6810 research outputs found
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Leveraging microgravity to model metabolic aging in human peripheral blood mononuclear cells
No full textExposure to microgravity (µG) during spaceflight or via ground-based analogs induces a physiological deterioration with features reminiscent of organismal aging but occuring at an accelerated rate. The immune system is particularly susceptible, showing parallels between aging and µG exposure, but the convergent cellular mechanisms underlying these parallel states of immune dysfunction remain poorly understood. We posit that exposure to simulated µG induces a metabolic phenotype in the immune cells that recapitulates metabolic signatures of immunosenescence. In this thesis, we compared the effects of aging, short-term (24 hours) simulated µG, and pro-inflammatory stimulation with lipopolysaccharide (LPS) on the energy metabolism of human peripheral blood mononuclear cells (PBMCs) from young (20-30 years old) and older (65+ years old) male human donors through the use of a flow cytometry-based single-cell energetic metabolism by profiling translation inhibition (SCENITH) method. These results demonstrated that chronological aging of many immune cell subsets is defined by a significant shift away from mitochondrial dependence for energy production. Daylong exposure to simulated µG induced a nearly identical metabolic phenotype in PBMCs from young donors. Metabolic states of both aged and µG-exposed PBMCs closely resembled the profile of acutely inflamed cells stimulated with LPS. These findings establish mitochondrial impairment as a hub linking the immunometabolic profiles of aging and µG exposure and suggest that the basal state of immune cells under these conditions is primed for inflammation
The Effects of Antidepressant Medications on Sleep Quality in Dominican University of California Students
No full textWe spend approximately one third of our life time sleeping or attempting to sleep. The quality of our sleep is equally, if not more important than the amount of sleep we get. This study assesses the effects that medications, specifically antidepressants, can have on sleep quality in Dominican University of California students. 118 participants completed a Qualtrics survey including questions regarding stress, sleep quality, medication lists, and demographics. This study utilized the Pittsburgh Sleep Quality Index (PSQI) to quantify participants’ sleep quality as the outcome. Participant stress levels were assessed with a Likert scale question asking for stress levels on a scale from one to six. Participants were also asked questions regarding antidepressant medications and questions regarding use of two additional groups of non-antidepressant medications. SPSS version 3.1 software was used to perform T-test, ANOVA with TukeyHSD, and linear regression. Participants who take antidepressants have worse sleep quality than those who do not take antidepressants, however, among students who reported antidepressant medication use, there is not a significant difference in sleep quality between different types of antidepressants taken. Further research that includes a larger and more diverse population size is needed to investigate how academic stressors influence antidepressant use and sleep quality
Ordinary Time
No full textThe poems explore the author’s early life and education as well as the transition from engineer to priest and from priest to poet
Investigating the expression profile of AAV and AAV retro via different CNS routes of administration
No full textAAV gene therapy uses a modified non-replicating virus to deliver genetic material into cells. This method has allowed targeted and sustained expression of genetic material for therapeutic purposes. Many AAV serotypes have been identified with varying neuronal expression profiles, yet one of the main challenges with CNS gene therapy is brain delivery and controlled distribution of AAV to relevant cells. To understand the impact of delivery route on AAV expression profile, we investigated various combinations of direct CNS injections with different AAV serotypes. Retro-orbital (RO), Intracerebral ventricle (ICV), Intrathalamic, (ITh), and Intraputamen (IPu) injections were explored using 4 different AAV capsids at varying doses in adult C57BL/6 mice. Each delivery route at 3 weeks post-injection demonstrated a distinct expression profile of the capsid injected, with IPu injections producing the most extensive and robust reporter expression, particularly within forebrain areas. Furthermore, an AAV with retrograde transport capability delivered by ITh injection labelled specific layer 5 cortical circuitry, which may be advantageous. A matrix of data mapping the role of route of administration and capsid on expression profile is reported here
Mortal in Their Holdings: A Collection of Poems
No full textHere is a slice out of a life: A Filipina American woman navigates love, future motherhood, an America that is getting harder to recognize, and the powers of family—both chosen and inherited. These poems take place across the globe and explore changing worlds and changing bodies with both searing clarity and a surreal abstraction. Using mainly free verse and rarely longer than a page, these compact poems attempt to justify the consequences of being human. Navigating the “headless orchestra” of undergoing a surgical abortion and the diabetes that plagues the author’s family as “clanking dishes on a hollow organ,” no clinical detail is spared in the verse of this nurse-turned-poet. Her language sings most when she is in love or in protest. The rally cry of this collection can be found in the wisdom passed through generations: “There is caribou taming and cannula placing and metaphor making to pass on.
