTIRM). Samples were subjected to conventional carbon RT (CBB) and CMBRT at GSI (Germany). RT-treated cells underwent SR-FTIRM evaluations at ALBA Synchrotron (Spain) at 24 h post-RT. Principal component analysis (PCA) uncovered the main spectral differences between the treatment modalities, revealing that the IR signatures of CMBRT-treated samples were the most dissimilar from Control cells. Modifications of IR peaks attributed to -helical and -sheet protein sub-structures were consistent with the alterations of the Amide I spectral band due to CMBRT (assessed via curve-fitting analysis), suggesting enhanced protein oxidation. Conformational alterations in the sugar-phosphate backbone of nucleic acids might also have resulted from further oxidative damage due to CMBRT. Additionally, CMBRT led to greater alterations of methylene and methyl bands compared to CBB, which may have been caused by free radical attacks. Spectral signatures in the CMBRT valleys differed from those in the CMBRT peaks, suggesting distinct biomolecular mechanisms involved in these two dose regions. Comparison with proton and neon irradiations revealed common IR features affected by MBRT modalities