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Overview of the Effectiveness of Different Surfactant Administration Methods - an Umbrella Review of Meta-analyses
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Living sufficiency of older adults in Finland: intergenerational practices for sustainable futures
No full textPlanetary crises compel us to critically reassess our lifestyles, values, and worldviews. Sufficiency has gained prominence in sustainability discourse, reflecting a shift from consumerist paradigms toward culturally embedded, value-driven responses to ecological challenges. This study examines sufficiency in the everyday lives of older adults and the meanings they attach to it. It explores how older generations’ life experiences might support sustainable lifestyle adoption. The research employs qualitative methodology, drawing on twelve thematic interviews analyzed through content analysis. Sufficiency emerges not as an individual choice but as a historically and culturally constructed, communal, value-oriented practice expressed through frugality, self-sufficiency, helping others, and nature connection—not primarily as conscious sustainability pursuit, but adapted to life’s realities and a source of meaning. Interviewees viewed sufficiency as part of an intergenerational value heritage and a socio-ecological worldview encompassing spatial, ethical, and temporal dimensions. By illuminating how sufficiency is lived and understood within a specific social group, this study contributes to knowledge production in socio-ecological practice. It deepens understanding of how culturally embedded values shape sustainable behavior. Furthermore, it broadens sufficiency research beyond consumption choices, policy instruments, and economic models toward a cultural and intergenerational heritage perspective
The effects of extremely low frequency magnetic fields on genotoxicity caused by environmental carcinogens
No full textMRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses
No full textMirin, a chemical inhibitor of MRE11, has been recently reported to suppress immune response triggered by mitochondrial DNA (mtDNA) breakage and release during replication stalling. We show that while Mirin reduces mitochondrial replication fork breakage in mitochondrial 3´-exonuclease MGME1 deficient cells, this effect occurs independently of MRE11. We also discovered that Mirin directly inhibits cellular immune responses, as shown by its suppression of STAT1 phosphorylation in Poly (I:C)-treated cells. Furthermore, Mirin also altered mtDNA supercoiling and accumulation of hemicatenated replication termination intermediates—hallmarks of topoisomerase dysfunction—while mitigating topological changes induced by the overexpression of mitochondrial TOP3A, including TOP3A-dependent strand breakage at the noncoding region of mtDNA. Although Mirin does not seem to inhibit TOP3A activity in vitro, our findings demonstrate its MRE11-independent effects in cells and give insight into the mechanisms of the maintenance of mtDNA integrity
