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Metabolomic profiling of urinary phenolic compounds in postmenopausal women after consumption of dark chocolate, green tea, and fruit juice
No full textPostmenopausal women are approximately twice as likely to develop cardiometabolic diseases (CMDs) as premenopausal women. Plant-based diets rich in fruits and vegetables, due to their high content of bioactive compounds such as (poly)phenols, represent a promising strategy to reduce the risk of CMDs in
this population. However, the cardioprotective effects of (poly)phenols depend largely on inter-individual
variability, which is strongly influenced by the gut microbiota composition. Menopause is often associated
with gut dysbiosis, characterized by a reduced microbial diversity and a lower abundance of beneficial
bacteria. This imbalance in the gut microbiota profile of postmenopausal women could influence (poly)
phenol metabolism and, consequently, the health benefits attributed to (poly)phenol-rich food (PP-rich
food) consumption. Therefore, this study aimed to assess the impact of a daily consumption of PP-rich
foods (dark chocolate, green tea and fruit juice) for 2 months on the urinary phenolic profile in postmenopausal
women at high cardiometabolic risk. To this end, 116 urinary phenolic metabolites were determined
using UHPLC-ESI-QqQ-MS/MS. Dietary intervention with PP-rich foods led to a significant
increase in the urinary excretion of phenolic metabolites derived from gut microbiota activity and phase II
metabolism. Notably, there was a significant increase in the excretion of glucuronidated and/or sulfated
conjugates of phenyl-γ-valerolactones, phenylvaleric acids, phenylacetic acids, benzoic acids, and urolithins.
It is expected that these phenolic metabolites could be the bioactive compounds responsible for
the potential beneficial effects derived from the daily intake of dark chocolate, green tea, and fruit juice
on the reduction of the risk of CMDs in postmenopausal women
Compiler-Assisted Instruction Fusion
No full textHardware instruction fusion combines multiple architectural instructions into a single operation, improving performance by freeing up resources. While fusion typically involves consecutive instructions, there are proposals to fuse nonconsecutive instructions to maximize potential. However, such approaches require complex and costly hardware to predict and either validate fusion or unfuse, which significantly increases the cost of fusion. In this work, we propose a compiler technique, CAIF - Compiler Assisted Instruction Fusion, for fusionaware instruction scheduling. CAIF identifies fusible but nonconsecutive memory operations and reorders eligible pairs of instructions such that they appear consecutively in the instruction stream.
Our experiments demonstrate that for neural network workloads, a hardware that only fuses consecutive instructions obtains 1.2% average performance improvements over a no-fusion baseline when applications are compiled with a standard compiler and 19.6% when compiled with CAIF. In addition, when nonconsecutive hardware fusion (Helios) is enabled, CAIF boosts performance from 6.6% to 20.3%. Moreover, CAIF can effectively handle the statically challenging general-purpose application and boost performance on SPEC CPU 2017 from 2.4% to 6.4%, and from 14.4% to 17.7%, respectively, on the hardware configurations mentioned above
Questionario sull’esperienza professionale e sulle pratiche didattiche: il punto di vista degli insegnanti nella scuola secondaria (Q-EPPI)
No full textL'obiettivo di questo strumento è comprendere le condizioni che possano sostenere ambienti di apprendimento inclusivi, efficaci e di successo, a partire dal benessere degli insegnanti. Lo studio ha finalità esclusivamente conoscitive e di ricerca ed è rivolto ai docenti della scuola secondaria di primo e secondo grado, indipendentemente dal ruolo ricoperto (posto comune o sostegno), dal tipo di incarico (di ruolo o supplente) e dalla disciplina insegnata. Curso 2025/202
Messianism and radicalized Modernity. The fiduciary social bond through Derrida’s messianicity
No full textEste artículo propone una articulación entre la noción de lo mesiánico en la filosofía de Jacques Derrida y ciertos rasgos sociales propios de la Modernidad. Defiendo que el concepto de fe en Derrida es indesligable de las propiedades fiduciarias del vínculo social, propiedades que se radicalizan en la modernidad tardía. Apoyándonos en algunos aportes sociológicos, sostendremos que la fe derrideana es una hipérbole de lo que se pone de manifiesto en el socius presente, y que la modernidad socava su horizonte normativo en la forma de una mesianicidad sin mesianismo.This paper attempts to suggest a link between Jacques Derrida’s concept of messian-ism and certain characteristics of Modernity. We uphold that Derrida’s concept of faith is strongly attached to the fiduciary properties of the social bonds, which have been radicalized in the late Modernity. On the basis of some sociological contributions, we sustain that Derridean faith is a hyperbole of what the socius is currently bringing to light, and that Modernity undermines its normative horizon as a messianicity without messianism
A redefinition of prognosis: Invasive carcinoma with metastasis originating from microglandular adenosis
No full textAim. To investigate the clinicopathological features, immunophenotype, diagnosis, and prognosis of invasive carcinoma originating from microglandular adenosis.
