Portail HAL de l'Université Picardie Jules Verne
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A case report of wrist arthritis caused by Gemella haemolysans
No full textInternational audienceBackground: Septic wrist arthritis is rare and usually due to Staphylococcus aureus. Gemella haemolysans is exceptionally involved in osteoarticular infection, mainly reported in prosthetic infections or spondylodiscitis.Case presentation: A 45-year-old woman on haemodialysis, co-infected with HBV-HIV (CD4 152/µL) and untreated multiple myeloma, presented with 10-day fever (39.5 °C) and right-wrist swelling. Synovial fluid and blood cultures grew G. haemolysans (MALDI-TOF score 2.31). MICs: amoxicillin 0.5 mg/L, clindamycin 0.5 mg/L, gentamicin 16 mg/L. Echocardiography excluded endocarditis. Treatment by amoxicillin (3 g/day IV, renal adjusted) alone failed to achieve clinical or biological improvement. The addition of clindamycin 600 mg IV every 6 h resulted in complete resolution of symptoms and normalization of inflammatory markers after five weeks of dual therapy.Conclusion: This case illustrates the potential limits of monotherapy with beta-lactams in native joint infections caused by G. haemolysans, especially in immunocompromised patients. The failure of amoxicillin may be explained by factors such as limited diffusion into joint tissues, the absence of surgical debridement, and the use of pharmacokinetic and pharmacodynamic breakpoints not specifically validated for this rare species. Early reassessment and combination therapy may be warranted, particularly in immunocompromised individuals
The Centre-Val de Loire region (France) in relation to the Middle Miocene climatic optimum: a more accurate stratigraphic dating
No full textInternational audienceBetween -16.9 and -13.8 Ma a hyperthermal event called the Middle Miocene Climatic Optimum (MMCO) took place (Hansen et al. 2013). During the MMCO, the climate in Western Europe was subtropical to semi-arid (Costeur & Legendre 2008), with temperatures 4 to 5 °C higher than today (Hansen et al., 2013). The Centre-Val de Loire region, located south-west of the Paris Basin, was characterised by various depositional environments (lacustrine, fluvial and shallow-marine; Fig. 1) (Mégnien et al. 1980), recorded in 5 Formations encompassing the Miocene and thus providing geological data for the entire MMCO: 1- The Beauce lacustrine limestone formation (Oligocene-Aquitanian), which covers a large part of Beauce and Sologne (Ginsburg, 2000). 2- The Orléanais and Blésois sand and marl formation (Burdigalien-Langhien), which extends between Orléans and Angers, corresponds to a series of terrigenous sediments of fluvio-lacustrine origin. These sediments are channelized by folded plicative East-West tectonic structures inherited from the Alpine orogeny. 3- The Faluns Formation (Langhien), which is a shallow marine lateral equivalent of the Orléans and Blésois sands and marls. It is exposed from the Loire-Atlantique to Blois. Locally, the marine sedimentation continues until the Tortonian (Gagnaison 2020). 4 & 5- The fluvio-lacustrine formation of the Sologne sands and clays (Middle Miocene-Pliocene), which outcrops in the east of the Loire sedimentary basin and grades westwards to the Redonian marine sands formation. The aim of this study is to refine the dating of these different sedimentary formations to characterize the palaeoenvironmental changes associated to the MMCO
Investigating Infants’ Responses to Infant-Directed Singing Using Eye-Tracking
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#693 Hospitalization for congestive heart failure following treatment with roxadustat in patients with or without a history of CHF: pooled post hoc analysis of phase 3 studies
No full textInternational audienceBackground and Aims Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, is approved in multiple countries for the treatment of anemia of chronic kidney disease (CKD). Previous pooled analyses have reported that roxadustat was non-inferior to erythropoiesis-stimulated agents (ESAs) for time to first major adverse cardiovascular event (MACE) and MACE plus congestive heart failure (CHF) or unstable angina requiring hospitalization in patients with dialysis-dependent (DD) or non–dialysis-dependent (NDD) CKD; however, these analyses were not stratified by history of CHF. The current post hoc analysis was conducted to evaluate time to first hospitalization for CHF in patients with DD or NDD CKD with or without a history of CHF treated with roxadustat compared with ESA. Method Patients with anemia of CKD from four phase 3, multicenter, randomized, open-label, active-comparator studies (HIMALAYAS, ROCKIES, SIERRAS, and PYRENEES) were pooled for the DD CKD group, and patients from a phase 3, multicenter, randomized, open-label, active-comparator study (DOLOMITES) were analyzed as the NDD CKD group. Data were analyzed for the time to first occurrence of hospitalization for CHF during and up to 7 days after the treatment period (ie, on-treatment plus 7 days) using