İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
Not a member yet
1249 research outputs found
Sort by
The cervical spine
No full textThe cervical spine (CSS) is the most mobile part of the spine, consisting of seven vertebrae that connect the head and trunk. Neural therapy and manual medicine offer effective approaches to treating CSS dysfunction through targeted injections and mobilization techniques. These therapies can reduce pain, improve mobility, and normalize autonomic functions. Case studies demonstrate the effectiveness of these combined approaches in treating cervical spine disorders
Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
No full textComplex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignett
Beyond organ-specific therapies: A unified approach to multi-organ fibrosis
No full textOrgan fibrosis, characterized by excessive scarring of tissues in the liver, kidney, lung, and heart, poses a significant and growing global health challenge, resulting in considerable morbidity and mortality, with a lack of effective treatment options. Most research and drug development efforts have traditionally focused on individual organs in isolation. This review aims to provide a comprehensive perspective on multi-organ fibrosis, highlighting recent advances that clarify the complex cellular and molecular mechanisms involved in the liver, kidney, lung, and heart. It examines both common and organ-specific factors that drive fibrogenesis. Additionally, the review discusses the current and future landscape of antifibrotic therapies, including innovative approaches to developing pan-organ antifibrotic drugs. Challenges and future directions in the design of clinical trials are also addressed.Ziyan Pan and Mohammed Eslam are supported by a National Health and Medical Research Council of Australia (NHMRC) investigator and ideas grants (AAP2008983 and APP2001692).
Ziyan Pan ve Mohammed Eslam, Avustralya Ulusal Sağlık ve Tıbbi Araştırma Konseyi (NHMRC) araştırmacı ve fikir hibeleri (AAP2008983 ve APP2001692) tarafından desteklenmektedir
Long-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females
No full textThis study aims to explore the long-term endocrine and gonadal effects of chemotherapy and radiotherapy in female acute lymphoblastic leukemia (ALL) patients. A cohort study included girls diagnosed with ALL and treated between 2000 and 2020. Patients with at least 2 years elapsed since treatment completion were included. Endocrinological evalua tions included anthropometric measures and pubertal status, as well as fasting insulin, glucose, lipid levels, and hormone assessments for adrenal, and thyroid functions. Reproductive functions were evaluated based on gonadotropin, estradiol, and anti-Müllerian hormone (AMH) levels. A total of 51 female patients were included. At the time of study participa tion, the mean age was 14.7 years, and the mean time since treatment completion was 9.4 years. At least one endocrine disorder was present in 39.2% of participants, with dyslipidemia, insulin resistance, and obesity being the most common. Low AMH levels (<1.1 ng/dL) were found in 41.6%, particularly in those who underwent bone marrow transplantation. A significant positive correlation was found between the time elapsed since treatment and AMH levels (p<0.001, r=0.612), while age at diagnosis, risk group (standard, intermediate or high risk), and cranial radiotherapy showed no significant associations. A substantial proportion of ALL survivors developed endocrine complications, with ovarian reserve compro mised in over 40% of cases. Notably, this is the first cohort study to demonstrate a significant positive correlation between AMH levels and the time elapsed since treatment, suggesting a potential for gonadal recovery except in those exposed to intensive chemotherapy or transplantation.Open access funding provided by the Scientific and Tech nological Research Council of Türkiye (TÜBİTAK).
