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Long-Term Survival with Daratumumab, Lenalidomide and Dexamethasone in Transplant-Ineligible Newly Diagnosed Multiple Myeloma Patients — A Survey from Two Italian Centers
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Novel Therapeutic Strategies Targeting EZH2 and NLRP3 in Oral Squamous Cell Carcinoma
No full textOral squamous cell carcinoma (OSCC) is one of the most common and aggressive human
malignancies worldwide, characterized by high rates of proliferation, invasiveness, and
metastasis. Despite the use of surgical resection, chemotherapy, and radiotherapy as standard
treatments, OSCC still shows poor prognosis and low survival rates, highlighting the urgent
need for novel therapeutic strategies. Among the molecular mechanisms implicated in OSCC
progression, recent evidence has identified a key role for both the NLRP3 inflammasome and
the epigenetic regulator EZH2. This study aimed to evaluate the effects of two selective
inhibitors: BAY 11-7082, targeting the NLRP3 inflammasome, and GSK343, an EZH2 inhibitor
through both in vitro and in vivo approaches. BAY 11-7082 (5, 10, and 30 μM) significantly
reduced OSCC cell viability and decreased the expression of NLRP3, ASC, caspase-1, IL-1β,
and IL-18. It also enhanced pro-apoptotic markers such as Bax, Bad, and p53, while reducing
anti-apoptotic Bcl-2. In xenograft mouse models, BAY 11-7082 (2.5 and 5 mg/kg) decreased
tumor mass and suppressed inflammasome activation. Similarly, GSK343 (1, 10, and 25 μM)
reduced OSCC cell viability and migration in vitro by inhibiting EZH2 and modulating
NFκB/IκBα signaling, as well as angiogenesis-related markers (eNOS, VEGF, TGFβ). In
orthotopic mouse models, GSK343 (5 and 10 mg/kg) restored tissue architecture and reduced
tumor growth via EZH2 and Wnt/β-catenin pathway modulation, also decreasing CD31 and
CD34 expression. These findings support the potential therapeutic role of BAY 11-7082 and
GSK343 in OSCC by targeting key inflammatory and epigenetic pathways involved in tumor
progression
Highly yield of blue photoluminescence in rehydrated Sargassum muticum algae at room temperature
No full textThe rehydration process of air-dried algae Sargassum muticum using distilled water produces a highly blue photoluminescent liquid under UV excitation. The cause of this effect is the release of small nanoparticles and molecules exhibiting quantum dot behavior, which are strongly absorbent in the near-UV region and emit visible luminescence. The aim of this work is twofold: to describe the surprising behaviour of the Sargassum muticum algae when they are rehydrated at room temperature, determining their molecular release in water, and to examine their molecules and small released aggregates that appear photoluminescent under UV excitation. Rehydration appears to cause the release of nanometric-sized molecules into the liquid, primarily due to polysaccharides and phenols, i.e., hydrocarbon nuclei released by the algae, which act as quantum dots dispersed in the liquid. The absorption of UV light at 365 nm induces luminescence in the visible wavelength region with high emission in the blue band, around 478 nm. Characterization measurements of the biocompatible luminescent liquid were performed using optical spectroscopy in the UV, Visible, and IR ranges, as well as optical and electron microscopy. Possible applications of such a liquid, including bioimaging, diagnostics, and therapy, as well as the potential to create luminescent films and devices, are proposed, and some are described
Messina è una vertigine. Sopralluoghi e discorsi sul paesaggio
No full textQuesto testo fa parte di una serie di studi che considerano la città come un orizzonte cruciale per le sfide del progresso equo, della sostenibilità ambientale e della coesione sociale. Esso si basa in gran parte sulla metodologia del camminare e sulla lettura decostruttiva del paesaggio e intende testimoniare l'iniziativa di ricerca e azione culturale di un collettivo interdisciplinare e multimediale chiamato Sopralluoghi, dedicato alla lettura critica del paesaggio della città di Messina e dello Stretto
Well-being in romantic relationships: the role of motivation and conflict engagement
