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Delayed and Misdiagnosed Endometriosis
Get PDFAim: This research investigates whether targeted education can improve the early diagnosis of endometriosis, a chronic condition affecting around 10% of women of reproductive age. Unfortunately, endometriosis is often misdiagnosed, delaying treatment, prolonging discomfort, and lowering quality of life. Healthcare practitioners\u27 knowledge gap is addressed by this study, which examines whether organized training promotes awareness and diagnostic accuracy. This research proposal evaluates an educational intervention developed to improve gynecological experts\u27 knowledge and diagnostic skills. The main research issue is whether the intervention reduces misdiagnosis and improves patient outcomes. A quasi-experimental design will examine participants\u27 knowledge and diagnosis accuracy before and after training. Methodology: Women aged 18–44 and nurse practitioners from outpatient clinics, hospitals, and community centers will participate. Structured questionnaires will assess knowledge and diagnostic skills, while chart reviews will assess accuracy. To evaluate knowledge and accuracy changes, descriptive statistics, paired t-tests, and regression will be used. Diagnostic accuracy and endometriosis knowledge among healthcare providers are predicted to improve. The research expects this intervention to drastically reduce misdiagnosis rates, improving patient outcomes and quality of life. The study concludes a specialized training program can overcome endometriosis diagnostic hurdles, emphasizing the importance of provider education in early detection and managemen
Paleoecology Perspectives for Planetary Health
No full textInsights from the field of paleoecology can be integrated into the planetary health framework to improve our understanding of global environmental change
Sustainability Orientation, Sustainability Implementation, and Brand Image in Service Firms
Get PDFThis paper uses legitimacy theory and cognitive dissonance theory to explore the relationship between sustainability orientation, sustainability implementation, and brand image in the service sector. Specifically, we examine the mediating role of implementation—the translation of strategic intent into actionable practices—on customers\u27 perceptions. Using multilevel analyses of 31 US service firms and a survey of 6891 customers, we find that sustainability implementation is a strong positive predictor of brand image. However, sustainability orientation alone has a negative direct effect on brand image, suggesting that stated commitments without corresponding action can harm perceptions. Crucially, sustainability implementation positively mediates the relationship between orientation and brand image. This research addresses a key gap in the literature by demonstrating that, in the service sector, genuine action, not just communication of intent, is essential for building a sustainable brand. From a practical standpoint, the findings highlight that strategic intent toward sustainability, while necessary, is insufficient. To avoid greenwashing perceptions, firms must couple their sustainability orientation with effective and visible implementation of environmental and social initiatives
Shadows of Discrimination: Impacts of Ambient Discrimination on Queer People in the United States
Get PDFPeople identifying as LGBTQIA2S+ in the United States experience victimization, direct discrimination, and violence at a rate of 2 to 4 times higher than their heterosexual counterparts (Bender & Lauritsen, 2021), leading to higher levels of psychological pain and suicidal ideation, with up to 50% of LGBTQIA2S+ people having suicidal thoughts in their lifetimes. Those who experience ambient discrimination, such as witnessing or being made aware of discriminatory behavior of someone other than oneself in your group, have higher levels of psychological pain, PTSD, and substance use (Peterson et al., 2019). The goal of the present study is to gain a greater understanding of how ambient discrimination affects the mental health of LGBTQIA2S+ people, and to recognize the ripple effect of continued discrimination laws as witnessed by those in states with queer-specific nondiscrimination laws. Participants in this study included 20 LGBTQIA2S+ identifying adults who live in states with queer-specific nondiscrimination laws in the United States. Participants will complete a survey including an adapted version of the Daily Heterosexist Experiences Questionnaire (Balsam et al., 2013) as well as the Depression Anxiety Stress Scale- 21 (Lovibond & Lovibond, 1995). This study has found a strong positive Pearson R correlation between levels of ambient discrimination and levels of anxiety and psychological stress, while finding a weak positive correlation with ambient discrimination and depression. This study is important because no research has yet examined the effects of ambient discrimination with regard to state queer-specific nondiscrimination laws, thus advancing the understanding of how political and societal changes shape LGBTQIA2S+ people\u27s psychological well-being. In sum, this study acts as a foundation for future research on the interconnectedness of legal, personal, and ambient discrimination
Developing a Culturally Sensitive Nursing Framework for Muslim Patients Practicing Ramadan: Focusing on Fasting Benefits and Islamic Dietary Recommendations