Bu çalışma, Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK) tarafından sağlanan açık erişim fonuyla desteklenmiştir.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Bu araştırma, kamu, ticari veya kar amacı gütmeyen sektörlerdeki herhangi bir fon kuruluşundan özel bir hibe almamıştır
Evaluation of muscle oxygenation by functional near-infrared spectroscopy in patients with myasthenia gravis during rest and exercise
No full textIntroduction: Myasthenia gravis (MG) is an autoimmune disease that is caused by autoantibodies targeting the neuromuscular junction. A few studies in the literature show that MG may negatively affect muscle metabolism. However, no current study investigates MG pathophysiology’s effect on muscle oxygenation. In this study, we aimed to investigate the difference in muscle oxygenation in MG disease and to evaluate its clinical Pathophysiological implications. Methods: 19 MG patients and 19 age, gender and body mass index (BMI) matched healthy controls participated in the study. Functional near-infrared spectroscopy (fNIRS) recordings were recorded from six channels over the biceps brachii muscles during the rhythmic elbow flexion-extension task. Results: It was observed that oxygenated-hemoglobin (HbO) (p = 0.008) and total hemoglobin (HbT) (p = 0.017) values during exercise were significantly lower in MG patients in the motor point of the biceps brachii muscle. In addition, at rest, deoxygenated-hemoglobin (HbR) levels were significantly lower in patients (p<0.05) in the motor point and the lateral region of the biceps brachii muscles. Additionally, a difference is observed in fNIRS values between the moderate-severe MG group and healthy controls. Also, a negative correlation was observed between exercise-state HbO and rest-state HbR values and disease severity (p<0.05). Conclusion: MG patients show deterioration in muscle oxygenation values during exercise and rest. Oxygenation values show significant differences in disease severity and negatively correlate with disease severity. Based on these findings, MG disease may affect muscle oxygenation and can be monitored by fNIRS
Holmium/thulium laser enucleation of the prostate
No full textWith the introduction of lasers into endourological practice, there has been a major paradigm shift in terms of urological interventions. Especially in the last 10 years, Holmium laser enucleation followed by Thulium laser enucleation of the prostate has become increasingly popular in the surgical treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). With low perioperative complication rates and successful postoperative outcomes, laser enucleation of the prostate (LEP) is now a globally accepted surgical approach for the surgical treatment of LUTS due to BPH. The aim of this chapter is to provide an overview of laser enucleation of the prostate; including operating theatre preparation prior to LEP, different surgical techniques, details of the learning curve, and postoperative complications
Formulation and characterization of an oleuropein-enriched oral spray gel: Microbiological performance and in ovo histopathological safety
No full textBackground/Objectives: Oleuropein is a bioactive phenolic compound from olive leaves with antimicrobial and antioxidant activity. This study aimed to develop a sprayable oral gel containing an oleuropein-rich aqueous extract and to evaluate its pharmaceutical performance antimicrobial efficacy and in ovo biological response. Methods: Oleuropein content was quantified using a validated chromatographic method. Polymeric systems were screened to select an optimized sprayable formulation. Physicochemical stability, dose uni formity, and antimicrobial activity against major cariogenic bacteria were evaluated. In ovo biological evaluation was conducted using the chick chorioallantoic membrane angiogene sis model together with histopathological examination of embryonic heart and liver tissues. Results: Oleuropein content was determined as 288.6 µg/mL in the olive leaf extract and 255.1 µg/mL in the final formulation. The optimized oral spray showed stable physico chemical properties, with pH maintained at 6.90 ± 0.02 and no relevant changes in viscosity during storage. The mean delivered dose per actuation was 0.128 ± 0.015 g, corresponding to 32.6 µg oleuropein per spray. The formulation exhibited inhibitory activity against all tested cariogenic microorganisms, with MIC values ranging from 13.3 to 170.7 µg/mL and MBC values generally two-fold higher. In the CAM assay, significant concentration- and time-dependent antiangiogenic effects were observed after 24–48 h at moderate and higher concentrations. Histopathological evaluation revealed dose-dependent acute degenerative and congestive changes in heart and liver tissues without evidence of fibrosis or steatosis. Conclusions: The oleuropein-based sprayable oral gel is a promising localized delivery system with adequate stability dose uniformity and antimicrobial efficacy. In ovo findings provide a conservative assessment of systemic exposure and support further development for oral biofilm and caries-related applications
Association of health-promoting behaviors with oral health status among Turkish dental students: A cross-sectional study
