Portail HAL de l'Université Picardie Jules Verne
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De part et d'autre d'une ligne de séparation : le cas de la « zone morte » à Chypre
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Contrats courts et longues carrières. Penser les transformations de l’emploi dans la dynamique des parcours
No full textInternational audienceLes professions culturelles et touristiques connaissent des évolutions dans les caractéristiques de leurs emplois : contrats courts et travail sous régime de l’indépendance gagnent en importance, interrogeant, ici comme dans d’autres secteurs, la norme de l’emploi salarié stable. Véritables défis à l’objectivation statistique, ces transformations interrogent de front les modalités de vieillissement et de maintien dans l’activité tout au long de la vie professionnelle. Deux perspectives croisées éclairent les apports d’une analyse de la discontinuité de l’emploi dans les termes du parcours d’emploi ou de la carrière : d’un côté, la manière dont les organisations employeuses intègrent les questions de continuité dans leurs politiques de l’emploi, de l’autre la façon dont les situations d’emploi font l’objet d’agencements et d’usages sociaux évolutifs au fil de la carrière
Should We Make Influenza and SARS-CoV-19 Vaccinations Mandatory in Medicalized Nursing Homes? An Opinion Survey of French Health Care Professionals.
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A transposase-derived gene required for human brain development
No full textInternational audienceVertebrate brain development is associated with prominent neuronal cell death and DNA breaks, but their causes and functions are not well understood. DNA transposable elements could contribute to somatic genome rearrangements; however, their contributions to brain development are largely unknown. PiggyBac transposable element derived 5 (PGBD5) is an evolutionarily conserved vertebrate DNA transposase–derived gene with DNA remodeling activities in human cells. Here, we show that PGBD5 contributes to normal brain development in mice and humans, and its deficiency causes disorder of intellectual disability, movement disorders, and epilepsy. In mice, Pgbd5 is required for the developmental induction of postmitotic DNA breaks and recurrent somatic brain genome rearrangements. In the cerebral cortex, loss of Pgbd5 leads to aberrant neuronal gene expression, including of specific types of glutamatergic neurons, which partly explains the features of PGBD5 deficiency in humans. Thus, PGBD5 is a transposase-derived gene required for brain development in mammals
The frequency of binge-like ethanol exposure bidirectionally regulates hippocampal mGlu-LTD via synaptic mechanisms and this effect is reversed by minocycline
No full textInternational audienceAlcohol addiction may begin in young adults through binge drinking (BD) with its frequency as key criterion. In rodents, BD impairs memory and hippocampal synaptic plasticity on the short term and induced neuroinflammation. Memory impairments may persist into adulthood, whereas long-lasting disturbances in hippocampus synaptic plasticity have not been documented. Moreover, the impact of BD frequency on such disturbances and the potential of anti-inflammatory agents to reverse BD-induced alterations remain unclear. Using hippocampal slices from male rats subjected to eight binge-like episodes delivered at high (HF) or low (LF) frequency during adolescence, we found that alterations in group I metabotropic long-term depression (mGlu1/5-LTD) were related to binge-like exposure frequency, with HF reducing mGlu1/5-LTD and intriguingly, LF increasing it. Inhibiting mTORC1 with rapamycin partially corrected LF and HF effects, without alteration of ribosomal protein S6 phosphorylation, a protein downstream of mTORC1, after LF and, a decrease of rp-S6235/236 after HF. Moreover, LF decreased presynaptic GABA vesicular transporter and bicuculline replicated the increased mGlu1/5-LTD after LF. Additionally, N-methyl-D-aspartate receptor-dependent LTD was transiently reduced after HF or LF and rescued with a GluN2B antagonist. Finally, the anti-inflammatory agent, minocycline, administered after the ethanol exposure, reversed all synaptic plasticity alterations. We concluded that bidirectional alteration in mGlu1/5-LTD is a hallmark of ethanol binge exposure frequency, involving pre- and postsynaptic mechanisms. Targeting GluN2B and using anti-inflammatory agents offers promising therapeutic strategies to mitigate the synaptic effects of BD. Our findings highlight the frequency of ethanol exposure as a key determinant of neuronal impact
Mycoplasma encephalitis, incomplete Kawasaki disease and MERS, a new association? Short communication
