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Insanity in the Works of W.G. Wills
No full textThe chapter aims at a re-evaluation of the works of a once famous and now
largely forgotten Victorian playwright, William Gorman Wills. Wills was once
largely considered the most eminent poetic dramatist of the Victorian age, but
the majority of his works are now forgotten, mostly due to the Ibsenist
theatrical trends that came into full swing shortly after his death. His widely
reported desultory working habits, his tendency to hoarding, and mood swings,
which even his contemporaries struggled to define within the boundaries of
the Victorian byword, “eccentricity”, clearly point to a constant struggle with
crippling mental issues. The chapter focuses on Juanna and The Love That Kills
to highlight how Wills explores, with deep sympathy and no trace of idealization
or recurse to literary stereotypes, the dynamics of female and masculine mental
disorders, the latter theme especially tabooed by the Victorian cult of
masculinity and all-pervasive Carlylean anti-Werterism
Critical Agency and Creative Imagination: Snapshots of the Future Among Youth Networks of Activism in Italy
No full textKairos is the fragile catching-up with the right moment; today when it happens in the high complexity in which we are living, it lets us glimpse what a sustainable future could be. This effort is crucial for contemporary youth movements that – especially with the economic “great recession,” the pandemic, and the emergency of climate change – tackled with uncertainty, individualization and crisis of representative politics. The aim of this chapter is to analyze this systemic issue with the help of a research fieldwork in Italy, based on the analysis of a network of experiences of youth mobilizations as reinvention of politics, characterized by the encounter of personal meaningful activities and innovative forms of cooperation in different fields, from worker rights to environment protection. These creative experimentations of emancipative activism, rooted in everyday troubles, in the local dimension, in horizontal relations, ina strategy characteristic of a time where the future can be glimpsed mainly from local and concrete experiences, rather than based on abstract long-term visions. the mutual recognition of fragility, represent a form of critical agency, but also These creative experimentations of emancipative activism, rooted in everyday troubles, in the local dimension, in horizontal relations, in the mutual recognition of fragility, represent a form of critical agency, but also a strategy characteristic of a time where the future can be glimpsed mainly from local and concrete experiences, rather than based on abstract long-term visions
Gadamer, Platone e la concezione ermeneutica della verità
No full textIl dialogo ininterrotto con Platone segna tutto il percorso di pensiero di Hans-Georg Gadamer, padre dell’ermeneutica filosofica contemporanea. Ed è proprio nel serrato confronto con Platone che egli sviluppa, attraverso una peculiare rielaborazione-appropriazione, molte delle acquisizioni fondamentali della sua filosofia. Questo contributo si concentra, in particolare, sul duplice e determinante influsso platonico sulla complessa concezione gadameriana della verità. Se, da una parte, la verità ermeneutica, in quanto caratterizzata da un’inaggirabile componente dialogico-dialettica (dianoetica), guarda evidentemente al modello platonico-socratico di quell’indispensabile e faticoso lógon didónai che si costruisce solo attraverso lo scambio dialogico con l’altro, d’altra parte anche il secondo aspetto eminente della verità ermeneutica, quello puramente noetico, è guadagnato da Gadamer a partire da Platone, come dimostra la sua illuminante interpretazione, in Verità e metodo, di un celebre passaggio del Fedro
GENOMIC CHARACTERIZATION AND IDENTIFICATION OF THERAPEUTIC APPROACHES IN UNRESOLVED HEREDITARY LEUKODYSTROPHIES
No full textHereditary leukodystrophies and neurodevelopmental disorders represent heterogeneous groups of rare pediatric neurological diseases that remain difficult to diagnose despite advances in genomic medicine. Many affected individuals remain without a molecular diagnosis, reflecting the complexity of the underlying genetic architecture and the limitations of conventional sequencing approaches.
This thesis aimed to improve the molecular diagnosis and characterization of unresolved leukodystrophies and neurodevelopmental disorders through the integration of advanced genomic technologies, detailed clinical phenotyping, and functional validation. Patients were recruited through international collaborations across neurogenetics centres in Italy and the United Kingdom and underwent comprehensive clinical evaluation, neuroimaging, and genomic analyses using whole exome sequencing, whole genome sequencing, and long read sequencing.
