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Re_actShap : détection de rebranchements des réseaux de régulation d’expression génique à l’aide des valeurs SHAP
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Quantitative study of microplastic degradation in urban hydrosystems: Comparing in situ environmentally aged microplastics vs. artificially aged materials generated via accelerated photo-oxidation
No full textInternational audienceThe degradation of plastic waste is a major research challenge due to the adverse impacts of microplastic weathering on the environment and ecosystems. As a major source of plastic contamination comes from urban hydrosystems, studying MP degradation prior to their environmental dissemination is crucial. Through a combination of field sampling and laboratory experiments, this study provides a thorough statistical degradation comparison analysis between polyethylene in situ environmentally aged microplastics and artificially aged films. In the laboratory, pristine nonadditivated low-density polyethylene films were exposed to controlled ultraviolet (UV) radiation to simulate aging for various durations. Firstly, the study aims to assess the representativeness of controlled UV degradation to mimic urban in-situ MPs. The second goal is to identify polyethylene (PE) degradation characteristics in various environmental matrices such as stormwater, suspended solids and sediment samples from a stormwater detention basin in a large urban area in France. Artificially aged plastics exhibit distinct alterations in physical and chemical properties, corresponding solely to the abiotic degradation observed in-situ. In contrast, environmental particles display notable markers of biotic chemical degradation and hydrolysis. Moreover, the degradation environment varies significantly: it is predominantly abiotic for MPs collected in stormwater samples, while it is largely biotic for MPs collected in sediment and suspended solid samples. Besides, MPs from stormwater and suspended solid samples show a higher degree of hydrolysis degradation. Finally, additional comparisons with common consumer materials, before and after use, show almost no signs of notable degradation compared to the environmentally and artificially aged materials considered in this study
A mathematical model to the melanoma dynamics involving CAR T-cells
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Low-frequency magnetic incremental permeability for the non-destructive evaluation of hardness profile after carburization treatment with large case hardening depth
No full textInternational audienceCarburization treatment with large case hardening depth is a technical process to enhance steel parts' surface hardness and wear resistance. Accurate evaluation of this metallurgical treatment is crucial to prevent critical mechanical failures. Low-frequency magnetic incremental permeability (LF-MIP) emerges as a non-destructive surface technique well-suited for this purpose in the case of ferromagnetic parts. Although correlations between magnetic indicators obtained through LF-MIP characterization and deep carburization treatment have been demonstrated, they remain qualitative. In this study, we propose an innovative method to assess the entire hardness profile based on LF-MIP characterization. Experimental results and simulation data are integrated into a reference chart used for post-processing, enabling the prediction of hardness profiles for specimens in a blind test. With a relative Euclidean distance of less than 6% between the method's predictions and destructive tests conducted on specimens treated with medium, deep, and intense intensities, we consider the method validated.</div
Network-Based Molecular Descriptors for Protein Dynamics and Allosteric Regulation
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A data driven approach using local measurements to locate turbine governors causing forced oscillations
No full textInternational audienceThis paper presents a method based on residual analysis and system identificationtechniques to localize the source of forced oscillations in power systemsdue to turbine governors in power plants. The method identifies the closed loopdynamics of power plants described by the swing equation. When forced oscillationsare detected, they are located by finding the transfer functions thatdescribe the behavior of the corresponding plant the worst. The method presentedin this paper locates the source of forced oscillations based only on localmeasurements at each plant. This may represent an inherent advantage sinceit may reduce the need of data measurement and communication. We investigatehow the method performs under different process noise levels and alsothe common assumption that frequency measurements are a sufficient approximationof the machine’s rotational speed. The performance of the method isdemonstrated with an hardware-in-the-loop approach on an experimental setupincluding a real time simulator and phasor measurement units. Sensitivities ofthe method to different forced oscillations and assumptions are analysed usingnumerical simulations
Partition identities from higher level crystals of
No full text15 pages, 2 figuresInternational audienceWe study perfect crystals for the standard modules of the affine Lie algebra at all levels using the theory of multi-grounded partitions. We prove a family of partition identities which are reminiscent of the Andrews-Gordon identities and companions to the Meurman-Primc identities, but with simple difference conditions involving absolute values. We also give simple non-specialised character formulas with obviously positive coefficients for the three level 2 standard modules
Multivariable -modules and local-global compatibility
No full textInternational audienceLet be a prime number, a finite unramified extension of and a finite extension of . Using perfectoid spaces we associate to any finite dimensional continuous representation of over an étale -module over a completed localization of . We conjecture that one can also associate an étale -module to any smooth representation of occurring in some Hecke eigenspace of the mod cohomology of a Shimura curve, and that moreover is isomorphic (up to twist) to , where is the underlying 2-dimensional representation of . Using previous work of the same authors, we prove this conjecture when is semi-simple and sufficiently generic
La ville et ses calculs
No full textInternational audienceLa ville se développe depuis des siècles en s’appuyant sur des bâtisseurs toujours plus ingénieux. Calculer un angle droit sans équerre avec une corde à 13 nœuds ou définir des éléments techniques qui permettent de construire un édifice, se fait grâce à une technicité toujours plus importante demandant une maîtrise de la géométrie initiée par Pythagore, Euclide ou Thalès. Construire toujours plus haut, toujours plus vite a amené l’humain à s’outiller. Comment utiliser la puissance de la vapeur pour aider dans la manutention et le levage d’objets ? Comment passer de la règle à calcul à des outils plus appropriés afin de calculer plus vite, plus précisément, et assouvir les ambitions des architectes et urbanistes ? L’expert s’est doté d’outils et fait aujourd’hui appel de façon prégnante au numérique. Il est possible d’enregistrer des phénomènes à l’aide de capteurs, de produire de manière automatique ou assistée des données représentant la ville et les territoires, et même de leur adjoindre des outils de simulation afin de mieux les comprendre et de caractériser leurs possibles évolutions. Ces approches contribuent à l’élaboration de répliques des territoires, appelées « Jumeaux Numériques » . La ville se construit et se transforme grâce à ces données et ces outils, et les exemples ne manquent pas
Twelve Years of LabEx PRIMES (2012-2024)
No full textInternational audienceAn overview of the research performed in the Auvergne Rhône Alpes Region within theLaboratoire d’Excellence Physics, Radiobiology, Medical Imaging, and Simulatio