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Predation on Gliding Treefrog (Agalychnis spurrelli) eggs by Central American White-faced Capuchins (Cebus imitator) on Costa Rica’s Osa Peninsula
Get PDFPredation on the Splendid Fanged Frog Limnonectes splendissimus by the Dak Krong Mud Snake Myrrophis dakkrongensis in Lam Dong Province, Vietnam
No full textAurora kinase A in urological cancers
Get PDFAurora kinases are a family of serine/threonine kinases of whom function to preserve the integrity and fidelity of chromosomal segregation. In mammals, aurora kinase A (AurkA) is vital to the mitotic phase of the cell cycle as a consequence of its spatial and timely interactions with various types of cell cycle substrates. Since AurkA is present in all of the mammalian somatic cell cycles, it is also detectable in many different types and stages of cancers. Specific activation sites, feedback loops, and substrate interactions have been identified and linked to the progression of urological cancers. It is inarguable that the slightest hint of disorder among AurkA can disrupt the cell cycle’s ability to regulate the growth and progression of cells in all conditions due to its direct interactions with tumor suppressing molecules. Discovering that AurkA interacts with FOXO3a, PLK1, TPX2, TPX2, SPOP, YBX1 and CXCR7 in ways that were unknown before 2019 has revealed new targeted treatment options that may surpass current methodology in efficiency and length of remission. The aim of this paper is to highlight AurkA’s oncogenic role in urological cancers, in addition to emphasizing newfound pathways and mechanisms that introduce the prostate cancer research field to more options for therapeutic approaches
Emerging Mechanisms Linking High-Fat Diet and Endometrial Cancer: Insights into the Role of Gut Microbiota and Metabolic Dysregulation
Get PDFHigh-fat diet (HFD) consumption has been recognized as a significant risk factor for the development of endometrial carcinoma (EC). Emerging research highlights gut microbiota as crucial mediators of HFD-induced systemic effects, which not only promote metabolic disorders such as obesity, insulin resistance, and systemic inflammation but also lead to profound alterations in gut microbiota composition. These changes subsequently influence estrogen metabolism, inflammatory signaling pathways, and endometrial remodeling, thereby exacerbating cellular proliferation and atypical changes within the endometrium. The underlying mechanisms may involve dysbiotic shifts in intestinal flora that contribute to increased endotoxemia, compromised intestinal barrier function, and chronic low-grade inflammation. This review synthesizes current findings on how HFD-induced gut microbiota dysbiosis and metabolic dysregulation contribute to the pathogenesis of EC while highlighting potential preventive and therapeutic strategies
Effects of Interleukin-17 on Expression of CD40 and CD40L in T and B Cell Lines
No full textInterleukin-17 (IL-17, also known as IL-17A) plays a role in immune regulation and pathogenesis of various diseases. Cluster of differentiation 40 (CD40) and its ligand CD40L are critical for T and B cell communications and activation of immune responses. This study investigated the effects of IL-17A on CD40L expression in Jurkat T cells and CD40 expression in Mino B cells. The cells were treated with IL-17A (40 ng/mL for Jurkat cells and 20 ng/mL for Mino cells) for durations ranging from 0 to 24 hours. Protein expression levels were assessed using Western blotting combined with densitometric analysis. IL-17A treatment resulted in an increase in CD40L expression in Jurkat cells, although this change did not reach statistical significance (P > 0.05). In contrast, CD40 expression in Mino cells was significantly decreased at 24 h compared to the control group (*P < 0.05). These findings indicate that IL-17A differentially regulates the expression of co-stimulatory molecules in T and B cells, potentially contributing to its modulatory effects on T–B cell interactions
USCACA Call For 2026 AACR and ASCO Travel Awards
No full textThe U.S. Chinese Anti-Cancer Association (USCACA) is pleased to announce the call for nominations for the 2026 USCACA Travel Awards to support attendance at the 2026 AACR and ASCO Annual Meetings. These awards will recognize 2 to 5 outstanding junior Chinese investigators who have been selected for an oral presentation at either the 2026 AACR or 2026 ASCO Annual Meeting. Awardees will be selected based on the significance of their scientific contributions in basic, translational, or clinical cancer research as reflected in their accepted oral presentations
Vector meson production in ultraperipheral heavy ion collisions
Get PDFWe review model calculations of exclusive vector meson production in ultraperipheral heavy ion collisions. We highlight differences and similarities between different dipole models and leading twist shadowing calculations. Recent color glass condensate calculations are presented with focus on effects from nuclear structure and azimuthal anisotropies driven by interference effects
Impact parameter dependence of dilepton production: Wigner function approach and the role of photon polarizations
Get PDFWe revisit the Wigner function approach to the impact parameter dependent dilepton pair production developed in [M. Klusek-Gawenda, WS, A. Szczurek Phys. Lett. B 814 (2021) 136114]. We study the distribution of the angle between difference and sum of lepton transverse momenta, and show how it relates to the orbital angular momentum of leptons. The dependence on impact paramter is discussed, and we also present the different components of the Wigner function in the t-channel. A brief comparison to similar angular distributions in diffractive quark pair production will be presented
Nuclear Shadowing in inelastic photon-nucleus scattering in UPCs with forward neutrons
Get PDFWe argue that measurements of forward neutrons from nuclear breakup in inclusive high energy photon-nucleus (photon-A) scattering provide a novel complementary way to study small-x dynamics of QCD in heavy-ion ultraperipheral collisions (UPCs). Using the leading twist approach to nuclear shadowing, we calculate the distribution over the number of evaporation neutrons produced in photon-lead collisions at the LHC. We demonstrate that it allows one to determine the distribution over the number of wounded nucleons (inelastic collisions), which constrains the mechanism of nuclear shadowing of nuclear parton distributions and gives an access to their impact parameter dependence
UPC physics with ALICE in Run 3
Get PDFThe ALICE experiment has undergone a major detector upgrade for Run 3, expanding its detection capabilities for a wide variety of studies. The new continuous readout has significantly enhanced the physics potential for ultra-peripheral collision analyses. In this talk, we discussed some of the physics analyses that can be carried out in ultra-peripheral collisions using the Run 3 data and presented some of the first physics performance plots in both proton-proton and heavy-ion collisions