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Assessment of the feed additives menadione sodium bisulphite (3a710) and menadione nicotinamide bisulphite (3a711) (vitamin K<sub>3</sub>) for all animal species for the renewal of their authorisation (DSM Nutritional Products Ltd, KH Boddin GmbH, Oxyvit Kimya San. Ve Tic. A.Ş., Orffa Additives BV, FNF Ingredients EU BV, ADM International SàRL)
No full textFollowing a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for the renewal of the authorisation of vitamin K3 in the form of menadione sodium bisulphite (MSB) and menadione nicotinamide bisulphite (MNB) as nutritional feed additives. The additives MSB (3a710) and MNB (3a711) are currently authorised for use in all animal species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the use of vitamin K3 in the form of MSB and MNB remains safe for the target animals, consumer and for the environment under the approved conditions of the authorisation. Regarding user safety, the Panel concluded that exposure by any route is considered a risk and should be minimised. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.</p
Assessment of the feed additive consisting of 6-phytase (produced with Trichoderma reesei CBS 126897) (Quantum® Blue) for the renewal of its authorisation for poultry, weaned piglets, pigs for fattening and sows (4a19), and its extension of use to other porcine species and ornamental birds (AB Enzymes Finland Oy)
No full textFollowing a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of 6-phytase produced with a genetically modified strain of Trichoderma reesei (CBS 126897) (Quantum® Blue) as a zootechnical feed additive for poultry, piglets, pigs for fattening and sows, other porcine species and ornamental birds. The additive is currently authorised for use in feed for laying birds, poultry other than laying birds, weaned piglets, pigs for fattening and sows. This scientific opinion concerns the request for the renewal of the authorisation of the additive for these species and the extension of use to suckling piglets and other porcine species and ornamental birds. The additive is available in two solid (Quantum® Blue 5 G and 40 P) and two liquid formulations (Quantum® Blue 5 and 10 L). Some changes in the composition of the product have been implemented since the first authorisation. The applicant provided evidence that the additive complies with the terms of the authorisation. The FEEDAP Panel concluded that all formulations of the additive remain safe for the target species, consumers and the environment, and that the extension of use to the new species would not affect these conclusions. Regarding user safety, all the forms of the additive should be considered as respiratory sensitisers. The solid forms of the additive are dust free; therefore, the exposure of users through inhalation is unlikely. No specific information was submitted for the four formulations of the additive under assessment regarding their potential to be skin and eye irritants and skin sensitisers. In the absence of data, the FEEDAP Panel is not in the position to conclude on the potential of the additive to be skin and eye irritants or skin sensitisers. There is no need for the assessment of efficacy in poultry, weaned piglets, pigs for fattening and sows in the context of the renewal of the authorisation. The FEEDAP Panel considers that the additive has the potential to be efficacious in ornamental birds at 250 FTU/kg complete feed and in suckling piglets and in suckling and weaned piglets of minor porcine species at 500 FTU/kg and in minor porcine species for fattening/reared for reproduction and reproductive animals at 250 FTU/kg complete feed.</p
Efficient numerical integration of rigid body dynamics
No full textIntegrating equations of motion is a crucial aspect of discrete element method (DEM) simulations. However, this integration can be particularly challenging when dealing with rigid body dynamics. In this work, we review Spiral, a third-order integration algorithm designed for the rotational motion of extended bodies. Spiral offers stability and precision, surpassing commonly used algorithms. Furthermore, Spiral addresses many challenges associated with rotation dynamics in leading DEM codes, such as YADE, MERCURY DPM, LIGGGHTS, and PFC, without compromising performance. This algorithm eliminates the need for quaternion normalization at each time step, requires only one force calculation per time step, and is compatible with both leapfrog and synchronous integration methods.</p
Corrigendum to "Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis". [Eur. J. Pharm. Biopharm. 154 (2020) 50-61]
No full textMy Diabetes and Me: Study protocol for a randomised controlled trial to test the clinical and cost-effectiveness of a diabetes self-management education programme for adults with intellectual disabilities
No full textBackgroundInternational guidelines recommend structured diabetes education to empower individuals with type 2 diabetes (T2D). While DESMOND is an effective programme for T2D management, it is often inaccessible to people with intellectual disabilities (ID) due to their unique needs. There is limited evidence on the effectiveness of adapted T2D education for this group, despite the importance of tailored support in preventing complications and early mortality. We previously adapted the DESMOND programme for adults with ID, creating DESMOND-ID. A feasibility study showed it is possible to recruit and deliver the programme to adults with ID and their carers, who found it valuable. Initial findings suggest DESMOND-ID may improve blood glucose control, warranting further investigation through a large-scale randomised controlled trial (RCT).MethodsThe "My Diabetes & Me" study will be conducted in two stages: an internal pilot and a main RCT. The pilot will recruit 108 participants over 10 months to assess recruitment and retention, using glycated haemoglobin (HbA1c, mmol/mol) at six months as the primary outcome. This will inform the design of the main study. Across both stages, 450 participants will be randomly assigned to receive either the DESMOND-ID intervention or treatment as usual (TAU). The intervention group, with their carers, will attend weekly sessions for seven weeks, plus two booster sessions at one and three months post-programme. Primary outcome is HbA1c at six months. Secondary outcomes include HbA1c at 12 and 18 months (pilot only), anthropometric data, self-reported outcomes, and other risk factors. A process evaluation will explore barriers and facilitators to implementation using qualitative and quantitative methods.ConclusionDESMOND-ID is the first structured T2D education programme tailored for adults with ID, and this RCT is the first to evaluate its clinical and cost-effectiveness
