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Advancing knowledge of microbiallymediated lignocellulose degradation in soil using metagenomics and high-throughput in situ cultivation
Get PDFExploring the Cost, Long-Term Outcomes and Sibling Benefits of the Incredible Years (IY) Autism Spectrum and Language Delays Programme
Get PDFTemperature affects predation of schistosome-competent snails by a novel invader, the marbled crayfish Procambarus virginalis
Get PDFThe human burden of environmentally transmitted infectious diseases can depend strongly on ecological factors, including the presence or absence of natural enemies. The marbled crayfish (Procambarus virginalis) is a novel invasive species that can tolerate a wide range of ecological conditions and colonize diverse habitats. Marbled crayfish first appeared in Madagascar in 2005 and quickly spread across the country, overlapping with the distribution of freshwater snails that serve as the intermediate host of schistosomiasis-a parasitic disease of poverty with human prevalence ranging up to 94% in Madagascar. It has been hypothesized that the marbled crayfish may serve as a predator of schistosome-competent snails in areas where native predators cannot and yet no systematic study to date has been conducted to estimate its predation rate on snails. Here, we experimentally assessed marbled crayfish consumption of uninfected and infected schistosome-competent snails (Biomphalaria glabrata and Bulinus truncatus) across a range of temperatures, reflective of the habitat range of the marbled crayfish in Madagascar. We found that the relationship between crayfish consumption and temperature is unimodal with a peak at ~27.5°C. Per-capita consumption increased with body size and was not affected either by snail species or their infectious status. We detected a possible satiation effect, i.e., a small but significant reduction in per-capita consumption rate over the 72-hour duration of the predation experiment. Our results suggest that ecological parameters, such as temperature and crayfish weight, influence rates of consumption and, in turn, the potential impact of the marbled crayfish invasion on snail host populations.</p
Exploring regional coastal sediment pathways using a coupled tide-wave-sediment dynamics model
Get PDFKnowledge of sediment transport pathways is important for coastal management as well as for offshore infrastructure such as wind farms and other renewable energy installations. Here a three-way coupled model of tides, waves and sediment dynamics is presented, which extends theapproach of Davies and Robins (2017) for the prediction of the locally-varying seabed roughness ks resulting from the interaction between the flow (tides and waves) and the bed sediment (grain size mixture) subject to wave-current interaction (WCI) at the seabed. The model was applied to the North Wales coastal area, with particular emphasis on an extensive shore-connected sand bank (Constable Bank), the stability of which was investigated through the study of residual sediment circulation patterns. Multi-beam (MBES) and seabed rig (AWAC) observations have allowed validation of the predicted ks and hydrodynamics, respectively. With due allowance for the supply ofmobile sediment, the agreement between predicted ks and observed bedform height was generally good. The model has been used to determine residual velocities and sediment pathways, both with and without wave effects included. Wave influence and WCI are predominant in nearshore areas,affecting the magnitude and direction of the residual fluxes. A key modelling outcome offshore is a clockwise residual circulation pattern for water and sediment around the end of Constable Bank, set within a generally eastward net drift of sediment in the wider study are
Well-being and language: language as a well-being objective in Wales
Get PDFIncreasingly, it is recognised that the opportunity to engage with one’s own culture and language is beneficial for an individual’s well-being. Research among indigenous communities in North America, Australia, Scandinavia, and New Zealand, have illustrated the importance of culturo-linguistic congruity. In Wales, the Well-being of Future Generations (Wales) Act 2015 has come to define the political and legal pursuance of well-being. A unique piece of legislation, this legally mandates all Welsh public bodies to demonstrate they are working to achieve all seven well-being goals established by the Act. Echoing the conclusions of existing research, one identified well-being objective is the promotion of Welsh culture and the Welsh language. Taking account of the current nature of Welsh language provision within the Welsh National Health Service (NHS), the purpose of this paper is to briefly assess the extent to which the Welsh NHS is in a position to facilitate the well-being objective of ensuring service users have an opportunity to utilise the Welsh language. Despite the ambitions of the legislation, it will be argued that the Welsh language is largely absent from the well-being objectives outlined by local health boards.Increasingly, it is recognised that the opportunity to engage with one’s own culture and language is beneficial for an individual’s well-being. Research among indigenous communities in North America, Australia, Scandinavia, and New Zealand, have illustrated the importance of culturo-linguistic congruity. In Wales, the Well-being of Future Generations (Wales) Act 2015 has come to define the political and legal pursuance of well-being. A unique piece of legislation, this legally mandates all Welsh public bodies to demonstrate they are working to achieve all seven well-being goals established by the Act. Echoing the conclusions of existing research, one identified well-being objective is the promotion of Welsh culture and the Welsh language. Taking account of the current nature of Welsh language provision within the Welsh National Health Service (NHS), the purpose of this paper is to briefly assess the extent to which the Welsh NHS is in a position to facilitate the well-being objective of ensuring service users have an opportunity to utilise the Welsh language. Despite the ambitions of the legislation, it will be argued that the Welsh language is largely absent from the well-being objectives outlined by local health boards
Microbial community succession in soil is mainly driven by carbon and nitrogen contents rather than phosphorus and sulphur contents
Get PDFOrganic manure is widely applied in agricultural systems to improve soil nutrient cycling and other physicochemical properties. However, the biotic and abiotic mechanisms that drive C, N, P, and S cycling following manure application are not completely understood. In this study, soil samples were collected from long-term experimental plots that had been amended with farmyard manure or mineral fertilisers since 1964. Isotope labelling with 15N, 33P, and 35S; metagenomics; and high-throughput sequencing were used to reveal the relationships between C, N, P, and S dynamics and microbial community composition and functions depending on fertilisation. A clear niche differentiation was observed between bacteria and fungi under mineral and manure regimes. A network analysis showed that long-term manure application reduced the complexity and stability of soil microbial network. Furthermore, a variation partitioning analysis based on redundancy analysis indicated that microbial community variation was mainly driven by soil Cand N contents. Dissolved organic C was the most important factor regulating microbial community structure. Soil C and N contents explained 43.5% of bacterial and 37.9% of fungal community variations. In contrast, soil P and S contents explained 29.9% of bacterial and 20.3% of fungal community variations. Long-term manure application increased the abundance of most functional genes related to C, N, P, and S cycling. This led to increased C and N cycling rates under manure application, which provided sufficient substrates for microbial growth. Partial least squares path modelling indicated that soil physicochemical properties, especially dissolved organic carbon, directly influenced C and S cycling, whereas the N and P cycles were indirectly affected by the changes in microbial community composition. These results provide a new perspective on both direct and indirect effects of organic manure and inorganic fertilisers on the soil nutrient cycling processes mediated by soil microbial community
Genomics reveals broad hybridization in deeply divergent Palearctic grass and water snakes (Natrix spp.)