No full textInternational audienceBackground: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is an uncommon clinico-radiological entity, mostly described in children in association with viral or atypical bacterial infections. Mycoplasma pneumoniae (MP) is a rare but recognized trigger. Kawasaki disease (KD) may also present with neurological involvement.Observation and discussion: We report the case of a 14-year-old boy with acute encephalopathy, Mycoplasma pneumoniae infection, and features of incomplete KD. Brain MRI showed a reversible lesion in the splenium of the corpus callosum consistent with MERS. The patient developed mucocutaneous signs and transient coronary artery dilatation. He improved with antibiotic and anti-inflammatory therapy.Conclusion: This case highlights a rare overlap between MERS, Mycoplasma pneumoniae, and incomplete KD, suggesting shared inflammatory pathways. Clinicians should consider this association when encountering pediatric encephalopathy with systemic inflammatory features
« C’est comme si j’étais sortie de l’humanité ». Deuil, argile et art-thérapie
No full textInternational audienceContext and Guiding QuestionThis article examines clay-based art therapy as a therapeutic response for war widows navigating the twin burdens of post-traumatic stress disorder (PTSD) and complicated grief. Within programs led by the Lebanese Association of Victims of Terrorism (AVT-L) and partner NGOs (Dignity beyond borders, AVVAT et Solidarité Défense), the authors observe that bereavement following violent, often public deaths fragment's identity, freezes symbolization, and constrains speech. The guiding question is explicit: How does art therapy with clay help military widows reconstruct identity after PTSD and complex grief? The working hypothesis is that clay, as a sensori-motor, group-based, and transcultural medium, converts the “unspeakable” into a manipulable form, enabling affect regulation, meaning-making, and the repair of familial bonds.Program and MethodsThe documented program has been implemented since 2019 and, to date, has served 125 widows. The current cohort comprises 25 adult widows from five countries (France, Lebanon, the United States, the United Kingdom, Jordan). The intervention begins with six, two-hour group sessions, delivered in two subgroups (12 and 13 participants) and co-facilitated by a trilingual art therapist (Arabic/French/English) and a trilingual clinical psychologist; no interpreters are used to preserve continuity and nuance. Depending on clinical indication or participant request, widows are then offered individual follow-up (two sessions per month for four months) to consolidate gains. The clinical frame is precisely described (group composition, session choreography, safety and ethics), and outcomes are illustrated through a central case vignette (Mme M.). Across the program, emphasis falls on sensorially, group dynamics, and the transcultural status of clay as a “universal” medium that helps participants traverse emotional and linguistic barriers.Theoretical RationaleGrounded in trauma-informed practice and informed by group and art-therapy theory, clay's haptic engagement activates perception – action loops that reduce hyperarousal and allow pre-symbolic contents to take shareable form. In group settings, co-regulation (through shared rhythms of modeling, posture, and silence) enhances affect tolerance and supports mentalization; peers act as mirrors, and the “language of gesture” precedes speech. In grief work, the medium facilitates negotiation between presence and absence, loosens rigid identifications, and supports flexible, continuing bonds. Its accessibility and reversibility provide psychological safety, enabling exploration without fear of failure. A clinical vignette illustrates the psychic and sensorimotor mechanisms activated during a clay-based art therapy workshop, highlighting the transition from emotional disorganization to symbolization and identity reconstruction.Clinical FindingsObservations align with the literature: group clay work reduces avoidance, increases affect tolerance, and restores narrative coherence. Participants move from frozen or chaotic states to sequences of doing–feeling–thinking, in which tactile exploration and form-making unlock emotions that previously resisted verbalization. Families begin to re-open dialogue, with spillover effects such as mother–child co-creation scenarios that seed new micro-rituals of connection at home. Overall, widows report a shift from passive suffering to agentive engagement; “I do/I transform” which is a precursor to identity reconstruction.Mechanisms of ChangeClay modulates arousal through sensory–motor regulation: kinesthetic feedback (pressing, smoothing, reshaping) soothes physiology and widens tolerance for difficult affects. Emergent forms carry experience “from trace to sign to symbol,” making preverbal material communicable. In groups, shared tempos and gestures foster embodied empathy and peer mirroring, with co-modeling felt as solidarity rather than intrusion. Its transcultural familiarity bypasses language barriers and lowers translation burdens in multilingual cohorts. Reversibility (forms can be remade) provides psychological safety, reducing perfectionism and enabling iterative exploration. Together, these processes support identity reweaving, shifting immobilized grief toward flexible continuing bonds and renewed roles in family, work, and community.Countertransference and Clinical StanceThe authors explicitly reflect