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Potilaan itsemääräämisoikeus ja terveydenhuollon ammattilaisten velvollisuudet: Ylimpien laillisuusvalvojien ratkaisukäytäntöjen valossa
No full textComparative Study on the Impact of Digital vs. Traditional Communication on B2B Sales Team Leadership Motivation
No full textCo-creation in private and public sector contexts
No full textCo-creation is a process where organisations and stakeholders collaborate to generate social and economic value through active participation. It empowers stakeholders by giving them a voice in shaping products, services, policies, and processes that directly affect their lives. Co-creation fosters innovation by bringing diverse perspectives together to achieve outcomes that are socially accepted and mutually beneficial. The concept has been applied across various sectors, including private, public, nonprofit, and nongovernmental organisations. In the private sector, two major research streams focus on marketing-driven value creation and crowdsourcing for innovation, highlighting how businesses and customers co-create products and services that better meet consumer needs. In the public sector, co-creation emphasises the collaboration between governments, citizens, and community groups in developing public services and policies
Impact of the information management of EU´s Common Agricultural Policy on energy efficiency in agriculture
No full textThe self-management of home care teams and related support – a home care manager’s perspective
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Membrane-permeabilizing viral capsid proteins for intracellular delivery of biomolecules
No full textPhotothermal therapy with black porous silicon nanoparticles for targeted cancer treatment
No full textPost Treatment of the Urban Wastewater Effluents for Potential Water Reuse with the Focus on Removal of Microbial Contaminants
No full textThe emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review
No full textResearch on epigenetic‒environmental interactions in the development of Alzheimer's disease (AD) has accelerated rapidly in recent decades. Numerous studies have demonstrated the contribution of ambient particulate matter (PM) to the onset of AD. Emerging evidence indicates that non-coding RNAs (ncRNAs), including long non-coding RNAs, circular RNAs, and microRNAs, play a role in the pathophysiology of AD. In this review, we provide an overview of PM-altered ncRNAs in the brain, with emphasis on their potential roles in the pathogenesis of AD. These results suggest that these PM-altered ncRNAs are involved in the regulation of amyloid-beta pathology, microtubule-associated protein Tau pathology, synaptic dysfunction, damage to the blood‒brain barrier, microglial dysfunction, dysmyelination, and neuronal loss. In addition, we utilized in silico analysis to explore the biological functions of PM-altered ncRNAs in the development of AD. This review summarizes the knowns and unknowns of PM-altered ncRNAs in AD pathogenesis and discusses the current dilemma regarding PM-altered ncRNAs as promising biomarkers of AD. Altogether, this is the first thorough review of the connection between PM exposure and ncRNAs in AD pathogenesis, which may offer novel insights into the prevention, diagnosis, and treatment of AD associated with ambient PM exposure