Get PDFBackground: Muslims practice Ramadan, a month-long period of fasting from dawn to dusk, yet many healthcare providers lack knowledge of its principles and practices. Hospitals lack formal education on caring for fasting Muslim patients, leading to a knowledge deficit in cultural competence and sensitivity of Islamic practices. Purpose: This paper proposes a research design for a nurse education program on Ramadan fasting to promote cultural competence and sensitivity in nursing care. The proposed research aims to educate nurses on Islamic practices, particularly Ramadan, to bridge the cultural competency gap. The literature review also explores the health benefits of fasting and Islamic dietary guidelines. Method: A quantitative quasi-experimental pre-test and post-test survey design will be used, with approximately 50-75 licensed registered nurses. Participants must be actively employed with a minimum of one year of work experience in various specialty areas related to direct and indirect patient care. They will be randomly selected from hospitals within a large healthcare network in the Bay Area. A confidential electronic survey will determine their demographics and understanding regarding Ramadan fasting and Islamic dietary guidelines using a Likert scale. Results: The collected data will be used to gauge competence levels before and after the education intervention. The findings of the research study will offer insight into the understanding and knowledge gaps of nurses regarding healthcare of fasting Muslim patients. Conclusion: Implementing a culturally competent nursing framework on Ramadan fasting and Islamic dietary guidelines is relevant to nursing care as it enhances knowledge on diverse patient populations. This research proposal will contribute to positive patient health outcomes and increased patient satisfaction.https://scholar.dominican.edu/nursing-student-research-posters/1170/thumbnail.jp
Profiling Brain Biodistribution and Spatial Transcriptomics of Antisense Oligonucleotides
No full textAntisense oligonucleotides (ASOs) are short, single-stranded RNA molecules that can be used to treat genetic disorders. They operate by binding to complementary mRNA nucleotide sequences, triggering mechanisms that can decrease, increase, or otherwise alter protein expression. Although ASOs are emerging as a prominent area for drug development due to this targeted approach, an understanding of their delivery and effects on tissues, especially the central nervous system (CNS) remains rather limited. In some cases, an antibody to detect ASOs has been used, but since it is not commercially available, other in situ detection methods are needed. Herein, this study aimed to build a toolbox of advanced histological techniques to detect ASOs and observe their effects in the CNS. Firstly, we employed chromogenic singleplex and immunofluorescent multiplex in situ hybridization (ISH) methods to characterize the biodistribution and cellular uptake of ASOs. However, given the limitations of traditional ISH methods whereby we can image up to 4 or 5 markers before hitting the limits of spectral overlap and effective separation of fluorescent channels, we leveraged spatial transcriptomics ability to visualize up to 1000 markers as superior alternative. This enabled us to analyze and investigate the biodistribution of ASOs in the CNS along with its impact within specific cell types. Ultimately, we have developed a sophisticated analytical spatial biological toolkit to assess ASO biodistribution with defined cell populations, measure the levels of RNA following treatment, and assess overall transcriptomic changes across almost 50 different cell types within the brain. This analysis pipeline will allow for the detailed characterization and comparison of ASOs across large-scale screening efforts, improving the likelihood of a successful ASO drug development
Perspectivism and Wicked Problems: Patterns in the Discovery Process of Leibniz, Bohr, and Turing
Get PDFThis research investigates fundamental patterns in how transformative scientific knowledge emerges and becomes established, examining three pivotal cases: Leibniz\u27s development of calculus, Bohr\u27s formulation of complementarity, and Turing\u27s conceptualisation of computation and artificial intelligence. The study introduces the o-é-c model (Ouverture Ontologique - Épistémè Socialisante - Connaissance Éclairante) to explain how individual insights become integrated into collective knowledge through structured phases of development. Drawing on Minsky\u27s conception of knowledge as mental models for problem-solving and Longino\u27s social epistemology, the research demonstrates how wicked problems—those that resist formulation within existing frameworks—catalyse the creation of new knowledge domains. The model reveals how transformative frameworks emerge through three distinct phases: initial conceptual breakthrough, social validation and refinement, and systematic integration into established knowledge. Analysis of the historical cases reveals remarkable consistency in how new knowledge frameworks develop, despite vast differences in field and context. Each case demonstrates how periods of social upheaval created conditions conducive to fundamental reconceptualisation, how specific mechanisms of social validation shaped the development of new ideas, and how pedagogical tools proved crucial for knowledge transmission. The thesis makes several original contributions to philosophy of science: it bridges the gap between individual and social accounts of knowledge creation, provides specific mechanisms for how revolutionary insights become established knowledge, and demonstrates the crucial role of pedagogical development in knowledge transmission. The model helps resolve traditional tensions between revolutionary and evolutionary accounts of scientific progress while offering practical insights for addressing contemporary challenges in knowledge creation