Get PDFUnderstanding speciation is one of the cornerstones of biological diversity research. Currently, speciation is often understood as a continuous process of divergence that continues until genetic or other incompatibilities minimize or prevent interbreeding. The Palearctic snake genus Natrix is an ideal group to study speciation, as it comprises taxa representing distinct stages of the speciation process, ranging from widely interbreeding parapatric taxa through parapatric species with very limited gene flow in narrow hybrid zones to widely sympatric species. To understand the evolution of reproductive isolation through time, we have sequenced the genomes of all five species within this genus and two additional subspecies. We used both long-read and short-read methods to sequence and de-novo-assemble two high-quality genomes (Natrix h. helvetica, Natrix n. natrix) to their 1.7 Gb length with a contig N50 of 4.6 Mbp and 1.5 Mbp, respectively, and used these as references to assemble the remaining short-read-based genomes. Our phylogenomic analyses yielded a well-supported dated phylogeny and evidence for a surprisingly complex history of interspecific gene flow, including between widely sympatric species. Furthermore, evidence for gene flow was also found for currently allopatric species pairs. Genetic exchange among these well-defined, distinct, and several million-year-old reptile species emphasizes that speciation and maintenance of species distinctness can occur despite continued genetic exchange
Medically important snakes and snakebite envenoming in Iran
Get PDFSnakebite is a relatively common health condition in Iran with a diverse snake fauna, especially in tropical southern and mountainous western areas of the country with a plethora of snake species. The list of medically important snakes, circumstances and effects of their bite, and necessary medical care require critical appraisal and should be updated regularly. This study aims to review and map the distributions of medically important snake species of Iran, re-evaluate their taxonomy, review their venomics, describe the clinical effects of enve- noming, and discuss medical management and treatment, including the use of antivenom. Nearly 350 published articles and 26 textbooks with information on venomous and mildly venomous snake species and snakebites of Iran, were reviewed, many in Persian (Farsi) language, making them relatively inaccessible to an international readership. This has resulted in a revised updated list of Iran’s medically important snake species, with taxo- nomic revisions of some, compilation of their morphological features, remapping of their geographical distri- butions, and description of species-specific clinical effects of envenoming. Moreover, the antivenom manufactured in Iran is discussed, together with treatment protocols that have been developed for the hospital management of envenomed patients
High intensity fire accelerates accumulation of a stable carbon pool in permafrost peatlands under climate warming
Get PDFPeatland carbon pools store one-third of global soil carbon, but are increasingly threatened by wildfires, particularly high intensity wildfires, as a consequence of climate warming. However, with only a limited understanding of fire history reconstruction available, the long-term impacts of fire intensity on the stability of the peatland carbon pool remains poorly understood. Here, based on Fourier transform infrared spectroscopy and chemical analysis of PyC and organic matter in Hongtu (HT) peat core in the northern Great Khingan Mountains (China), historical fire intensity and fuel sources during the last 700 years were reconstructed and their effects on carbon stability evaluated. Our results showed that the major stable carbon pool (i.e. aromatics) and the retained labile carbon pool (i.e. iron-bound organic carbon, Fe-OC) in HT peatland are 278.1 ± 6.2 mg·g−1 and 6.78 ± 3.85 mg·g−1, respectively. High-intensity herb fires in peatlands occurred more easily under wet conditions and caused more PyC accumulation than shrub fires. Both climate warming and high-intensity fire promoted more aromatics and Fe-OC accumulation, increasing the overall stability of peatland carbon pool. High-intensity fire under warm climate conditions resulted in Fe-OC accumulation rates threefold higher (ca. 0.02 mg·cm−2 yr−1 to ca. 0.06 mg·cm−2 yr−1) but had no marked effects on the aromatic and PyC accumulation rates. Overall, our results suggest that high-intensity fires can accelerate stable carbon pool accumulation in peatlands during climate warming
CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence
Get PDFAbnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER2− breast cancer. We demonstrate that CDK4/6-inhibited cells overgrow during G0/G1, causing p38/p53/p21-dependent cell cycle withdrawal. Cell cycle withdrawal is triggered by biphasic p21 induction. The first p21 wave is caused by osmotic stress, leading to p38- and size-dependent accumulation of p21. CDK4/6 inhibitor washout results in some cells entering S-phase. Overgrown cells experience replication stress, resulting in a second p21 wave that promotes cell cycle withdrawal from G2 or the subsequent G1. We propose that the levels of p21 integrate signals from overgrowth-triggered stresses to determine cell fate. This model explains how hypertrophy can drive senescence and why CDK4/6 inhibitors have long-lasting effects in patients