Methods. Two cases of invasive carcinoma originating from microadenosis were analyzed in the Department of Pathology of the Ruijin Hospital affiliated with the Medical College of Shanghai Jiaotong University. Histopathological morphology, immuno-histochemical staining, and prognosis were observed.
Results. (1) Histopathological morphology: microscopically, the tumor showed small clusters and nests of infiltrative growth; a few areas showed tubules, and some eosinophilic secretions were observed in the lumen. (2) Immunohistochemistry and molecular genetics: Case 1 was partly positive for S-100, positive for SOX-10, and negative for ER, PR, and HER2 (2+). The result of HER2 gene amplification was negative. Breast and liver tissue lesions in Case 2 were positive for S-100 and SOX-10 but negative for ER and HER2. PR was positive in the liver lesions but showed moderate to strong expression in approximately 80% of the staining. Myoepithelial markers (p63 and calponin) showed loss of myoepithelium around the nests of invasive cancers. TP53 (R213Ter) showed somatic gene variations, and no exon amplification or deletion was detected in BRCA1/2.
Conclusion. Invasive carcinoma originating from microadenosis has the same immunophenotype as microadenosis, and its prognosis is difficult to determine
Education in Democratic Values: The Usefulness of a Training Program on Transparency and Citizen Participation in Secondary Education
No full textIn recent years, educational programs fo
cusing on democratic values, transparency,
access to information, and citizen partici
pation have been implemented in schools.
However, there is a lack of research exa
mining the impact of these initiatives on students. Therefore, the aim of this study
is to assess the impact of a training pro
gram on transparency and open govern
ment among secondary school students.
To achieve this objective, a quantitative
research approach was employed, using
a non-experimental survey design. The
sample consisted of 152 secondary school
students from two schools in the Region of
Murcia. The results indicate a high level
of satisfaction with the training received
and highlight the perceived importance
of knowledge related to transparency and
open government. In conclusion, the fin
dings emphasize the relevance of incor
porating this type of training in schools
to promote socio-educational programs
that strengthen democratic values among
young people.Ces dernières années, des programmes ont été mis en place pour mettre l’accent sur les
valeurs démocratiques, la transparence, l’accès à l’information et la participation cito
yenne dans les établissements scolaires. Cependant, il n’existe pas beaucoup de travaux
qui approfondissent l’impact de ces formations éducatives sur les étudiants. C’est pour
quoi l’objectif de ce travail est de connaître l’impact d’un programme de formation sur
la transparence et le gouvernement ouvert chez les élèves de l’enseignement secondaire.
