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Transfer of sediment-derived carbon into blackworm and crucian carp for 14C biosphere assessment
No full textThe time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force
No full textThe European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries. Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia, a large proportion of them do not have access to this treatment. Concerns about clozapine-induced agranulocytosis and stringent blood monitoring rules are major barriers to clozapine prescribing and use. There is a growing body of evidence that the incidence of clozapine-induced agranulocytosis is very low after the first year of treatment. Maintaining lifelong monthly blood monitoring after this period contributes to unjustified discontinuation of clozapine. We leverage recent and replicated evidence on the long-term safety of clozapine to call for the revision and updating of the EMA’s blood monitoring rules, thus aiming to overcome this major barrier to clozapine prescribing and use. We believe the time has come for relaxing the rules without increasing the risks for people using clozapine in Europe
Data supplementing the paper "Digital twins enable full-reference quality assessment of photoacoustic image reconstructions"
No full textThis data repository accompanies the paper, which introduces a digital twinframework to enable full-reference image quality assessment (IQA) in photoacoustic tomography. In conventional experiments, quantitative comparison of reconstruction algorithms is challenging because no-reference IQA measures are often inadequate, and full-reference measures require a known ideal reference image (which is unavailable for real tissue or physical phantoms). The paper’s approach overcomes this by using numerical tissue-mimicking phantoms and a model of the imaging system as a digital twin of the experiment. By calibrating the simulations to match experimental data, the authors create a reference object that is close to a “ground truth” and corresponding simulated sensor data that mimic the real experiment, thus reducing the simulation-experiment gap. Using this digital twin, the paper quantitatively compares multiple state-of-the-art image reconstruction algorithms for photoacoustic imaging. Among these is a fast Fourier transform-based reconstruction algorithm for circular detection geometries, which is tested on experimental data for the first time. The results demonstrate that the digital phantom twin approach enables rigorous, full-reference IQA of reconstructions: for example, the Fourier algorithm achieved image quality comparable to iterative time reversal but at significantly lower computational cost. This highlights the utility of the digital twin framework for assessing reconstruction accuracy and the fidelity of the forward model, facilitating fair comparisons of different algorithms. If you use this code or data in your research, please cite the corresponding paper. Janek Gröhl, Leonid Kunyansky, Jenni Poimala, Thomas R. Else, Francesca Di Cecio, Sarah E. Bohndiek, Ben T. Cox, and Andreas Hauptmann,“Digital twins enable full-reference quality assessment of photoacoustic image reconstructions”Journal of the Acoustical Society of America 2025
Diffuse reflectance spectra for titanium dioxide, graphitic carbon nitride, and their composites
No full textDiffuse reflectance spectra for titanium dioxide (TiO2), graphitic carbon nitride (g-C3N4), and their composites annealed at 200 and 300 oC. Bulk graphitic carbon nitride was prepared by polymerizing pure urea at 600 oC. Sol of TiO2 nanoparticles was annealed at 200 and 300 oC. Composites of TiO2 with g-C3N4 were prepared by adding urea to the TiO2 sol, lyophilizing the resulting mixture, and then annealing it at 200 and 300 oC
”Mietitään yhdessä lasten kanssa mitä ulkona tehtäisiin”: Tapaustutkimus lasten osallisuudesta ulkoilun pedagogisessa suunnittelussa
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