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Special education teachers’ perceptions of the inclusion in the early childhood education
No full textComparison of Starrsed RS instrument and Westergren method in the determination of erythrocyte sedimentation rate
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Nursing students’ experiences of inappropriate treatment and violence in clinical placements
No full textIntracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse
No full textPathological tau accumulation disrupts neuronal function, leading to neurodegeneration and dementia in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Despite the progression of several anti-tau therapies to clinical trials, no disease-modifying treatments for tauopathies exist. Tau hyperphosphorylation is a key factor in pathology progression. Among all tau phosphorylation sites targeted in preclinical passive immunization studies, the classic AT8 pathological tau phosphorylation sites have remained understudied. Thus, we investigated the potential of immunotherapy against phosphorylated tau (pTau) in a P301S mouse model of tauopathy. We administered a new monoclonal B6 antibody that targets tau phosphorylation sites at serine 202, threonine 205 and serine 208 either systemically for 3 months or locally into the cerebral ventricles for 1 or 2 months via an osmotic minipump. Systemic administration failed to reach the brain effectively, and subsequently, was not able to alleviate the progressive motor impairment seen in this tauopathy mouse model. By contrast, intraventricular administration improved motor function in earlier stages of pathology but had a lesser effect in later stages. The local administration for 8 weeks reduced the number of pTau positive neurons in cortex and hippocampus. Our findings indicate that targeting the classical pathological tau phosphorylation sites can ameliorate tau pathology and improve function in a mouse tauopathy model. These results add to growing evidence supporting the efforts in developing tau-targeting immunotherapies for neurodegenerative diseases associated with pathological tau deposits
Moral orders of innovation
No full textThe entry examines the role of normative expectations in fostering innovation, which is conceptualized as a collaborative endeavour among industrial sectors, scientists and governments. These stakeholders establish policies designed to stimulate innovation, which may originate from self-interest or a desire to benefit society. Innovations are linked to a network of rights and duties, which may be referred to as ‘moral orders of innovation’ by applying the vocabulary used by social scientist Rom Harré. This entry presents a comprehensive account of moral orders and their relationship to innovation and proposes a moral-order-based approach to innovation management research. Furthermore, the chapter examines the recent prominence of science diplomacy and its conceptualization of science as a tool for societal advancement, offering insights into the impact of innovation on national and international practices
Catching the (next) wave: Accelerating digital literacy professional development of in-service English language teachers at Finnish university language centres
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