Pour répondre à cet objectif, une méthode de recherche quantitative a été utilisée, en
particulier un design non expérimental de type enquête auquel ont participé 152 élèves
de secondaire issus de deux établissements scolaires de la région de Murcie. Les résul
tats montrent un niveau élevé de satisfaction concernant la formation reçue, en plus de
valoriser les connaissances sur la transparence et le gouvernement ouvert. En conclusion,
l’importance de ce type de formation dans les établissements scolaires est mise en avant
afin de continuer à soutenir des programmes socio-éducatifs qui renforcent les valeurs
démocratiques chez les jeunes.En los últimos años se han llevado a cabo
programas que ponen el foco sobre los
valores democráticos, la transparencia, el
acceso a la información y la participación
ciudadana en los centros educativos. Sin
embargo, no abundan los trabajos que profundizan sobre el impacto que tienen
dichas formaciones educativas en los estu
diantes. Por ello, el objetivo del presente
trabajo es conocer el impacto que tiene
un programa de formación sobre transpa
rencia y gobierno abierto en estudiantes
de Educación Secundaria. Para dar res
puesta a este objetivo se utilizó un método
de investigación cuantitativo, en concreto
un diseño no experimental tipo encuesta
en el que participaron 152 estudiantes de
Secundaria pertenecientes a dos centros
educativos de la Región de Murcia. Los
resultados muestran un elevado nivel de
satisfacción sobre la formación recibida,
además de poner en valor los conocimien
tos sobre transparencia y gobierno abierto.
En conclusión, se pone de relieve la im
portancia de este tipo de formaciones en
los centros educativos con el fin de seguir
apostando por programas socioeducativos
que incrementen los valores democráticos
en la juventud
Effervescence and feminisms in the 1990S. The irruption of postidentitarian theories in the feminist art scene in Spain
No full textEsta investigación recorre las genealogías feministas en el arte contemporáneo del Estado español y cómo la práctica artística de las mujeres artistas de los años noventa se contagia de las teorías postidentitarias o queer. La irrupción de los discursos de la disidencia de género llega en una época en la que el panorama artístico feminista todavía trataba de solidificarse después de verse opacado por cuarenta años de dictadura. A su vez, indaga en las políticas culturales del territorio español y el punto de inflexión que supuso la crisis de legitimidad en el sistema socioeconómico que imperaba en la España democrática después de la Transición. Por último, analiza los componentes que precipitaron finalmente el estallido de unos años noventa políticos, en los que la militancia feminista en las artes visuales contemporáneas, en su trasvase con lo queer y otros movimientos sociales, sería decisiva en la reconfiguración de la escena artística al margen de los discursos institucionales.This research traces the feminist genealogies in contemporary art in Spain and how the artistic practice of women artists in the 1990s was infected by post-identitarian or queer theories. The irruption of the discourses of gender dissidence came at a time when the feminist art scene was still trying to solidify after being overshadowed by forty years of dictatorship. At the same time, it explores the cultural policies of the Spanish territory and the turning point of the crisis of legitimacy in the socio-economic system that prevailed in democratic Spain after the Transition. Finally, analyzes the components that precipitated the outbreak of the political 1990s, in which feminist militancy in the contemporary visual arts, in its transfer with queer and other social movements, would be decisive in the reconfiguration of the artistic scene outside the institutional discourses
Transformación de biorresiduos florales de Crocus sativus L. en subproductos funcionales : caracterización, potencial bioactivo y aplicaciones
No full textLa presente tesis doctoral, titulada Transformacion de biorresiduos florales de Crocus sativus L. en subproductos funcionales: caracterizacion, potencial bioactivo y aplicaciones, se enmarca en el contexto de la economia circular y la sostenibilidad agroalimentaria, con el proposito de aportar soluciones innovadoras al aprovechamiento de los subproductos generados durante la produccion de azafran. Mas del 90 % de la biomasa floral del Crocus sativus, principalmente petalos, calices, estambres y tepalos, se descarta tras la recoleccion de los estigmas, generando un volumen considerable de biorresiduos con un potencial bioquimico aun poco explorado.
El objetivo general de esta investigacion fue caracterizar los biorresiduos florales del Crocus sativus L. y evaluar su potencial funcional y bioactivo para su eventual aplicacion en la formulacion de productos alimentarios de valor añadido. Para alcanzarlo, se plantearon cuatro objetivos especificos: (1) analizar las caracteristicas fisicoquimicas y microbiologicas del biorresiduo; (2) identificar y cuantificar sus principales metabolitos mediante tecnicas cromatograficas; (3) evaluar sus propiedades antioxidantes, antimicrobianas y su contenido en fitomelatonina; y (4) aplicar los extractos obtenidos en el desarrollo de una bebida vegetal fortificada, valorando su estabilidad y funcionalidad.
