Portail HAL de l'Université Picardie Jules Verne
Not a member yet
32425 research outputs found
Sort by
Dyadic analysis of parenting stress in parents of deaf children
No full textInternational audienceHearing parents of deaf children may face parenting stress related to the multiple challenges associated with deafness. Several factors may contribute to the level of stress they encounter. This study examined the dyadic relationships between fathers’ and mothers’ parenting stress and potential associated factors. Twenty-one French parental couples of deaf children completed questionnaires assessing parenting stress, parental involvement, parental self-efficacy, and social support needs. The results revealed significant associations between parenting stress and the three measured factors—parental involvement, parental self-efficacy, and social support needs—for both fathers and mothers. These 3 factors were also found to be interrelated. While overall patterns were similar between mothers and fathers, certain differences emerged within specific subdomains. Dyadic analyses further showed cross-parent effects; for instance, lower paternal involvement was associated with higher maternal parenting stress. These findings underscore the importance of including both parents in parenting research and highlight the value of dyadic analysis. Such an approach supports the development of early interventions that are both universal and tailored to the needs of each family
A comprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals
No full textInternational audienceMammalian fertilization involves the migration of spermatozoa through the female reproductive system. Early embryonic development is a consequence of several steps and signaling pathways being activated, as well as biochemical and morphological modifications of spermatozoa that enable them to penetrate the membrane of mature oocytes. There are some crucial steps known to clearly explain the process of fertilization, starting with hyperactivation of spermatozoa, mutual recognition, and binding of gametes mediated by receptors located on the surface membranes of both gametes. The final step is followed by oocyte activation, which is primarily triggered via sperm-derived factors, inducing a sharp increase in intracellular calcium levels, eventually leading to polyspermy block. This review integrates current knowledge of the molecular and physiological events governing fertilization, emphasizing how ion regulation and signaling pathways converge to enable sperm function and oocyte activation. Special attention is given to sperm-derived factors such as phospholipase C zeta (PLCζ) and post-acrosomal sheath WW domain-binding protein (PAWP), which play essential roles in triggering calcium release and supporting early embryonic development
Deciphering the role of ergosterol and sphingolipids in the antifungal mode of action of rhamnolipids on Sclerotiniaceae.
No full textInternational audienceRhamnolipids (RLs) are natural glycolipids very promising to reduce the use of pesticides to protect crops. They have efficient antifungal properties against Sclerotiniaceae fungi. They are membranotropic compounds permeabilizing fungal cells. We have previously proposed that a lower ergosterol amount could be linked to a lower antifungal sensitivity. The main objective of this paper was to gain insights into the role of plasma membrane lipids in the antifungal mode of action of RLs on Sclerotiniaceae. We obtained ergosterol biosynthesis pathway mutants of Botrytis cinerea and evaluated their sensitivity to RLs. We also analyzed the sphingolipid contents of B. cinerea and S. sclerotiorum and assessed their involvement by a pharmacological approach. We confirm here that a decrease of the ergosterol content in B. cinerea mutants triggers a lower antimycelial activity of RLs. Cotreatments of both mycelium with the polyene natamycin, which specifically binds to ergosterol, show that the ergosterol role in RL activity involves an access of RLs to this lipid. Conversely, we demonstrate that ceramides and acidic glycosphingolipids could have a protective role against the permeabilization property of RLs. These results demonstrate in vivo the antagonistic role of two major membrane lipids in the mode of action of RLs. They also show that the effective use of RLs as antifungal agents within biocontrol strategies requires consideration of differences in the lipid composition of fungi
Cultures et outils technologiques dans les Départements d'Outre-Mer : créolisation des usages/pratiques/médiations numériques ?
