MRC Lifecourse Epidemiology Unit

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    Uner Tan Syndrome: Review and Emergence of Human Quadrupedalism in Self-Organization, Attarctors and evolutionary Perspectives

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    Uner Tan syndrome, discovered in 2005 by Dr. Tan, in Southern Turkey, mainly consists of habitual quadrupedal locomotioni impaired intelligence, and dysarthric or no speech, with or without (rarely) cerebello-vermial hypoplasia and mildly simplified cortical gyri. \ud This syndrome may be considered wthin the framework of the nonprogressive autosomal recessive cerebellar ataxias, associated with various genetic mutations (genetic heterogeneity). This is a unique condition among disequilibrium syndrome, Cayman ataxia, and Joubert syndrome. \ud From the viewpoint of dynamical systems theory, there may be not a single factor including a ganetic code that predetermines the emergence of human quıadrupedalism, seen for instance in Uner Tan syndrome. Rather it may involve self-organization process, consisting of many decentralized and local interactions among neuronal, genetic, and environmental subsystems

    Stress Among Health Care Professionals - The Need for Resiliency

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    Healthcare professionals are subjected to considerable levels of stress such as work overload, excessive working hours, sleep deprivation, repeated exposure to emotionally charged situations, dealing with difficult patients and conflicts with other staffs. Management of such stress should be given due importance, right from the days of training in medical sciences

    Recall termination in free recall

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    Although much is known about the dynamics of\ud memory search in the free recall task, relatively little is\ud known about the factors related to recall termination. Rean-\ud alyzing individual trial data from 14 prior studies (1,079\ud participants in 28,015 trials) and defining termination as\ud occurring when a final response is followed by a long\ud nonresponse interval, we observed that termination proba-\ud bility increased throughout the recall period and that retriev-\ud al was more likely to terminate following an error than\ud following a correct response. Among errors, termination\ud probability was higher following prior-list intrusions and\ud repetitions than following extralist intrusions. To verify that\ud this pattern of results can be seen in a single study, we report\ud a new experiment in which 80 participants contributed recall\ud data from a total of 9,122 trials. This experiment replicated\ud the pattern observed in the aggregate analysis of the prior\ud studies.\u

    The Processing of Lexical Sequences

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    Psycholinguistics has traditionally been defined as the study of how we process units of language such as letters, words and sentences. But what about other units? This dissertation concerns itself with short lexical sequences called n- grams, longer than words but shorter than most sentences. N-grams can be phrases (such as the 3-gram "the great divide") or just fragments (such as the 4- gram means "nothing to a"). Words are often thought to be the universal, atomic building block of longer lexical sequences, but n-grams are equally capable of carrying meaning and being combined to create any sentence. Are n-grams more than just the sum of their parts (the sum of their words)? How do language users process n-grams when they are asked to read them or produce them? Using evidence that I have gathered, I will address these and other questions with the goal of better understanding n-gram processing

    Postpartum Mental Health among Young Women

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    Background: A number of studies have highlighted the physical health problems associated with adolescent pregnancy in Saudi Arabia , However there were few studies dealing with the postpartum psychiatric disorders .The study aims to determine the prevalence of postpartum psychological distress and to evaluate the associated risk factors in a sample of primigravid young women in Al Ahsa region, Saudi Arabia. Methods: We assessed the prevalence of postnatal mental health in 190 young mothers attending the maternity hospital using general health questionnaire. We also assessed the relationship between socio-demographic, psychiatric and obstetric risk factors and the mental health. Results: The percent of women with psychological distress was 35.2%. Significant risk of psychological distress was associated with several socio-demographic, psychiatric and obstetric risk factors. Only four items were found to be significant predictors of postpartum psychological distress; low family income, poor husband support, birth of female baby and gestational diabetes. Conclusions: These results highlighted importance of screening for psychological distress and its associated risk factors in the implementation of proper perinatal care for the pregnant Saudi adolescents