The study identified novel variants in known disease genes and expanded the genetic and phenotypic spectrum of several neurogenetic conditions, including ATP6V1B2, SLC9A1, ITPR1, VPS13D, TUBB4A, and SLC25A15. In addition, translational investigations led to the identification of MED11 as a novel disease gene and the nomination of eEF2K as a candidate gene for hypomyelinating leukodystrophy.
Overall, this work highlights the value of integrating genomic sequencing, functional studies, and international collaboration to reduce the diagnostic gap in rare neurogenetic disorders and to advance the understanding of the molecular mechanisms underlying leukodystrophies and neurodevelopmental diseases
Verso un (non più chimerico) ripensamento del sistema giudiziario francese: marital rape tra anacronismo giurisprudenziale e norme convenzionali, in Nullum Crimen, Rivista quadrimestrale di scienze penalistiche, 14 gennaio 2026.
No full textLa sentenza della Corte europea dei diritti dell’uomo in commento si pronuncia sull’inquadramento assiologico dell’astensione prolungata dai rapporti sessuali all’interno del matrimonio nel settore dei doveri coniugali ravvisando, nella vicenda di specie, la violazione dell’articolo 8 della Convenzione. La decisione s’inserisce in un momento di particolare subbuglio della politica criminale francese sulla criminalità sessuale: la recentissima riforma (già ribattezzata la loi Pelicot), entrata in vigore lo scorso 8 novembre, introduce, con un aspetto di storica novità, l’elemento del consenso della vittima nella fattispecie di reato di stupro e altre aggressioni sessuali
Resilience Indicators for a Road Transport Network to Access Emergency Health Services
No full textThe resilience concept, born for ecological systems, has been successfully adapted to other domains. Considering the case of transport networks, the evaluation of resilience is crucial to ensure their functionality. The objective of this paper is to provide a set of indicators that can be used to quantify the resilience of a transport network with particular attention to the access to emergency health services. The methodology adopted allows for obtaining some centrality measures and some metrics on network efficiency, to identify the most critical nodes and arcs in the network, and to determine how the removal of nodes/arcs affects efficiency. In this study, the resilience indicators of the road network of Messina, a city located in the northeastern tip of Sicily (Italy), are analyzed. The analysis focuses on three main emergency hospital facilities and, by examining the connectivity of the road network, the accessibility to these critical centers in different scenarios will be assessed. A relevant aspect of the proposed methodology is the exclusive use of open data in road network definition, which makes the procedure easily transferable to other areas. The results of the proposed application provide useful indications for improving road infrastructure and urban planning, as well as replicating the methodology in other geographical areas
Tutela della persona umana e cyberbullismo. La prospettiva costituzionalista
No full textL'elaborato analizza il cyberbullismo come fenomeno lesivo dei diritti della personalità nell’ecosistema digitale, evidenziando come la struttura del web (persistenza, replicabilità, diffusione potenzialmente illimitata) amplifichi l’offesa e renda centrali rimedi rapidi ed effettivi. Muovendo da una prospettiva costituzionalista, la ricerca ricompone una materia frammentata attraverso il principio personalista e il bilanciamento tra diritti fondamentali, con particolare attenzione all’identità digitale e alla tutela della dignità del minore. L’indagine ricostruisce, sul piano interno, l’evoluzione normativa (con focus sulla l. 71/2017), gli strumenti amministrativi (ammonimento del questore e ruolo del Garante) e le principali forme di tutela giurisdizionale, soprattutto in tema di responsabilità genitoriale e delle fattispecie penali rilevanti. In chiave comparata, esamina l’ordinamento spagnolo, soffermandosi sul rilievo costituzionale della dignidad e sulla tutela penale dell’acoso persecutorio. Infine, nella dimensione sovranazionale, valorizza il passaggio dalla direttiva 95/46 al GDPR e la responsabilizzazione dei titolari del trattamento, anche attraverso la prova liberatoria ex art. 82, come snodo per i rapporti vittima–piattaforma
Numerical Simulations and Experimental Tests for Tailored Tidal Turbine Design