No full textBackground: Oral health is an essential component of overall well-being, and dentistry students are expected to model healthy behaviors. However, their lifestyle habits may not always reflect this role. This study explores the relationship between oral health status and health-promoting behaviors among fourth-year dental students. While the Health-Promoting Lifestyle Profile II (HPLP II) has been widely applied, its use alongside objective oral health indices in this population remains limited. Methods: This cross-sectional study assessed health-promoting behaviors using the Health-Promoting Lifestyle Profile II (HPLP II) and evaluated oral health status using clinical indices, including Decayed, Missing, and Filled Teeth (DMFT) index, Gingival Index (GI), and Plaque Index (PI), among fourth-year dental students. Results: Students with better gingival health exhibited higher overall health-promoting lifestyle scores, particularly in the domains of nutrition and health responsibility. Similarly, participants with better plaque control demonstrated more favorable stress management behaviors. In addition, weak inverse associations were observed between dental caries experience and spiritual growth, as well as between plaque accumulation and overall health-promoting lifestyle behaviors. Conclusion: This study revealed significant links between key health promoting lifestyle domains—nutrition, stress management, and health responsibility—and oral health indicators. These findings underscore the need to integrate structured health promotion modules into dental curricula to improve students’ well-being and clinical competence
Radiographic medial posterior tibial slope ≥16° predicts multiple revisions after anterior cruciate ligament reconstruction
No full textPurpose: An increased posterior tibial slope (PTS) has been implicated as a risk factor for anterior cruciate ligament (ACL) graft failure. This matched case–control study aimed to compare radiographic and magnetic reso nance imaging (MRI)‐based PTS measurements between patients under going multiple revision anterior cruciate ligament reconstruction (ACLR) and those with successful primary ACLR and to identify thresholds predictive of high revision risk. Methods: In this matched case–control study, 156 patients were analysed: 78 patients undergoing multiple revision ACLR and 78 patients with suc cessful primary ACLR. Medial PTS was measured on radiographs, while medial, lateral and PTS difference (PTS asymmetry) were measured on MRI. Group differences were assessed using independent t tests and χ2 tests. Receiver operating characteristic (ROC) analysis identified optimal thresholds, and logistic regression quantified odds ratios (ORs) for multiple revisions per 1° increase in radiographic medial PTS, adjusting for body mass index (BMI), sex, side, height and weight. Results: Radiographic medial PTS was significantly higher in the multiple‐ revision group (12.5 ± 3.5° vs. 11.2 ± 3.0°, p = 0.016). ROC analysis identi fied an optimal medial PTS cutoff of 13° (area under the curve = 0.58, sensitivity = 0.49, specificity = 0.65), but only a PTS ≥ 16° was significantly associated with increased multiple revision risk (OR = 3.10, 95% confidence interval [CI]: 1.14–8.40; p = 0.037; specificity = 0.91; positive predictive value [PPV] = 0.70). MRI‐based medial and lateral PTSs, as well as PTS asymmetry, did not differ significantly between groups. Univariate logistic regression demonstrated a 10% increase in odds per 1° increase in radio graphic PTS (OR = 1.10, 95% CI: 1.00–1.22, p = 0.049), remaining signifi cant after adjustment for BMI, sex, side, height and weight (adjusted OR = 1.11, 95% CI: 1.01–1.23, p = 0.034). Radiographic medial PTS cor related moderately with MRI‐based medial PTS (r = 0.49, p < 0.001), but not with lateral PTS (p: n.s.). Conclusion: Radiographic medial PTS showed the strongest differentiation between successful primary ACLR and multiple‐revision ACLR. A PTS ≥ 16° identifies patients at significantly higher risk of multiple revisions, whereas MRI‐based medial PTS, lateral PTS and PTS asymmetry provide no addi tional discriminatory value. Radiographic medial PTS appears practical for preoperative risk stratification, whereas MRI‐based measures do not show similar utility. Level of Evidence: Level III
ThermoMicrowave-sonication improves the stability and digestive bioaccessibility of phenolic compounds in parsley juice
No full textThese are indications of the effects of ThermoMicrowave Sonication (TMS) on the bioactive compounds of parsley (Petroselinum crispum) juice and their bioaccessibility during in vitro digestion. Total phenolic content (TPC), iron-reducing antioxidant power (FRAP), chlorophyll, and ascorbic acid levels were measured in TMS treated and pasteurized samples. TMS minimized the loss of heat-sensitive proteins and significantly increased the phenolic content and antioxidant structure (p 0.99) for antioxidant capacity. Overall, TMS offers a promising, environmentally friendly, and industrially applicable tool for preserving and ensuring bioaccessibility of bioactive images in parsley juice and valuable information for functional electrical development. Chemical compounds: Gallic acid (PubChem CID:370); flovone (PubChem CID: 10680); vanillic acid (PubChem CID: 8468); rutin (PubChem CID: 5280805); naringin (PubChem CID: 442428); p- coumaric acid (PubChem CID: 637542); o- coumaric acid (PubChem CID: 637540); quercetin (PubChem CD: 5280459); alizarin (PubChem CD: 6293)