No full textThis special issue seeks to articulate two processes of societal and identity (trans)formation : creolization and the construction of digital culture(s) in the French Overseas Departments. Creolization refers to a dynamic process of cultural, linguistic, and political transformations, shaped by tensions and forms of resistance, particularly those linked to the (post)colonial condition of overseas territories. The mechanisms of creolization are mobilized here to examine how technological developments both reinforce and redirect these transformations. The aim of this issue is both scientific and political : to deepen our understanding of the evolving concept of digital culture and to decenter Western-centric approaches by valuing local knowledge, imaginaries, and forms of resistance without fostering identity withdrawal.Ce numéro thématique propose d'articuler deux processus de (trans)formations sociétales et identitaires, celui de la créolisation et celui de la construction de la/des culture/s numérique/s dans les Départements d'Outre-Mer. La créolisation désigne un processus dynamique de transformations culturelles, linguistiques et politiques, marqué par des tensions et des résistances, notamment liées à la situation (post)coloniale des Outre-mer. Les mécanismes constituant la créolisation sont alors repris pour comprendre la manière dont les arrivées technologiques renforcent et détournent ces transformations. L'enjeu de ce numéro est scientifique et politique. Nous cherchons à mieux comprendre la transformation du concept de culture numérique par la créolisation, et décentrer les approches occidentalo-centrées en valorisant les savoirs, les imaginaires et les résistances sans tomber dans le repli identitaire
Nécrose rétinienne aiguë à HVS2 traitée par amenamevir
No full textInternational audienceLa nécrose rétinienne aiguë (ARN) se définit comme une rétinite nécrosante périphérique évoluant vers le pôle postérieur, associée à une artérite rétinienne et à une réaction inflammatoire marquée du vitré et de la chambre antérieure [1]. Ses principales étiologies sont les infections à virus herpès : virus de l’herpès simplex (HSV-1, HSV-2), virus de la varicelle-zona (VZV), plus rarement cytomégalovirus (CMV) et exceptionnellement virus d’Epstein-Barr (EBV). L’identification de l’agent pathogène repose sur l’analyse par PCR d’un prélèvement de chambre antérieure ou de vitré
Effects of Microplastics and Nanoplastics on the Kidneys
No full textInternational audiencePlastics are hydrophobic carbon polymers with a half-life of approximately 500 years. The widespread production and environmental accumulation of plastics pose significant toxicity concerns. Humans are routinely exposed to micro- and nanoplastics (MNPs), which can enter rate the bloodstream and reach various organs, including the kidneys. Here, we review research on nephrotoxic effects of plastics and the underlying mechanisms. The results of several studies of kidneys in mammals and kidney cells from humans suggest that MNPs induce renal toxicity. Although the underlying mechanisms remain to be characterized in detail, the current body of evidence suggests that MNPs promote the production of reactive oxygen species and thus trigger local (renal) and systemic inflammatory responses. These processes enhance cytotoxicity and may drive MNP-induced kidney damage. This toxicity results in histopathological changes in renal tissues (including glomerular and tubular damage and fibrosis) and modifications in key biomarkers of renal function (such as the glomerular filtration rate, albuminuria, and the blood urea nitrogen level). Moreover, MNPs have been shown to induce cardiovascular damage, which may contribute to the progression of chronic kidney disease (CKD) - potentially via the activation of aryl hydrocarbon receptors. Notably, the nephrotoxic effects of MNPs appear to be exacerbated by co-exposure to other environmental contaminants and uremic toxins. CKD can impair the kidneys' ability to eliminate MNP. Furthermore, dialyzed patients are substantially exposed to MNPs during dialysis sessions, which potentially compounds their vulnerability. With a view to better understanding the effects of MNPs on renal health and the impact of CKD and dialysis on levels of exposure to plastics, further studies are essential
The Doctor of Sicca Veneria: Caelius Aurelianus and His Geographical, Social and Cultural Milieu
