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Immigrant mothers’ intersectional invisibility and hypervisibility in Helsinki’s diverse neighbourhoods
No full textDigiKunto - Kuntoutuksen ammattihenkilöiden kokemukset asiakas- ja potilastietojärjestelmistä ja digitaalisista palveluista työn tukena 2025 : Tutkimushankkeen loppuraportti
No full textDigitalisaatio muuttaa kuntoutusalan arkea Miten tietojärjestelmät tukevat kuntoutuksen ammattihenkilöiden työtä? DigiKunto-hankkeessa tutkittiin ensimmäistä kertaa valtakunnallisesti kuntoutuksen ammattihenkilöiden kokemuksia asiakas- ja potilastietojärjestelmistä sekä digitaalisten palveluiden käytöstä. Käyttökokemukset osoittavat, että kuntoutuksen ammattihenkilöt eivät koe järjestelmien tukevan kaikilta osin heidän työtään, eikä alan erityispiirteitä huomioida riittävästi. Kuntoutuksen ammattihenkilöt kaipaavat lisää koulutusta, tukea ja osallistumismahdollisuuksia järjestelmien kehittämiseen, jotta digitalisaatio todella tukisi vaikuttavaa ja asiakaslähtöistä kuntoutustyötä
Home in Finland, Work in Norway : The Multilocal Everyday Life of Finnish Nurses Commuting to Norway
No full text2 μm Broadband Amplification in Tapered Fiber Devices Using PbS Quantum Dots
No full textBroadband optical amplifiers operating in the 2 μm spectral region are critical for advancing mid-infrared photonic systems, yet achieving high gain with low noise remains challenging. In this work, we demonstrate a high-performance tapered fiber amplifier incorporating PbS quantum dots (QDs) as the gain medium. By optimizing the tapering geometry and QD doping concentration, we achieve a broadband on-off gain of >15 dB across a 200 nm bandwidth (1900–2100 nm). The unique combination of PbS QDs’ size-tunable bandgap and the tapered fiber’s enhanced evanescent field interaction enables efficient pump-probe overlap, resulting in a broader gain bandwidth compared to conventional rare-earth-doped fiber amplifiers. This work establishes a promising platform for compact, high-bandwidth mid-infrared light sources and amplifiers
Pondering the non-return of ageing migrants in the Finnish-Russian everyday transnational context
No full textIn the Finnish–Russian migratory context, return migration does not exist as such. In this article, we examine the non-return migration of Russian-speaking elderly migrants through the lens of the transnational everyday. The transnational everyday of Russians in Finland has, until recently, enabled their back-and-forth trips from Finland to Russia. The combination of Finnish and Russian migratory regimes, welfare policies, closeness of places of birth and dwelling, as well as the constantly changing and tightening geopolitical situation can be seen as explanations for the almost non-existent return migration. This article also questions the concept of the ‘host’ and the ‘home’ society and explains that, in everyday transnational reality, which is lived ‘in between’ the ‘host’ and the ‘home’ concepts do not meet the lived experience of immigrants. The article is based on our long-term ethnographic work on immigration in the Finnish province North Karelia since the beginning of the 2000s. We have used ethnographic data (interviews, observations, ethnographic and autoethnographic notes) accumulated during our long-term studies in the Finnish–Russian border area. We are committed to a transnational multisited methodology. Additionally, our view is situated in border and everyday ethnography and in narrative ethnography. As a result of the study, we conclude that the contemporary geopolitical situation with the closure of the border in 2023 forces elderly Russian-speaking immigrants to become immobile, or at least diminish their travels to Russia. The everyday transnational ties of Russian speakers in Finland are now possible only in virtual forms or through laborious and expensive back-and-forth trips through Estonia, Norway, Turkey or some other third countries. This situation has tied elderly Russian speakers even more closely to Finnish society and its welfare system. The closure of the border has affected social ties of ageing Russian immigrants in different ways: Some are keen to keep up social relations despite political disagreement, but some social relations have, however, severed
New players from the old chalcone scaffold: Synthesis, identification, and characterization of new potent ABCG2 inhibitors
No full textThe ABCG2 transporter is an efflux pump that can transport various anticancer drugs and is strongly associated with multidrug resistance (MDR) in cancer. A promising strategy to combat MDR mediated by this transporter is through functional inhibition. However, there are currently no potent selective ABCG2 inhibitors in clinical trials. Chalcone, a privileged scaffold, can be easily synthesized to produce a wide array of derivatives with diverse biological applications. Notably, chalcone derivatives have been identified as inhibitors of ABC transporters, including ABCG2. In this study, we synthesized and evaluated a series of twenty chalcone derivatives as potential ABCG2 inhibitors. Out of these, ten compounds were found to completely inhibit ABCG2 transport activity. Among them, compounds 10, 19, and 20 demonstrated particularly high potency, with EC50 values (compound concentrations giving a half-maximal inhibition) of 0.34, 0.83, and 0.94 μM, respectively. These three promising chalcone derivatives selectively inhibited ABCG2, enhanced the binding of the 5D3 conformational antibody, and exhibited low cytotoxicity, with estimated IG50 values (compound concentrations giving a half-maximal cell viability) exceeding 50 μM. The therapeutic ratio (TR), calculated as the ratio of IG50 to EC50 values, revealed that 10 had a TR greater than 147, nearly 3-fold higher than those of 19 (greater than 60) and 20 (greater than 53). Modeling studies, while biased towards the conformation of the selected starting compound, successfully reproduced relevant interactions with residues Phe439 and Asn436, which are consistent with ABCG2 inhibition. Finally, 10 was shown to chemosensitize cell lines that overexpress ABCG2, effectively overcoming the MDR phenotype mediated by this transporter