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A Case of Tumor-to-Tumor Metastasis: Breast Carcinoma Metastatic to Oncocytic Carcinoma of Thyroid
Get PDFNear Fiber Electromyography in the Diagnosis of Myasthenia Gravis: NFEMG in MG
No full textBackground:
Near fiber EMG (NFEMG) focuses on activity of muscle fibers close to the electrode offers the ability to semi-automatically assess neuromuscular junction instability in a manner conceptually similar to single fiber EMG (SFEMG). The objective of this retrospective study was to compare the accuracy of NFEMG with SFEMG in diagnosing myasthenia gravis (MG).
Methods:
NFEMG was blindly applied to recordings from 50 patients SFEMG-tested at BIDMC in the prior 18 months, 12 of whom were diagnosed as having MG. Excluding the myopathic and neurogenic patients, NFEMG and SFEMG results were compared to the final clinical diagnosis using cross-validation that involved 10 randomly selected training sets and their corresponding testing sets.
Results:
In patients free of myopathy or neuropathy, NFEMG sensitivity was 100% while specificity ranged from 89% to 95% (mean of 90%). When testing on the entire cohort of patients free of other neuromuscular conditions, NFEMG sensitivity and specificity were 100% and 94%, respectively, while SFEMG sensitivity and specificity were 94% and 97%, respectively.
Conclusion:
NFEMG performs well in diagnosing MG, but prospective studies are needed. Patients with weakness for whom the differential diagnosis includes seronegative MG is substantial; an efficient way to address this is important. The ease of application and minimal training requirement suggest NFEMG could be an efficient screen prior to SFEMG referral or an alternative diagnostic test when SFEMG is unavailable, potentially addressing a significant healthcare disparity for the large population of patients with weakness that may be caused by seronegative MG
Bariatric surgery as a potential trigger for worsening hereditary spastic paraparesis: Case report
Get PDFWe report a patient with c.1246C>T (p.R416C) heterozygous variant on the ATL1 gene causing a complicated form of hereditary spastic paraparesis (HSP) who had an early age of onset but had non-progressive disease until a rapid decline at age 57 after bariatric surgery. To our knowledge, there have been no studies or case reports documenting a trigger for clinical worsening in patients with HSP
Mass stranding of Pelagic Seasnakes, Hydrophis platurus (Squamata: Hydrophiidae),in Guanacaste, Costa Rica
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Resisting Erasure: A Critical Review: Book review of The Untold Story of the Golan Heights: Occupation, Colonization, and Jawlani Resistance by Dajani, Muna, Fakher Eldin, Munir, and Mason, Michael, 2022
No full textThis book review examines The Untold Story of the Golan Heights, which highlights the Jawlani Druze experience under Israeli occupation. The book explores identity, resistance, and survival through a decolonial and interdisciplinary lens, challenging dominant narratives. It offers valuable insights into the region’s complex realities.
تتناول هذه المراجعة كتاب "القصة غير المروية عن هضبة الجولان"، والتي تسلط الضوء على تجربة دروز الجولان تحت الاحتلال الإسرائيلي. يستكشف الكتاب مواضيع الهوية والمقاومة والبقاء من خلال إطار متعدد التخصصات، متحديًا السرديات السائدة. الكتاب يطرح رؤى قيمة حول الحقائق المعقدة في المنطقة
Photoproduction of J/ψ and dileptons in Pb–Pb collisions with nuclear overlap
Get PDFPhoton-photon reactions and the production of J/ψ meson through photonuclear reactions have been extensively studied in ultra-peripheral heavy-ion collisions, in which the impact parameter is larger than twice the nuclear radius. In recent years, coherently photoproduced J/ψ and dilepton production via photon-photon interactions have also been observed in nucleus-nucleus (A–A) collisions with nuclear overlap. The former can help to constrain the nuclear gluon distributions at low Bjorken-x and high energy, while the latter could be used to further map the electromagnetic fields produced in heavy-ion collisions. In addition, these measurements can shed light on the theory behind photon-induced reactions in A–A collisions with nuclear overlap, including possible interactions of the measured probes with the formed and fast expanding quark-gluon plasma.
Since the produced quarkonium is expected to keep the polarization of the incoming photon due to s-channel helicity conservation, the photoproduction origin of the J/ψ yield excess at very low transverse momentum, pT, can be confirmed by the measurement of the J/ψ polarization.
The ALICE detector can perform quarkonium production measurements at both mid (|y|<0.9) and forward (2.5<y<4) rapidities down to pT = 0. In the following, the new ALICE measurements of the J/ψ y-differential cross section and the first polarization results of coherently photoproduced J/ψ via the dimuon decay channel at forward rapidity in Pb–Pb collisions at √sNN = 5.02 TeV are reported. Additionally, the measurement of an excess with respect to expectations from hadronic production in the dielectron yield, at low mass and pT, at midrapidity in Pb–Pb collisions at √sNN = 5.02 TeV, is presented. The results are compared with available theoretical models