    Healthcare Data Analytics on the Cloud

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    Meaningful analysis of voluminous health information has always been a challenge in most healthcare organizations. Accurate and timely information required by the management to lead a healthcare organization through the challenges found in the industry can be obtained using business intelligence (BI) or business analytics tools. However, these require large capital investments to implement and support the large volumes of data that needs to be analyzed to identify trends. They also require enormous processing power which places pressure on the business resources in addition to the dynamic changes in the digital technology. This paper evaluates the various nuances of business analytics of healthcare hosted on the cloud computing environment. The paper explores BI being offered as Software as a Service (SaaS) solution towards offering meaningful use of information for improving functions in healthcare enterprise. It also attempts to identify the challenges that healthcare enterprises face when making use of a BI SaaS solution

    Risk Factors of Diabetes Mellitus in Rural Puducherry

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    Purpose: Prevalence of type 2 diabetes is increasing in India. Rural area constitutes 80% of India. Hence it is essential to understand the epidemiology for appropriate interventions. Objectives: to identify risk factors of type 2 diabetes mellitus in rural Puducherry. Methodology: Cross sectional study in two villages of Puducherry, India. 1403 subjects above 25 years from 2 villages. Study measured demographic variables, Body Mass Index (BMI), physical activity, family history of Diabetes Mellitus, smoking and alcohol consumption. Fasting blood glucose was measured for study subjects. Further, those with >126 mg/dl were subjected for Oral Glucose Tolerance Test. Univariate and multivariate analysis was done. Receiver Operating characteristic Curve was plotted to find out cut off for Diabetic Risk Score. Findings: The prevalence of type 2 Diabetes Mellitus (DM) was 5.8%. The response rate was (88%). In univariate analysis age, occupation, Socio Economic Status, BMI, physical activity, family history were significant for DM. In multivariate analysis age, BMI, family history of diabetes and occupation were significant for type 2 DM. The ‘diabetes risk score’ generated by the study using age, BMI and family history of DM, had specificity, sensitivity and accuracy of 54%, 77% and 76.2% respectively. The area under curve for scoring system was 0.784 (<0.05). Conclusions: Identified risk factors are useful for early diagnosis by using ‘diabetes risk score’ – thus uncovering the iceberg of disease

    Primary Signet-Ring Carcinoma (Linitus Plastica) of the Colorectum presenting as Subacute Intestinal Obstruction

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    Primary Signet-ring cell carcinoma (Linitus Plastica) of the colon and rectum is a rare form of adenocarcinoma of the large intestine and has been reported to have an extremely poor prognosis. We report a case of Primary Signet-ring cell carcinoma of the colorectum in a thirty one year old man presented in Surgical OPD of our hospital with chief complaints of persistent pain in abdomen and vomiting since two days. Since the prognosis of primary signet ring cell carcinoma (SRCC) is extremely poor (in view of more malignant behavior than ordinary colorectal carcinoma), early diagnosis and aggressive treatment strategy are necessary

    Reaching Community Through School Going Children for Sickle Cell Disease in Zankhvav Village of Surat District, Western India

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    Objectives: The objective of the study was to explore a method to reach the community via school going adolescents for screening tribal people for Sickle Cell disease. Methodology: A cross-sectional study was conducted in a total of 1023 school going adolescents for Sickle Cell Disease screening by Dithionite Tube Turbidity (DTT) test with subsequent Hemoglobin Electrophoresis for confirmation among those testing positive for DTT. They were then advised to get their family members tested for the same. Results: 24.41% of school going adolescents tested positive by DTT test. 152 family members of those positive school children came forward for testing. On performing the DTT test on the family members, 53.94% tested positive. Out of those who tested positive, 61% belonged to Vasava caste; 36.6% belonged to Chaudhari caste followed by Gamit and Dhodhia Patel. On the subsequent Hemoglobin electrophoresis, 52.63% of the family members were found to be positive for Sickle Cell Trait and 1.97% tested positive for Sickle Cell Disease. Conclusions: School going children can be an effective medium to approach the community for the screening of Sickle Cell Disease

    Scrub Typhus Presenting as Acute Myocardial Infarction.

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    Scrub Typhus, or tsutsugamushi disease is a febrile illness caused by bacteria of the family Rickettsiaceae and named Orientia tsutsugamushi. Recently it has been found to endemic in Subhimalayan region of India. Scrub typhus affects skeletal muscles, skin, lungs, kidneys, brain and cardiac muscles.We report a rare case of scrub typhus presenting as acute myocardial infarction

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