on countertransference: working with widows mobilizes compassion, protective impulses, and, at times, revolt against the image of the “broken” woman. Recognizing these forces, therapists prioritize a “sufficiently close” yet non-intrusive stance, resisting premature reassurance. The ethic of time is central: do not rush speech; allow creation to lead to words. This reflective posture secures the frame and protects the agentivity of widows, whose pace and choices must remain primary.Limitations and Practical ConstraintsThe article notes constraints on scalability: multi-country delivery entails travel and logistics costs; language remains a consideration even when the medium is largely nonverbal; and clinicians ideally should be trilingual to maintain subtlety without interpreters. Program design currently includes separate groups (single mothers, bereaved children, mother–child dyads) aligned by language and nationality to ensure safety and cultural fit. These pragmatic limits argue for modular expansion rather than “one size fits all” scaling.Dans le cadre des actions menées par l’Association Libanaise des Victimes du Terrorisme et ses partenaires (Dignity beyond borders, AVVAT et Solidarité Défense), cet article présente l’art-thérapie par l’argile comme une approche pour accompagner des veuves de militaires confrontées à un deuil complexe et aux séquelles d’un stress post-traumatique. Ces femmes, issues de contextes culturels variés, font face à des ruptures psychiques et relationnelles profondes auxquelles un dispositif créatif, sensoriel et groupal peut offrir une réponse clinique adaptée. L’objectif est d’examiner comment l’art-thérapie par l’argile, média sensoriel et transculturel, facilite l’expression des émotions, la symbolisation du traumatisme et la reconstruction identitaire et familiale. Un dispositif de six ateliers collectifs, conduits par une art-thérapeute trilingue (arabe, français, anglais), a été mis en place auprès de 25 veuves originaires de cinq pays (France, Liban, États-Unis, Royaume-Uni, Jordanie). Elles sont adressées par les psychologues des associations partenaires dans chacun de leurs pays respectifs, selon des critères cliniques liés au deuil traumatique. Après évaluation clinique, un suivi individuel complémentaire de deux séances mensuelles sur quatre mois a pu être proposé. À ce jour, 125 veuves ont bénéficié de ce dispositif, encadré par des règles de sécurité, d’éthique et de consentement éclairé. Les observations cliniques confirment les effets décrits dans la littérature : l’argile agit comme un médiateur puissant d’extériorisation et de transformation des traces traumatiques, favorisant la continuité psychique et la reprise d’un récit de soi. On note une diminution des conduites d’évitement, une meilleure régulation émotionnelle et des signes de réparation relationnelle. L’art-thérapie par l’argile apparaît ainsi comme un cadre contenant, universel et transculturel, convertissant l’indicible en formes partageables. La dimension groupale amplifie les effets de miroir et de soutien mutuel. Cette approche ouvre des perspectives vers de nouveaux modes familiaux alliant création et narration, afin de renforcer la reconstruction relationnelle et la transmission apaisée des vécus traumatiques
French perspectives on the 2025 ESC/EACTS guidelines for valvular heart disease
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Ethical and methodological insights: an interdisciplinary study of letters written by Jews interned in the Drancy camp during the Second World War
No full textInternational audienceThis article examines the methodological and ethical challenges raised by an interdisciplinary study that investigates the functions of correspondence in contexts of wartime isolation, using as its paradigm the letters written by individuals interned as Jews in the Drancy camp during the Second World War, within the context of the Shoah. Bringing together psychology and contemporary history, the project seeks to illuminate the complex human issues related to a major historical and socio-political event – the Second World War. The article outlines a multi-stage qualitative methodology combining different levels of analysis. It demonstrates how engagement with such historically and emotionally charged archives requires a revision of conventional research and theoretical frameworks. Interdisciplinary dialogue is presented as a safeguard against over-interpretation and anachronistic readings. Finally, the article addresses the ethical tensions inherent in analysing intimate Shoah-related documents, underscoring the need for reflexivity, and the collective processing of emotional responses
"En réseau, Histoire, Anarchie et Droit" dans "Au Tours du Droit" sur Radio Béton
No full text[En ligne] URL : https://podcast-radiobeton.com/au-tours-du-droit (58min40)Présentation du réseau de recherche EnRHAD (En Réseau, Histoire, Anarchie et Droit) par ces créateurs (Alexandre Mimouni, Louis Terracol et Romain Broussais) interrogés par Colombine Madelaine, animatrice de l'émission "Au Tours du droit" sur "Radio Béton" : https://podcast-radiobeton.com/au-tours-du-droi