The Impact of Workplace Stressors on Anxiety Levels and Mental Health Among Pediatric Intensive Care Nurses
Get PDFBackground: Pediatric Intensive Care Unit (PICU) nurses work in a high-stress environment where they are exposed daily to traumatic situations. The demanding emotional and physical challenges contribute to significant psychological burdens, including increased stress and anxiety. Purpose: The current paper proposes a research design to examine the outcomes of stress, anxiety levels, and mental well-being on PICU nurses when workplace support and structured debriefing sessions take place following a traumatic event. Methods: Participants will be recruited from PICU hospitals in Northern California. Participation will be voluntary, and informed consent will be obtained prior to the study. The selection criteria will include registered nurses with a minimum of three years of experience in the PICU setting. Results: Standardized mental health assessment scales, such the Generalized Anxiety Disorder-7 (GAD-7), Perceived Stress Scale (PSS), and the Depression, Anxiety, and Stress Scale will be used to gather quantitative data as well as descriptive statistics which will provide an overview of baseline psychological variables. Afterwards, inferential statistics such as the t-test will be used to compare the averages between the control group and the intervention group, utilizing pre- and post-test measures. The analysis will then examine correlations between the participation in structured debriefing following a critical incident and the improvements in psychological outcomes, including reduced anxiety levels, decreased stress, and improved psychological well-being among PICU nurses. Conclusion: Workplace stressors significantly impact the emotional health of PICU nurses and can result in heightened levels of stress and anxiety. By addressing the foundation of these challenges, this study recognizes the importance of mental health interventions as it supports the development of strategies to strengthen overall well-being of pediatric nurses working in critical care settings
Reassessing Pet Allergy Prevention in Children Through Early Pet Exposure in Toddlerhood
Get PDFBackground: Allergies are among children\u27s most common health issues growing up, impacting them daily and into adulthood. Among these allergies, pet allergies have become increasingly common with children around the globe developing sensitization to common household pets such as cats and dogs. Several factors cause pet allergies, including proteins found in an animal\u27s skin, saliva, urine, and dander, which are the most problematic due to their ability to remain airborne for a prolonged period. Objective: To examine the relationship between early exposure to pets during toddlerhood versus later exposure at school age and the development of pet allergies. By studying the effects of early pet exposure, we can have more precise insights into whether growing up with a pet in the household plays a crucial role in reducing the development of pet allergies. Method: To accomplish the purpose of this study, researchers will use a mixed method, quantitative and qualitative, prospective cohort study design to investigate the effectiveness of early pet exposure in toddlers in reducing the development of pet allergies. Results: The data for this study have not been collected yet, but the expected results are that children who have pets during toddlerhood will have less incidence of pet allergies and allergy symptoms than children who are introduced to pets during school age or beyond. Conclusion: Reconsidering previous studies on early pet exposure therapy can provide a modern perspective on treating allergies through exposure therapy while closing the gap in knowledge about the relationship between the immune system and pet allergens. Understanding the potential protective benefits of early pet exposure could lead to strategies that mitigate pet allergies, enhancing children\u27s long-term health and quality of life
The Role of Sexual Assault Nurse Examiners: Addressing the Shortage and Its Implications for Healthcare
Get PDFBackground: Sexual Assault Nurse Examiners (SANE) are registered nurses specifically trained to perform forensic examinations and provide medical and emotional support to sexual assault victims. Many nursing programs lack formal education on SANE practices, which can hinder students\u27 preparedness to address such cases in their future careers.
Method: A mixed-methods, three-phase approach to evaluate the effectiveness of a Sexual Assault Nurse Examiner (SANE) training module within the Dominican University of California Nursing Program. 40- 60 nursing students will be separated into two separate community health classes with one given module in SANEs nursing and the other not. Both classes will be given a pre and post to measure knowledge gained.
Data: The anticipated results of a performed paired T-test would be a mean score on the posttest was significantly higher than the mean score on the pretest (t(29) = 5.62, p \u3c 0.001). The anticipated results of an independent T-test that will be performed on the intervention group demonstrated a significantly higher mean increase in knowledge compared to the control group (t(58) = 4.78, p \u3c 0.001).
Conclusion: The findings confirm that the SANE training module had a positive and statistically significant effect on nursing students\u27 preparedness to handle sexual assault cases and bacground into this specific nursing field, highlighting the value of incorporating such training into nursing curriculum