a separate model for each of the four groups (DD CKD with a history of CHF, DD CKD without a history of CHF, NDD CKD with a history of CHF, and NDD CKD without a history of CHF). Hazard ratios (HRs) were estimated with a Cox proportional hazards model adjusted for baseline age as a continuous covariate. The non-inferiority margin was set at 1.8, as recommended by industry guidance provided by health authority bodies regarding the assessment of cardiovascular risk in clinical studies. Results Of the 4714 patients with DD CKD (roxadustat: n = 2354; ESA: n = 2360), 1122 had a history of CHF (roxadustat: n = 562; ESA: n = 560). Of the 616 patients with NDD CKD (roxadustat: n = 323; ESA: n = 293), 158 had a history of CHF (roxadustat: n = 81; ESA: n = 77). In the DD CKD group, treatment with roxadustat demonstrated noninferiority to ESA treatment in patients with no history of CHF (HR [95% CI]: 0.85 [0.64, 1.14]) and in patients with a history of CHF (0.97 [0.67, 1.39]; Table 1), both with the upper limit of the confidence limit less than the non-inferiority margin of 1.8. In the NDD CKD group, treatment with roxadustat demonstrated noninferiority to ESA treatment in patients with a history of CHF (0.62 [0.25, 1.51]). The noninferiority margin was not achieved (upper limit of the confidence interval ≥1.8) in patients with NDD CKD with no history of CHF (1.31 [0.57, 2.99]; Table 1). These results are difficult to interpret due to the low number of events included in the analysis; this increased uncertainty is evident in the wider confidence interval. Conclusion In patients with DD CKD, regardless of history of CHF, and in patients with NDD CKD with a history of CHF, the results from this post hoc analysis suggest that treatment with roxadustat is non-inferior to ESA for the risk of hospitalization for CHF. In patients with NDD CKD without a history of heart failure, the results should be interpreted cautiously due to the low number of events included in this analysis
Biostimulant Effects of Rich Mannuronate-Alginate and Their Thermic-Acidic Depolymerized Derivates on Triticum aestivum
No full textInternational audienceWheat (Triticum aestivum L.) productivity is frequently compromised by environmental stressors such as drought, salinity, and nutrient deficiencies. The application of biostimulants has emerged as a promising strategy to mitigate these challenges by enhancing plant growth, resilience, and nutrient uptake. This study investigates the biostimulant effects of alginate gels and their depolymerized derivatives, particularly alginate oligosaccharides (AOS), on wheat seedling development. Treatments were applied in hydroponic systems at 50 and 500 mg/L to assess morphological and physiological responses. Depolymerized alginates, especially AOS at 500 mg/L, enhanced root length, compared to control by 40% (Kruskal–Wallis; p.adj ≤ 0.001). Smaller oligomers (<2 kDa) showed better biological activity compared to larger molecules (Mw > 2 kDa). Indeed, AOS application modulated oxidative stress by improving the ascorbate/dehydroascorbate (AsA/DHA) ratio as the control, indicating a stronger antioxidant response and a reduced ROS accumulation without stress. These findings suggest that AOS not only promotes root and shoot growth but also enhances the plant’s endogenous ability to mitigate oxidative damage. The dual action, growth promotion and stress tolerance, position AOS as a promising biostimulant for improving wheat productivity in environmentally challenging conditions
Effect of Incorporation of Mg on LiTa0.6Nb0.4O3 Photocatalytic Performance in Air-Cathode MFCs for Bioenergy Production and Wastewater Treatment
No full textInternational audienceMicrobial fuel cells are a new alternative for sustainable energy generation and wastewater treatment technology. To scale up this technology, cost-effective electrodes are required. The electrochemical reduction of oxygen at the cathode is a key reaction for power generation. Noble metals, especially Pt, are extensively used as cathode catalysts in MFC; however, its application is limited to its high cost and catalyst poisoning. Ferroelectric materials are reported as a good candidate due to their spontaneous polarization. The main objective of this study is to prepare and characterize the cost-effective ferroelectric materials LiTa0.6 Nb0.4 O3 and Li0.95 Ta0.57 Nb0.38 Mg0.15 O3 in order to test their catalytic activity in air-cathode MFC. Powders were prepared following the solid-state synthesis and characterized using Scanning Electron Microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction. To evaluate the electrochemical performance of the catalysts, electrochemical studies such as EIS, CV, LSV, and CA were conducted. In MFC, the performance of our material has been investigated using COD determination and polarization measurement. The obtained results demonstrate the potential of Li0.95 Ta0.57 Nb0.38 Mg0.15 O3 as a low-cost and effective catalyst material in MFCs, showing a high COD removal up to 75%, and power-density output of 764 mW/m2