Gerontological Care and Reflective Practice: Person-Centered and Caring Dimensions
No full textGerontological Care and Reflective Practice: Person-Centered and Caring Dimensions focuses on the significance of caring and humanistic approaches towards the health and wellbeing of older adults, guided by the World Health Organization\u27s broad definition of health. With an emphasis on holistic nursing and person-centered care, the text addresses a variety of interwoven themes such as diversity, equity, inclusion, health literacy, healthcare disparity, and the importance of cultural and Indigenous beliefs in healing practices. Additionally, it discusses human dignity and empathy through life\u27s transitions, including end-of-life care.
The book presents theoretical insights, including frameworks and models, and practical applications through exercises, case studies, and evidence-based tools. The instructional design is based on adult learning principles, which treat learners as autonomous individuals with unique knowledge and life experiences. The book lays out a path that guides readers from fundamental human aspects of aging to more complex concepts with a strong grounding in real-world experiences.
Gerontological Care and Reflective Practice is designed to help readers elevate the quality of life for older adults and encourages informed decision-making align with personal health goals. The book is intended for pre-licensure nursing students and can also be used by ancillary healthcare personnel, family caregivers, and community organizations servicing older adults.https://scholar.dominican.edu/faculty-authored-books/1027/thumbnail.jp
Art and Design as Tools for Memory Care Navigation and Connection Building
Full text linkMemory care environments present unique challenges for residents experiencing cognitive decline. This white paper explores the role of art-centered design and innovative UX research to develop tools that enhance navigation autonomy and foster social connections. The proposed solutions prioritize resident well-being while offering scalable frameworks for implementation across senior living communities
Comparing Human Milk-derived vs Bovine-derived Fortifiers in Formula-fed Preterm Infants on the Incidence of Necrotizing Enterocolitis
No full textNecrotizing enterocolitis (NEC) is one of the leading causes of death in infants \u3c 32 weeks gestation and/or \u3c 1500g. Human breast milk lowers NEC rates through immunologic, microbial, and gut-protective mechanisms. When maternal or donor milk is unavailable, infants require formula with fortification but the safest type of fortifiers remains unclear. Bovine-derived fortifiers may increase gut inflammation; human milk-derived fortifiers may offer more protection. Limited research exists comparing these fortifiers when infants are exclusively formula fed. Determining if human milk-derived fortifiers still reduce NEC risk could influence NICU feeding guidelines and improve outcomes.https://scholar.dominican.edu/nursing-student-research-posters/1181/thumbnail.jp
Assisting New Graduate Nurses Through Support Systems
No full texthttps://scholar.dominican.edu/nursing-student-research-posters/1186/thumbnail.jp
The Hidden Verdict: Measuring Implicit Bias in Juror Decision-Making
Full text linkThis experiment examines the influence of implicit bias awareness on juror decision-making in cases involving Hispanic defendants. Explicitly, it tests three hypotheses: (1) bias-educated jurors will demonstrate lower conviction rates for Hispanic defendants, (2) these jurors will report higher confidence in their verdicts, and (3) they will show greater awareness of how their previous experiences influence their decision-making. This experiment uses a mock jury paradigm to investigate whether bias awareness interventions affect verdict decisions and juror confidence levels in cases with Hispanic defendants. Ninety participants were randomly assigned to receive or not receive implicit bias education before reviewing a case study with a Hispanic defendant. Following verdict decisions, participants rated their confidence levels and reported whether prior experiences influenced their decision-making. The findings indicated that implicit bias instructions, given along with regularly administered ones, have a positive impact on a juror’s ability to stay objective to evidence. There were no significant findings regarding confidence or influence of previous experience. Understanding this dynamic is crucial for developing practical strategies to enhance impartiality in legal proceedings while maintaining the efficiency of the judicial process