The Afters (Jenna's Story and Charlie's Story)
No full textThe Afters is a drama narrative in Virtual Reality intended for use in Relationship and Sex Education. It is 2 x 10 minute films from (i) a male and (ii) female 17 year old perspective, of the same sexual interaction. These two research films will gauge understanding of topics such as bodily autonomy, boundaries and peer and digital influence, and create discussions around how immersive technologies might be useful for facilitation and delivery of RSE by teachers
Accelerated analytical model for energy storage capacity value assessment
No full textEnergy storage systems(ESS) has becoming increasingly important to provide system reliability under elevated renewable penetration. Accurate assessment of the capacity credit of EES has been constrained by computational complexity of operational details related to hourly renewable variability and system flexibility. This paper presents a novel analytical framework for evaluating the capacity credit of ESS incorporating detailed unit commitment model and multi-year renewable variability. The methodology integrates a single-layer optimization framework eliminating iterative convergence, a fast unit commitment-based reliability evaluation, and a scenario reduction algorithm preserving critical statistical characteristics. Case studies on typical Chinese provincial power system demonstrate the proposed model reduce computational time by 86% while maintaining 99.8% accuracy compared with conventional methods. Results show that storage capacity value depends significantly on duration, storage-to-renewable ratio, and inter-annual renewable variability. The framework provides system planners with an efficient tool for ESS capacity adequacy assessments in renewable-dominated power systems.<br/
Secondary analysis of the Game of Stones trial for men with obesity: examining moderator effects and exploratory outcomes
No full textObjectiveThe objective was to explore whether socioeconomic, health, and behavioral characteristics moderate the effectiveness of a text message intervention with or without financial incentives versus a control group and to examine differences in exploratory outcomes.MethodsThis three‐group randomized trial including 585 men with obesity compared daily automated behavioral text messages alongside financial incentives, text messages alone, and a waiting list control for 12 months. Moderator analyses examined percentage weight change after 12 months for 9 socioeconomic and 11 health factors. Exploratory outcomes included the following: self‐reported physical activity, sedentary behavior, smoking and alcohol behaviors, engagement in 15 weight‐management strategies, and weight‐management–related confidence.ResultsNo moderator effects were found by any factors for either comparison versus control. There were no differences across groups for health behaviors. The texts with incentives group had higher levels of engagement in six strategies including weight goals, food changes, and self‐weighing and higher levels of confidence compared with the control.ConclusionsThe Game of Stones interventions were equally effective across various subgroups based on socioeconomic, health, or well‐being status. Texts with financial incentives group participants showed better engagement for some intervention elements. The implementation of Game of Stones is unlikely to increase health inequalities. Future studies should focus on increasing engagement
Predictions of the LSST solar system yield: near-earth objects, main belt asteroids, Jupiter trojans, and trans-Neptunian objects
No full textThe NSF-DOE Vera C. Rubin Observatory is a new 8m-class survey facility presently being commissioned in Chile, expected to begin the 10 yr long Legacy Survey of Space and Time (LSST) by the end of 2025. Using the purpose-built Sorcha survey simulator, and near-final observing cadence, we perform the first high-fidelity simulation of LSST’s solar system catalog for key small body populations. We show that the final LSST catalog will deliver over 1.1 billion observations of small bodies and raise the number of known objects to 1.27E5 near-Earth objects, 5.09E6 main belt asteroids, 1.09E5 Jupiter Trojans, and 3.70E4 trans-Neptunian objects. These represent 4×−9× more objects than are presently known in each class, making LSST the largest source of data for small body science in this and the following decade. We characterize the measurements available for these populations, including orbits, griz colors, and light curves, and point out science opportunities they open. Importantly, we show that ∼70% of the main asteroid belt and more distant populations will be discovered in the first 2 yr of the survey, making high-impact solar system science possible from very early on. We make our simulated LSST catalog publicly available, allowing researchers to test their methods on an up-to-date, representative, full-scale simulation of LSST data.<br/
Recommendations for the Vera C. Rubin Observatory early science schedule
No full textThe NSF-DOE Vera C. Rubin Observatory announced plans to modify the release timetable for the final data preview (DP2) and its first data release (DR1). The Observatory solicited community feedback regarding potential paths forward, as supplied by the Observatory, in light of the schedule change. In this Note, the Rubin Observatory LSST Solar System Science Collaboration provides its feedback concerning these options and the impact on solar system science. We strongly favor transition into survey operations and the release of the existing Science Validation commissioning data and alerts at the earliest possible opportunity