Biodiversity Informatics
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Axion Physics in UPC and LbyL Scattering
Get PDFIn this work, we revisited the light-by-light scattering physics in ultraperipheral collisions. Furthermore, an extension model with axion-like particles is also studied. We used MadGraph5\_aMC@NLO+gamma-UPC event generator for our analysis and the proposed kinematic cuts for the ALICE 3 experiment were considered. Different distribution functions for both light-by-light and axion-like particles are analyzed and we find that the transverse momentum is a good channel to observe the production of axions in ultraperipheral collisions
Protein coding circular RNAs in Human Diseases
Get PDFCircular RNAs (circRNAs) are a unique class of closed-loop RNA molecules formed through back-splicing of precursor mRNAs that exhibit diverse biological functions. Recent evidence highlights their emerging roles as protein-coding entities, particularly in cancer biology. This review explores the cap-independent translation mechanisms of circRNAs, focusing on internal ribosome entry sites and N6-methyladenosine modifications. We further summarize the biological roles of circRNA-encoded proteins and their relevance to human diseases. Additionally, the review addresses key challenges in circRNA research and provides perspectives on their promising potential in disease diagnosis and therapeutic applications
Targeting Lin28: Insights into Biology and Advances with AI-Driven Drug Development
Get PDFLin28, a conserved RNA-binding protein, promotes cancer stem cell features, epithelial-to-mesenchymal transition, and treatment resistance. Lin28 regulates mRNA translation, RNA stability, and transcription, which improve tumor plasticity and treatment resistance, in addition to suppressing let-7 microRNA production. Lin28 is an interesting cancer target due to its many functions; however, its structural complexity makes treatment development difficult. Lin28\u27s proven and new non-canonical activities in cancer biology are examined in this work, focusing on cancer stem cell maintenance, metastasis, and treatment resistance. We highlight computational drug discovery advances targeting Lin28 utilizing virtual screening and machine learning. Generative artificial intelligence has made it easier to develop inhibitors for challenging targets like Lin28. This work integrates current knowledge and technology to demonstrate Lin28\u27s therapeutic potential and outline future techniques to overcome RNA-binding protein targeting challenges
Comparative Analysis of the Incidence, Diagnosis and Treatment of Prostate Cancer between China and the United States
Get PDFIn the context of globalization and an aging population, prostate cancer has emerged as a significant threat to male health, with its incidence and mortality rates on the rise worldwide. Particularly in comparison between China and the United States, two representative countries, there are notable differences in the incidence, diagnosis, and treatment of prostate cancer due to variations in medical resource allocation, diagnostic techniques, lifestyles, and cultural perceptions. This article aims to compare and analyze the current status of prostate cancer in China and the U.S., explore the key factors influencing these differences, and provide references for the development of prostate cancer prevention and control strategies in China. We employ multi-dimensional data collection and analysis approaches including literature review, case-control studies, and statistical analysis. We focus on the epidemiological data, clinical practice guidelines, patient quality of life, and medical economic burden to comprehensively dissect the differences and their causes in prostate cancer management between China and the U.S. Our findings highlight the disparities between the two countries in the aspects of early screening, treatment preference, and long-term follow-up mechanisms, aiming to uncover the underlying reasons behind these differences and propose corresponding improvement suggestions. Conclusions drawn from our analyses indicate that the U.S. is relatively advanced in early diagnosis and personalized treatment of prostate cancer, benefiting from a more comprehensive healthcare system and advanced medical technologies. Although China has made a significant progress in recent years, it still faces many challenges due to the uneven distribution of medical resources, and there is space for improvement in public health awareness. The significance of our analysis lies in providing empirical evidence for formulating more scientifically sound and reasonable strategies for the prevention and control of prostate cancer in China, which will help promote further development and improvement in this field
Época 60: Dramaturgias universitarias, reformas del paisaje (Chile, 1941-1973)
No full text¿Época 60? Tal cual, con este tropo, denomino al periodo en que la sociedad chilena, impulsada por gobiernos sobre todo de izquierda (E. Frei, S. Allende), reinventa los contornos de su paisaje mediante leyes de reforma agraria (1962, 1967, 1970) y nacionalización de recursos naturales (1964, 1971). Con el impulso de estas leyes, en la época 60, en latifundios y yacimientos mineros, el Estado instala formas de convivencia que permiten comenzar a superar las dinámicas de producción agrícola, ganadera o minera derivadas de la encomienda y de la mita coloniales. Sostengo, pues, que semejantes reformas fueron posibles toda vez que, desde las décadas previas (1940, 1950), los teatros fundados en las universidades de vocación pública promovieron, como utopías por venir, dramaturgias que, entonces, parecieron guiones de futuro; si se quiere, estos teatros diseminaron textos cuyas didascalias ensancharon los límites de lo posible. Siguiendo esta premisa, en este ensayo, someto a escrutinio las tramas político-institucionales que hicieron posible la instalación efectiva de semejante empresa teatral
Treatise Online no. 186: Part R, Revised, Volume 1. Evolutionary history of decapod groups: Anomura
No full textStandardized protocol for collecting bee samples to generate molecular data
Get PDFThis protocol provides guidance on the appropriate collection of bee specimens or tissue samples for molecular analysis, with an emphasis on generating genetic and genomic data while ensuring tissue integrity. Specifically, the protocol focuses on tissue collection and storage methods, including relevant specimen metadata recording and reporting, but does not cover any downstream handling or analyses, which vary depending on the aims of a given project or study. This protocol is specifically designed for freshly collected, individual bee specimens intended for genetic, genomic, or other molecular analyses. While molecular approaches to bee monitoring are not the primary focus, we emphasize their promising role for future applications. This protocol is part of a series developed in association with the U.S. National Native Bee Monitoring Network to standardize bee monitoring practices.