No full textInternational audienc
P0239 Acceptability of intestinal ultrasound for the follow-up of inflammatory bowel disease: national survey of French patients
No full textInternational audienceBackground Intestinal ultrasound (IUS) is a non-invasive, real-time tool that is increasingly used for inflammatory bowel disease (IBD) monitoring. While its diagnostic accuracy is well documented, patient acceptability remains a major determinant of its integration into routine practice. Methods A cross-sectional online survey of 40 questions was distributed to members of the French association of patients (AFA) with Crohn’s disease (CD) or ulcerative colitis (UC) between June and August 2025. The questionnaire asked about clinical characteristics, lived experience with IUS, and preferences for colonoscopy, entero-MRI, and fecal calprotectin. The acceptability and obstacles to performing perineal ultrasound were also evaluated. Quantitative data were analyzed descriptively, and free responses were qualitatively analyzed. Results Of the 926 respondents (CD, 56% and UC, 41%; mean age: 43 years; 76% women). Ileal (L1, 47%) and rectal (E1, 34%) involvement were the most frequent locations in CD and UC, respectively. 302 (33%) had already benefited from an IUS for the follow-up of their IBD. While 95% felt the duration was appropriate, only 10% felt the exam was uncomfortable/very uncomfortable, 64% reported no pain, and 81% reported no psychological discomfort. Regarding overall acceptability, 87% of patients would accept the IUS at each consultation. Compared to other modalities: 55% consistently preferred IUS to colonoscopy, and 37% in some cases. 48% consistently preferred IUS to entero-MRI, and 26% in some cases. 22% preferred IUS to fecal calprotectin, the latter being perceived as complementary. While the results were considered “very clearly explained” by 61%, the lack of information (51%) and the perceived performance of the IUS were the main obstacles to the implementation of the IUS. Respectively, 47%, 21% and 16% of patients considered IUS to be less effective than colonoscopy, MRI or calprotectin. Regarding perineal ultrasound, only 36 patients (3.8% had already benefited from it). Almost half of them found it uncomfortable, with psychological discomfort in a third. The qualitative analysis (n = 164) highlighted three main themes: (1) IUS is experienced as a welcome and minimally invasive alternative, (2) doubts exist regarding diagnostic reliability compared to standards, (3) patients deplore disparities in access and a need for training/institutional recognition. Conclusion This large national survey demonstrates high acceptability of IUS among IBD patients in France, underscoring its potential as a key tool for routine follow-up. To optimize its integration into clinical practice, concerns about reliability and access must be addressed through improved communication, standardized training, and stronger institutional support References: The Patient Experience with Point-of-Care Intestinal Ultrasound for Inflammatory Bowel Disease Monitoring: A Multicenter Study. Emily Gore PMID: 40968300 DOI: 10.1007/s10620-025-09390-4 Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion. Cathy Lu, Bram Verstockt PMID: 41235810 DOI : 10.1111/apt.70449 Conflict of interest: Dr. Mclellan, Paul: boards for Abbviet and Johson audrey, Malet: No conflict of interest catherine, reenaers: No conflict of interest Restellini, Sophie: Speaker and/or advisory board member for: AbbVie, Janssen, Takeda, Bristol Myers Squibb, Sandoz, Vifor, Dr Falk, iQone, Lilly, Ferring and UCB Wils, Pauline: fees abbvie celltrion Yzet, Clara: No conflict of interest deborah, hassid: No conflict of interest Venezia, Franck: fees amgen abbvie takeda Aygalenq, Philippe: fees abbvie takeda Lagier, Emmanuel: No conflict of interest Buisson, Anne: No conflict of interest Fumery, Mathurin: Grant: Pfizer Personal Fees: Abbvie, Janssen, Takeda, MSD, Biogen, Amgen, Sandoz, Fresenius, Gilead, Celgene, Galapagos, Mylan, Tillots, Ferring, Pfizer, Hospira, CTMA, Boehringer, Lilly, Arena Non-financial Support: Abbvie, Janssen, Takeda, MSD, Galapagos, Ferring, Pfize
Autonomie de la volonté et choix du juge
No full textInternational audienceVersion écrite de la contribution au colloque sur l'actualité de la pensée d'Emmanuel Gounot, l'article analyse cette pensée dans le domaine du contentieux international judiciaire et arbitral