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Pathways to suicide among police in Rajasthan: perceptions and experiences of police personnel
Get PDFBackground: Evidence regarding the experience and perceptions of police personnel with suicide in South Asia is limited. This study explored the lived experiences and perceptions of su-icide among police personnel in an Indian state. The focus was on explanations of and reasons for suicide. Methods: We conducted 20 qualitative interviews in 2021 with police of different ranks, guided by a topic guide. The reflexive thematic analysis approach was supported by the use of NVivo 12, a qualitative software package. Results: We explore three intersecting key themes around suicide in the police force, including: (1) the stressful police environment; (2) expectations of mental strength; and (3) police image and help-seeking. We discuss the tensions between these themes and how to address the challenges of supporting police personnel. Conclusion: To support and improve police personnel’s mental well-being training and support are needed but also broader changes at the organisational level. These need to take social and historical factors into account. An increased level of suicide and mental health literacy will not only benefit the police force but also the general public, and it would be very timely with recent changes in the Indian mental health and suicide policy context
Route of Change on Angleysey
Get PDFA research collaboration between the Bodorgan Estate, in the south-west of Anglesey, and the Institute for the Study of Welsh Estates (ISWE) at Bangor University, is shedding light on how the estate was put to a variety of usesduring and after the Second World War
The Rotting City : Surrealist Arts of Noticing the Urban Anthropocene
Get PDFThis article develops a surrealist approach to researching and writing about the urban Anthropocene, as a critical contribution to existing literatures on “arts of noticing” and “staying with the trouble.” Drawing on psychogeographical explorations of the city of Iquitos in the Peruvian Amazon and distancing itself from conventional modes of academic writing, the article presents a montage of surrealist images of this (post)apocalyptic metropolis. Iquitos emerges as a palimpsest of the wreckage of repeated resource booms, strewn with the ruins of a stillborn modernity and incubating an uncanny fusion of apocalyptic and utopian elements observable in the everyday practices of its subaltern inhabitants. Just as Paris was the capital of the 19th century for Walter Benjamin’s Arcades Project, so the interpretation of Iquitos as an extreme metaphor for our combined and uneven apocalypse designates it as the capital of the Anthropocene
Crafting a collaborative Public Services Board culture: A policy briefing for Public Services Boards
Get PDFCosts of orphan medicinal products: longitudinal analysis of expenditure in Wales
Get PDFBackground: The Orphan Regulation ((EC) No 141/2000) has successfully redirected private and public investment towards previously neglected areas through incentives, regulatory obligations and rewards. However, the growth inthe number of licensed orphan medicinal products (OMPs) has led to concerns about increased costs. The aims were to investigate the trend in the costs of OMPs to the National Health Service in Wales, to attribute costs of medicineswithin and outside periods of marketing exclusivity, and estimate the contribution of individual medicines to the overall costs of OMPs.Methods: Expenditure on OMPs in Wales was analysed between the 2014/15 and 2019/20 financial years using data on prescriptions dispensed in primary care, secondary care, and specialised commissioned services. OMP spend wascalculated as a proportion of total medicines expenditure, whether it was incurred during, or outside the marketing exclusivity period (MEP), and by therapeutic area and medicine.Results: Overall spend on OMPs and all medicines increased from £32 m to £82 m, and from £1,030 m to £1,198 m, respectively, with the proportion of spend on OMPs more than doubling from 3.1% to 6.9% per annum. Average year-on-year growth in the costs of OMPs was 21%, compared to 2% for other medicines. Costs following MEP expiry contributed significantly to overall OMP costs, increasing from £8 m to £30 m, corresponding to an increase from 24%to 37%. Treatments for ‘malignant disease and immunosuppression’, ‘nutrition and blood’ and the ‘respiratory system’ accounted for 90% of all OMP spend. Half of total OMP annual expenditure was on just 4 medicines in 2014/15,increasing to 8 in 2019/20.Conclusions: Both the number of OMPs and the amount spent on OMPs in Wales has increased over time, possibly as a consequence of favourable licensing conditions, permissive health technology assessment policies and dedicatedfunding.<br/
Women’s experiences of social support during pregnancy: a qualitative systematic review
Get PDFBackgroundSocial support during pregnancy can alleviate emotional and physical pressures, improving the well-being of mother and child. Understanding women's lived experiences and perceptions of social support during pregnancy is imperative to better support women. This systematic review explores and synthesises the qualitative research on women's experiences of social support during pregnancy.MethodsDatabases PubMed, CINAHL, MEDLINE, APA PsycInfo and Scopus were searched with no year limit. Eligible studies included pregnant women or women who were up to one year postpartum and were assessed on their experiences of social support during pregnancy. The data were synthesised using the thematic synthesis approach.ResultsFourteen studies were included with data from 571 participating women across ten countries; two studies used focus groups, and 12 used interviews to collect their data. Four main themes were developed ('a variety of emotional support', 'tangible and intangible instrumental support', 'traditional rituals and spiritual support', and 'the all-encompassing natal home'), and six sub-themes ('female network connections', 'care and affection from the husband', 'dissatisfaction with relationships', 'financial support from the husband and family', 'practical support from family and friends', 'health information support').ConclusionsThis systematic review sheds light on women’s experiences of social support during pregnancy. The results indicate a broad variety of emotional support experienced and valued by pregnant women from different sources. Additionally, women expressed satisfaction and dissatisfaction with tangible and intangible support forms. It was also highlighted that spirituality played an essential role in reducing stress and offering coping mechanisms for some, whereas spirituality increased stress levels for others
Challenger Society for Marine Science: Increasing Opportunity Through an Equity, Diversity, Inclusivity, and Accessibility Working Group
Get PDFThe Challenger Society for Marine Science (CSMS) is the learned society for marine scientists based in the United Kingdom, with a membership of over 470 people from >100 institutions, across all academic career stages. Members of the CSMS have been interested in improving the representation of a diverse range of identities in UK marine science, largely driven by their own experiences of inequity in the discipline, such as the challenges faced by women (Hendry et al., 2020). The structural exclusion of individuals by race, sex, ethnicity, social class, disability, sexuality, and the compound sum of these factors can result in a lack of diversity during recruitment and poor retention. Since 2021, CSMS has formed the first UK-wide equity, diversity, inclusion, and accessibility (EDIA) working group for marine scientists, with the aim of coordinating action to address the causes of exclusion and to improve representation across the discipline. The group of 25 volunteers meets each month to discuss a topical agenda, and the chair of the working group sits on the council of CSMS, providing EDIA input from the working group on society-wide strategic decisions
Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases
Get PDFFluorine forms the strongest single bond to carbon with the highest bond dissociation energy among natural products. However, fluoroacetate dehalogenases (FADs) have been shown to hydrolyze this bond in fluoroacetate under mild reaction conditions. Furthermore, two recent studies demonstrated that the FAD RPA1163 from Rhodopseudomonas palustris can also accept bulkier substrates. In this study, we explored the substrate promiscuity of microbial FADs and their ability to defluorinate polyfluorinated organic acids. Enzymatic screening of eight purified dehalogenases with reported fluoroacetate defluorination activity revealed significant hydrolytic activity against difluoroacetate in three proteins. Product analysis using liquid chromatography-mass spectrometry identified glyoxylic acid as the final product of enzymatic DFA defluorination. The crystal structures of DAR3835 from Dechloromonas aromatica and NOS0089 from Nostoc sp. were determined in the apo-state along with the DAR3835 H274N glycolyl intermediate. Structure-based site-directed mutagenesis of DAR3835 demonstrated a key role for the catalytic triad and other active site residues in the defluorination of both fluoroacetate and difluoroacetate. Computational analysis of the dimer structures of DAR3835, NOS0089, and RPA1163 indicated the presence of one substrate access tunnel in each protomer. Moreover, protein-ligand docking simulations suggested similar catalytic mechanisms for the defluorination of both fluoroacetate and difluoroacetate, with difluoroacetate being defluorinated via two consecutive defluorination reactions producing glyoxylate as the final product. Thus, our findings provide molecular insights into substrate promiscuity and catalytic mechanism of FADs, which are promising biocatalysts for applications in synthetic chemistry and bioremediation of fluorochemicals
The unprecedented 2022 extreme summer heatwaves increased harmful cyanobacteria blooms
Get PDFHeatwaves are increasing and expected to intensify in coming decades with global warming. However, direct evidence and knowledge of the mechanisms of the effects of heatwaves on harmful cyanobacteria blooms are limited and unclear. In 2022, we measured chlorophyll-a (Chla) at 20-s intervals based on a novel ground-based proximal sensing system (GBPSs) in the shallow eutrophic Lake Taihu and combined in situ Chla measurements with meteorological data to explore the impacts of heatwaves on cyanobacterial blooms and the potential relevant mechanisms. We found that three unprecedented summer heatwaves (July 4-15, July 22-August 16, and August 18-23) lasting a total of 44 days were observed with average maximum air temperatures (MATs) of 38.1 ± 1.9 °C, 38.7 ± 1.9 °C, and 40.2 ± 2.1 °C, respectively, and that these heatwaves were characterized by high air temperature, strong PAR, low wind speed and rainfall. The daily Chla significantly increased with increasing MAT and photosynthetically active radiation (PAR) and decreasing wind speed, revealing a clear promotion effect on harmful cyanobacteria blooms from the heatwaves. Moreover, the combined effects of high temperature, strong PAR and low wind, enhanced the stability of the water column, the light availability and the phosphorus release from the sediment which ultimately boosted cyanobacteria blooms. The projected increase in heatwave occurrence under future climate change underscores the urgency of reducing nutrient input to eutrophic lakes to combat cyanobacteria growth and of improving early warning systems to ensure secure water management.</p