Metodologicamente, se emplearon procedimientos experimentales adaptados a matrices vegetales. Los biorresiduos fueron procesados en dos formatos, pulverizado y extracto metanolico, que se sometieron a analisis fisicoquimicos, microbiologicos y de caracterizacion quimica mediante HPLC-MS y GC-MS. Las propiedades antioxidantes se determinaron por los metodos ABTS, DPPH y FRAP, mientras que la actividad antimicrobiana se evaluo frente a cepas bacterianas y fungicas. El contenido en fitomelatonina se cuantifico mediante cromatografia liquida de alta eficiencia con deteccion por fluorescencia. Finalmente, los extractos fueron incorporados en bebidas vegetales comerciales, analizando su impacto en el color, el pH y el perfil antioxidante final del producto.
Los resultados demostraron que los biorresiduos florales de Crocus sativus presentan un perfil fitoquimico rico en compuestos fenolicos, flavonoides, acidos organicos y pigmentos naturales. Estos metabolitos confieren una elevada capacidad antioxidante y una notable actividad antimicrobiana, lo que sugiere su posible uso como agentes conservantes naturales. El contenido en fitomelatonina refuerza el interes de este biorresiduo como fuente de compuestos bioactivos con beneficios potenciales para la salud.
En la aplicacion practica, la incorporacion de los extractos en bebidas vegetales resulto tecnologicamente viable, modificando de forma controlada el color y el pH sin comprometer su estabilidad. Las bebidas fortificadas presentaron un incremento en la actividad antioxidante, posicionandose como un ejemplo de alimento funcional obtenido a partir de subproductos agroindustriales.
En conclusion, esta tesis evidencia que los biorresiduos florales del Crocus sativus L. constituyen una fuente sostenible y de alto valor añadido de compuestos bioactivos, con aplicaciones potenciales en las industrias alimentaria, cosmetica y nutraceutica, contribuyendo al desarrollo de una economia circular basada en la valorizacion de residuos agricolas.This doctoral thesis, entitled Transformation of floral bio-residues from Crocus sativus L. into functional by-products: characterization, bioactive potential and applications, is framed within the context of circular economy and sustainable agro-industrial innovation. Its purpose is to provide scientific and practical solutions for the valorization of floral by-products generated during saffron production. More than 90% of the Crocus sativus floral biomass, mainly petals, stamens, calyxes and tepals, is discarded after the collection of stigmas, despite representing a potentially rich source of bioactive compounds that remains largely unexplored.
The general aim of this research was to characterize the floral bio-residues of Crocus sativus L. and to evaluate their bioactive and functional potential for their use in the development of value-added food products. To achieve this, four specific objectives were defined: (1) to analyze the physicochemical and microbiological characteristics of the bio-residue; (2) to identify and quantify its main metabolites using chromatographic techniques; (3) to evaluate its antioxidant, antimicrobial and antifungal activities as well as its melatonin content; and (4) to explore its incorporation into a fortified plant-based beverage and assess its stability and functional performance.
Methodologically, the study followed rigorous experimental procedures adapted to plant matrices. The bio-residues were processed into two forms, powdered material and methanolic extract, and subjected to physicochemical (moisture, ash content, pH, colorimetry) and microbiological analyses, as well as chemical characterization through HPLC-MS and GC-MS. Antioxidant capacity was determined by ABTS, DPPH and FRAP assays, while antimicrobial activity was tested against selected bacterial and fungal strains relevant to food safety. The phytomelatonin content, a compound of growing physiological and therapeutic interest, was quantified using high-performance liquid chromatography with fluorescence detection. Finally, the extracts were incorporated into commercial plant-based beverages, evaluating their impact on color parameters, pH and antioxidant profile.
The results revealed that Crocus sativus floral bio-residues exhibit a rich phytochemical profile, containing phenolic compounds, flavonoids, organic acids and natural pigments. These compounds conferred a high antioxidant capacity, comparable to that of other plant extracts commonly used in the food and nutraceutical industries. Moreover, the extracts demonstrated notable antimicrobial and antifungal properties, suggesting their potential as natural preservative agents. The quantification of phytomelatonin, although variable between extracts, further supports the potential of this bio-residue as a valuable source of health-promoting bioactive molecules.
