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The role of cardiovascular multimodality imaging in the evaluation of Anderson-Fabry disease: from early diagnosis to therapy monitoring A clinical consensus statement of the ESC Working Group on Myocardial and Pericardial Diseases and the European Association of Cardiovascular Imaging of the ESC
No full textAnderson–Fabry disease (AFD) is a rare genetic disease with X-linked transmission characterized by a defect in the enzyme alpha-galactosidase A, which impairs glycosphingolipid metabolism and leads to an excessive storage of globotriaosylceramide (Gb3) within lysosomes. AFD involves renal, cardiac, vascular, and nervous systems and is mainly observed in male patients with onset in childhood, although cardiac manifestation is often shown in adults. AFD cardiomyopathy is caused by the accumulation of Gb3 within myocytes first showed by left ventricular hypertrophy and diastolic dysfunction, leading to restrictive cardiomyopathy and systolic heart failure with biventricular involvement. The diagnosis of AFD cardiomyopathy may be insidious in the first stages and requires accurate differential diagnosis with other cardiomyopathies with hypertrophic phenotype. However, it is fundamental to promptly initiate specific therapies that have shown promising results, particularly for early treatment. A careful integration between clinical evaluation, genetic tests, and cardiac imaging is required to diagnose AFD with cardiac involvement. Basic and advanced echocardiography, cardiac magnetic resonance, and nuclear imaging may offer pivotal information for early diagnosis (Graphical Abstract), and the management of these patients is often limited to centres with high expertise in the field. This clinical consensus statement, developed by experts from the European Society of Cardiology (ESC) Working Group on Myocardial and Pericardial Diseases and the European Association of Cardiovascular Imaging of the ESC, aims to provide practical advice for all clinicians regarding the use of multimodality imaging to simplify the diagnostic evaluation, prognostic stratification, and management of cardiac involvement in AFD
”Tortillat, kaverit, oppiminen” : Ensimmäisen luokan oppilaiden kuvauksia koulumotivaatiostaan sekä opettajasta sen tukijana
No full textPromises made to reduce health inequalities in the Finnish government programs 1991-2023
No full textAssessing the role of short-chain chlorinated paraffins in the toxicity of ambient particulate matter
No full textShort-chain chlorinated paraffins (SCCPs) are widespread in atmospheric particulate matter (PM), but their toxicological contribution when adsorbed onto PM remains unclear. Using a respiratory A549/THP-1 co-culture cell model, we evaluated the effects of low-dose SCCPs (based on levels in real environment) combined with carbon particles (60 nm). Carbon particles significantly impaired cellular metabolic activity and induced oxidative stress, whereas SCCPs alone at low doses had minimal cytotoxic or oxidative effects. Co-exposure to SCCPs and carbon particles did not consistently exacerbate toxicity compared to carbon particles alone, and in some cases, even attenuated specific effects. Inflammatory cytokine expression revealed a general dose-dependent suppression, particularly in co-exposure groups, with IL-8 and TNF-α levels significantly reduced. Cell cycle alterations were minor across all groups, though subtle shifts in DNA replication phases were observed. Toxic potency evaluation showed that carbon particles combined with high-dose SCCPs (Maoming-equivalent) had slightly greater overall toxicity (0.228) than carbon particles alone (0.220) or low-dose SCCPs (Guangzhou-equivalent, 0.211), indicating a potential threshold effect for SCCP contribution at low environmental levels. This study highlights the complex and non-linear interactions between SCCPs and PM in terms of cellular toxicity and emphasizes the importance of considering environmentally relevant co-exposure scenarios in health risk assessments
Varhaiskasvatuksen opettajaopiskelijan opetusharjoittelun pedagoginen yhteisöohjaus päiväkodin työyhteisössä
No full text
Non-destructive assessment of tissue properties using Near Infrared (NIR) Spectroscopy from culture medium
No full textDen finska Sagrada Familia – varför tog det 150 år att bygga en regionförvaltning?
No full textDet dröjde ytterligare 100 år innan välfärdsområdena kunde ta över social- och hälsovårdstjänsterna samt räddningsväsendet. I och med reformen av social- och hälsovårdssystemet (SOTE) har Finland övergått till en tredelad offentlig förvaltning. I denna artikel undersöks varför försöken att skapa landskapsförvaltning före den nuvarande reformen har misslyckats. Samtidigt undersöks alternativa modeller genom vilka lagstiftaren har försökt kringgå lösningarna för inrättandet av lokala självstyrelseorgan.
Tillvägagångssättet är rättshistoriskt men studien är också ett bidrag till den aktuella rättsdebatten i Finland. Studiens källor är för ämnet relevanta originaldokument (t.ex. riksdags- och andra lagberedningsdokument, juridisk litteratur från olika perioder) samt forskningslitteratur