No full textThis paper outlines the design and testing of a horizontal-axis tidal turbine (HATT) at a scale of 1:20, employing numerical simulations and experimental validation. The design employed an in-house code based on the Blade Element Momentum (BEM) theory. As reliable lift and drag coefficients for this scale are not present in the literature due to the low Reynolds number of the airfoil, Computational Fluid Dynamics (CFD) simulations were conducted to generate accurate polar diagrams for the NACA 4412 airfoil. The turbine was then 3D-printed and the rotor tested in a subsonic wind tunnel at various fixed rotational speeds to determine the power coefficient. Fluid dynamic similarity was achieved by matching the Reynolds number and tip-speed ratio in air to their values in water. Three-dimensional CFD simulations were also performed, yielding turbine efficiency results that agreed fairly well with the experimental data. However, both the experimental and numerical simulation results indicated a higher power coefficient than that predicted by BEM theory. The CFD results revealed the presence of radial velocity components and vortex structures that could reduce flow separation. The BEM model does not capture these phenomena, which explains why the power coefficient detected by experiments and numerical simulations is larger than that predicted by the BEM theory
Hemotropic mycoplasmas and Bartonella spp. in dogs from Southern Italy: prevalence and risk factors
No full textCanine vector-borne diseases (CVBDs) include several zoonoses and represent an important concern where veterinarians play a major role. Although usually responsible for asymptomatic infections in animals and humans, these agents may also have fatal consequences in immunocompromised patients. In this study, different categories of dogs from the Campania region (southern Italy) were investigated for three canine vector-borne bacteria (i.e., Candidatus Mycoplasma haematoparvum, Mycoplasma haemocanis, and Bartonella spp.) by using specific real-time PCR protocols. Out of 187 dogs, 45 (i.e., 24.1%) tested positive for at least one pathogen, with Candidatus Mycoplasma haematoparvum (14.4%) being the most prevalent, followed by Mycoplasma haemocanis (12.8%) and Bartonella spp. (1.6%). Coinfections with more than one agent were observed in 4.8% of the samples. The analysis of risk variables indicated province, activity, and lifestyle as risk factors associated with greater prevalence values. Non-hunting dogs (OR = 0.11) showed a significantly lower likelihood of being positive for at least one infection. Living outdoors (OR = 3.46), in Salerno province (OR = 13), had a higher likelihood of testing positive for at least one hemotropic species. These findings revealed a wide distribution of CBVDs in dog populations of the study area, clearly underlining the necessity for effective efforts to minimize ectoparasite activity
PATHWAY MOLECOLARI CHIAVE NELL’ENDOMETRIOSI: DALLA PROLIFERAZIONE CELLULARE ALLA SENSIBILIZZAZIONE DEL SISTEMA NERVOSO CENTRALE
No full textL'endometriosi è una malattia ginecologica gravemente invalidante caratterizzata dallo sviluppo di tessuto endometriale in maniera eccessiva con sintomi molto dolorosi. A livello molecolare vi sono infiammazione, stress ossidativo, neuroinfiammazione e dolore cronico. Questo studio si propone di indagare i meccanismi molecolari alla base della patologia e come questi possano essere modulati dalla somministrazione di un composto di origine naturale, Hericium erinaceus (HER). Per il nostro studio abbiamo utilizzato un modello in vivo: l’endometriosi è stata indotta tramite la somministrazione per via intraperitoneale di frammenti uterini provenienti da animali donatori. Per tutta la durata dell'esperimento, gli animali sono stati tenuti sotto stretto monitoraggio. L'HER, somministrato per via orale, è stato in grado di ridurre le dimensioni e la morfologia istologica delle lesioni. A livello molecolare, l’estratto ha limitato la proliferazione cellulare, riducendo i livelli di alcuni marker come di Ki-67 e PCNA e l’attivazione della via di segnalazione MAPK. Inoltre è stata ripristinata l'apoptosi, come dimostrato dall’analisi quantitativa RT-PCR per i livelli di Bax, Bcl- 2 e Caspasi. Non solo, l’HER ha anche importanti proprietà antiossidanti e antinfiammatorie: agisce, infatti, riducendo l'espressione di Nox, l'attività MPO e i livelli di MDA, ripristinando l'attività di SOD e i livelli di GSH, oltre a ridurre i livelli delle citochine infiammatorie. Inoltre, l’HER è in grado di modulare i comportamenti dolorosi associati alla patologia, agendo sull'espressione dei mediatori neuro- sensibilizzanti c-FOS e NGF, riducendo anche l’attivazione degli astrociti come dimostrato dall’espressione di GFAP nel midollo spinale, nella corteccia cerebrale e nell'ippocampo. Nel complesso, i dati da noi ottenuti in questo studio hanno dimostrato come la somministrazione dell’estratto di origine naturale sia in grado di modulare le diverse vie molecolari coinvolte nella progressione dell’endometriosi