From an applied perspective, incorporating these extracts into plant-based beverages proved technologically feasible, inducing controlled variations in color and pH without compromising product stability. The fortified beverages showed an enhanced antioxidant activity, illustrating a successful case of a functional food developed from agro-industrial by-products.
In conclusion, this research demonstrates that the floral bio-residues of Crocus sativus L. constitute a sustainable and high-value source of bioactive compounds with potential applications across the food, cosmetic and nutraceutical industries. The findings highlight the relevance of linking phytochemical research with sustainability strategies, contributing to the advancement of a circular bioeconomy where waste is transformed into functional, innovative and socially valuable resources. This work thus provides a scientific foundation for reimagining agricultural waste as an opportunity for innovation and environmental responsibility
Next Generation EU and industrial transformation: evidence from Spain
No full textNext Generation EU (NGEU) funds represent a large-scale public investment aimed at mitigating the economic impact of COVID-19 and advancing industrial modernization across the European Union. This study analyzes their early effects in Spain through three objectives: (i) to provide an integrated overview of the design and industrial orientation of the Spain Can Plan, including the role of Industrial Policy Spain 2030 and PERTEs as mission-oriented instruments; (ii) to examine the macro-level implementation of NGEU funds across strategic policy levers, beneficiaries, and regions; and (iii) to assess how sectoral patterns and firm-level characteristics shape the absorption of support. Evidence from the ELISA and SABI databases shows pronounced territorial and sectoral asymmetries, with energy-related and capital-intensive activities receiving a high share of resources. At the firm level, funding allocation is closely linked to pre-existing structural capabilities, whilst post-COVID financial indicators point to improvements in profitability, productivity, and financial stability. The study concludes with policy recommendations to strengthen Spain’s industrial modernization and its strategic positioning in the global economy
Long non-coding RNA C20orf56 as a predictor of response to neoadjuvant CCRT and survival rates of rectal cancers
No full textIntroduction. Colorectal cancer is the third
most prevalent malignancy and the second leading cause
of cancer mortality worldwide. Neoadjuvant concurrent
chemoradiotherapy (CCRT) improves survival and
increases curative surgery rates in rectal cancer.
C20orf56, a long non-coding RNA (lncRNA), plays
diverse roles in cancer, but its association with
neoadjuvant CCRT response and prognosis in rectal
cancer remains unexplored.
Materials and Methods. Tumor samples from 343
rectal cancer patients who received neoadjuvant CCRT
followed by surgery were analyzed for C20orf56
expression via in situ hybridization. Associations
between C20orf56 expression and clinicopathological
parameters were evaluated with the χ² test. Survival
outcomes were assessed using the Kaplan-Meier method and compared by log-rank tests, while multivariate
analysis was conducted using a Cox proportional
hazards model. Additionally, an independent cohort of
responders and non-responders (n=8 per group) was
used to validate C20orf56 transcript levels by real-time
RT-PCR.
Results. A transcriptomic analysis (GSE35452)
identified C20orf56 as differentially expressed between
responders and non-responders. Decreased expression of
C20orf56 showed significant correlations with less
advanced post-treatment tumor invasiveness, negative
post-treatment nodal metastasis, absence of vascular
invasion and perineural invasion, and improved response
to neoadjuvant CCRT (all p≤0.024). Diminished
expression of C20orf56 was associated not only with
favorable disease-specific survival (DSS), local
recurrence-free survival (LRFS), and metastasis-free
survival (MeFS) (all p<0.0001) in univariate analysis but
also functioned as an independent predictor signifying
enhanced clinical outcomes, including DSS, LRFS, and
MeFS (all p<0.001). In the real-time RT-PCR analysis,
the transcriptomic levels were significantly lower in the responder group compared with the non-responder group
(p=0.007).
Conclusion. C20orf56 may play a significant role in
rectal cancer progression and response to neoadjuvant
CCRT, serving as a novel prognostic factor