MRC Lifecourse Epidemiology Unit

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    Congenital Insensitivity to Pain

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    Congenital Insensitivity to Pain belongs to the family of Hereditary Sensory and Autonomic Neuropathies (HSAN). It is a rare disorder of unknown etiology associated with loss of pain sensation. Cognition and sensation is otherwise normal and there is no detectable physical abnormality. We report a case of Congenital Insensitivity to Pain in a 3 year old female child

    Intelligent Agents in Military, Defense and Warfare: Ethical Issues and Concerns

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    Due to tremendous progress in digital electronics now intelligent and autonomous agents are gradually being adopted into the fields and domains of the military, defense and warfare. This paper tries to explore some of the inherent ethical issues, threats and some remedial issues about the impact of such systems on human civilization and existence in general. This paper discusses human ethics in contrast to machine ethics and the problems caused by non-sentient agents. A systematic study is made on paradoxes regarding the long-term advantages of such agents in military combat. This paper proposes an international standard which could be adopted by all nations to bypass the adverse effects and solve ethical issues of such intelligent agents

    Consciousness: A Simple Information Theory Global Workspace Model

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    The asymptotic limit theorems of information theory permit a concise formulation of Bernard Baars' global workspace/global broadcast picture of consciousness, focusing on how networks of unconscious cognitive modules are driven by the classic 'no free lunch' argument into shifting, tunable, alliances having variable thresholds for signal detection. The model directly accounts for the punctuated characteristics of many conscious phenomena, and derives the inherent necessity of inattentional blindness and related effects

    Evolving clinical profile of HLA-DRB1, MMP1 and NF-Κb gene in rheumatoid factor positive Caucasian population

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    Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lung disease) that may be life threatening. The reason why extra-articular features will develop in rare RA patients is unknown. Our study was aimed to find any disease correlation with respect to a few genetic loci implicated in rheumatoid arthritis. In our study no significant association was observed for NFkB1 and MMP-1. However HLA-DRB1 showed polymorphism in RA and controls. The study was conducted on 60 patients, where 30 were control and 30 were diseased. All the patients selected for the study were RF (rheumatoid factor) positive. Therefore the studies need to be conducted on larger group of patients, so that the association can be verified in Caucasian population (Indian scenario)

    Evolving clinical profile of IL-1β, IL-10 and CTLA-4 gene in rheumatoid factor positive Caucasian population

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    Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lung disease) that may be life threatening. The reason why extra-articular features will develop in rare RA patients is unknown. Our study was aimed to find any disease correlation with respect to a few genetic loci implicated in rheumatoid arthritis. In our study no significant association was observed for Il-1β and IL-10. However CTLA-4 showed polymorphism in RA and controls. In our earlier article we reported polymorphism of HLA-DRB1 in Caucasian population. The study was conducted on 60 patients, where 30 were control and 30 were diseased. All the patients selected for the study were Rf (rheumatoid factor) positive. Therefore the studies need to be conducted on larger group of patients, so that the association can be verified in Caucasian population (Indian scenario)

    Rendering of 3d Dynamic Virtual Environments

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    In this paper we present a framework for the rendering of dynamic 3D virtual environments which can be integrated in the development of videogames. It includes methods to manage sounds and particle effects, paged static geometries, the support of a physics engine and various input systems. It has been designed with a modular structure to allow future expansions. We exploited some open-source state-of-the-art components such as OGRE, PhysX, ParticleUniverse, etc.; all of them have been properly integrated to obtain peculiar physical and environmental effects. The stand-alone version of the application is fully compatible with Direct3D and OpenGL APIs and adopts OpenAL APIs to manage audio cards. Concluding, we devised a showcase demo which reproduces a dynamic 3D environment, including some particular effects: the alternation of day and night infuencing the lighting of the scene, the rendering of terrain, water and vegetation, the reproduction of sounds and atmospheric agents.\u

    Subjectivity and Objectivity in Russian Political Discourse

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    This abstract deals with the linguistic means which famous Russian political figure Vladislav Surkov uses in his speech and which has a great influence on people

    Hospital Related Stress Among Patients Admitted to a Psychiatric In-patient Unit in India

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    The psychiatric patient’s attitudes towards hospitalization have found an association between patient perceptions of the ward atmosphere and dissatisfaction. The aim of the study was to determine the aspects of stress related to hospitalization in inpatients admitted to a psychiatric facility. Fifty in-patients of both sexes admitted consecutively to a psychiatric unit in a General Hospital were asked to rate the importance of, and their satisfaction with, 38 different aspects of in-patient care and treatment. Results showed that the major sources of stress were related to having a violent patient near to his/her bed; being away from family; having to stay in closed wards; having to eat cold and tasteless food; losing income or job due to illness, being hospitalized away from home; not able to understand the jargons used by the clinical staff and not getting medication for sleep. A well-differentiated assessment of stress and satisfaction has implications for the evaluation of the quality of psychiatric care and for the improvement of in-patient psychiatric care

    Women Reproductive Rights in India: Prospective Future.

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    Reproductive rights were established as a subset of the human rights. Parents have a basic human right to determine freely and responsibly the number and the spacing of their children. Issues regarding the reproductive rights are vigorously contested, regardless of the population’s socioeconomic level, religion or culture. Following review article discusses reproductive rights with respect to Indian context focusing on socio economic and cultural aspects. Also discusses sensitization of government and judicial agencies in protecting the reproductive rights with special focus on the protecting the reproductive rights of people with disability (mental illness and mental retardation)

    Health Informatics, Sustainable Health Care Development and Malnutrition in India

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    Health informatics aims at studying the principal computer applications related to technology in developing human health care and solving the existing problems to facilitate efficient management. It helps in decision making process, hospital administration and system management and in catering the needs of clients/patients and doctors. However, the inadequacy of skilled manpower, resources and economy are the major hurdles to exploit the full potential of the technology and medical health facilities. Malnutrition and related causes are adversely affecting the nation from several angles. An integral approach would be able to mitigate the human sufferings

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