No full textRelationship science emphasises that most people desire romantic relationships. Self-determination theory provides a theoretical approach that can capture the variety of motivations potentially underlying the pursuit of romantic relationships. Within this framework, couple and sexual motivations can help us to understand why people are in relationships, what motivates them to stay together and what can increase the risk of conflict. Indeed, how couples manage conflict can explain personal and couples' well-being within close relationships. Grounded in self-determination theory, a Structural Equation Model was tested to investigate the role of couple and sexual motivation by both partners in associating couple and individual well-being by both. We also examined whether conflict engagement played an intervening role in associations of motivation with well-being. 402 heterosexual young adult couples, aged 20 to 30, who had been in a stable relationship for between 1 and 5 years, participated in the study via a snowball recruitment technique. Using the Actor Partner Interdependence Model (APIM), results showed that couple motivation in both partners is positively related to their own couple and individual well-being. Female sexual motivation is positively related to their own individual well-being. An indirect association is found in both partners between couple motivation and individual well-being through the mediation of conflict engagement. In line with SDT, motivation emerges as a critical factor in the promotion of both individual and couple well-being and in the adoption of functional conflict resolution strategies. The theoretical and practical implications of the findings for future research and interventions are discussed
Real-world effectiveness and safety of guselkumab in adult patients with facial and/or genital psoriasis: a 52-week analysis from the Italian multicentric GULLIVER study
No full textObjectives: Facial and genital plaques are common manifestations of psoriasis, are challenging to treat, and significantly impact patients’ quality of life (QoL). Methods: GULLIVER is a prospective, non-interventional study conducted in 2020–2023 in Italy, aimed at examining the effectiveness, safety and QoL impact of guselkumab through 52 weeks of treatment in patients with facial and/or genital psoriasis. The primary endpoint was the percentage of patients achieving a static Physician Global Assessment (sPGA) score of ≤1 and a minimum 2-grade improvement in sPGA score at Week 52. Results: Of 351 enrolled patients, 88.6% remained on guselkumab treatment at Week 52. The proportions of patients achieving the sPGA targets in the facial and genital groups, respectively, were 83.3% and 76.5% at week 12, increasing to 93.8% and 97.9% at Week 52. Mean Dermatology Life Quality Index score improved from 12.0 ± 7.5 at baseline to 1.1 ± 2.0 at Week 52 for patients with facial psoriasis (p-value <0.001) and from 12.0 ± 6.9 to 1.6 ± 3.5 for those with genital psoriasis (p-value <0.001). Guselkumab was well-tolerated and no new safety signals were identified. Conclusions: This Italian real-world study demonstrated the high effectiveness and a good safety profile of guselkumab in treating facial and genital psoriasis
Copycat Behavior and Somatic Symptoms in Italian Children Exposed to a Violent TV Series: An Observational Study of Squid Game Viewers
No full textBackground: Violent TV series and streaming content are increasingly accessible to children, raising concerns about behavioral imitation and psychological effects. This study examined copycat behaviors and associated emotional and somatic symptoms among children who reported watching the age-restricted series Squid Game. Methods: In this observational study of 228 Italian primary school children (aged 8-11), 128 who had watched Squid Game formed the analytic sample. They were categorized into a Copycat Behavior (CB) group or a Non-Copycat Behavior (NCB) group based on self-reported imitation of scenes or games from the series. Parents completed the Child Behavior Checklist (CBCL). Group differences were assessed using Mann-Whitney U tests, and gender distribution was compared with Chi-square tests (alpha = 0.05). Results: Among viewers, 42 children (32%) engaged in imitation behaviors, typically reenacting game-based violent scenes with friends (52%), siblings (28%), or classmates (20%). Age and gender distributions did not differ between groups. The CB group scored slightly higher on the CBCL Somatic Complaints scale compared with the NCB group (M = 54.12 vs. 52.92; U = 1414.5, p = 0.033), although this difference was small. No significant differences emerged on other CBCL syndrome or broadband scales. Conclusions: Among children engaging in copycat behaviors exhibited a small, subclinical increase in somatic complaints. While causality cannot be inferred, the findings highlight the need to protect vulnerable children-particularly those prone to somatic distress-from unsupervised access to violent, age-inappropriate content. Media literacy for parents and educators, and longitudinal studies including non-viewers are recommended
