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STATE-FEEDBACK STABILIZATION OF 2 × 2 HYPERBOLIC SYSTEMS WITH DISTRIBUTED ACTUATION
No full textThis paper addresses the stabilization of a 2 × 2 system of heterodirectional linear first-order hyperbolic partial differential equations using distributed in-domain actuation. By applying a backstepping Volterra transformation, the PDE system is reformulated as an integral difference equation. We then propose a controller with an auto-regressive structure, formulated as a distributed delayed feedback involving both the system state and the control input. The controller gains are computed by solving a set of Fredholm integral equations, whose solvability is ensured via an approximate controllability condition. The proposed methodology is further extended to a mixed actuation setting, in which the same control input also acts at one boundary of the domain. Numerical simulations are provided to illustrate and validate the theoretical results
Challenges in defining the primary outcome for postpartum hemorrhage
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Multi-filter diamond array time-of-flight particle detector in laser–plasma experiments
No full textInternational audienceRecent advances in ion diagnostics for laser-induced plasma experiments have improved system design and data analysis. Measuring charged particle emissions from laser-irradiated targets provides valuable insights into laser–matter interactions. Among real-time diagnostics, Time-of-Flight (TOF) detectors are reliable systems for analyzing particle beam properties such as kinetic energy and shot-to-shot reproducibility. Diamond-based detectors are ideal for TOF measurements due to their fast response time, radiation hardness, and low leakage current. However, TOF detectors lack particle discrimination. To overcome this, a Multi Filter Diamond Array (MFDA) was developed using six nominally identical single crystal diamond detectors paired with aluminum foils of different thicknesses to exploit particle stopping power differences. The MFDA was tested at the Prague Asterix Laser System during an experimental campaign in the framework of the FUSION project, and data analysis was performed. A cross-validation with other diagnostics, including a Thomson Parabola Spectrometer and CR-39 detectors, is also presented.</jats:p
Precipitation pathway in oxide dispersion-strengthened steels: From metastable precursors to pyrochlore
No full textInternational audienceOxide Dispersion Strengthened (ODS) materials are promising candidates for applications as core components for the next generation of nuclear power plants, including both GEN IV reactors and fusion reactors. These materials are characterized by a fine distribution of nano-oxides, which imparts excellent creep resistance. In this paper, a comprehensive characterization of the nano-oxides is proposed using Cs-corrected transmission electron microscopy. We show that three types of oxides exist within the ferritic matrix: nanoclusters with a structure identical to that of the matrix, pyrochlore-structured nano-oxides, and, for the first time, intermediate-sized nano-oxides exhibiting a structure in the process of transforming into the pyrochlore phase. We conclude that the formation of nano-oxides follows a precipitation sequence in which metastable nanoclusters act as precursors to the pyrochlore-like nano-oxides. Understanding this pathway is crucial, as it not only enables control over oxide distribution (in terms of size and density), but also provides insights into the formation of interface structure, which governs point defect and helium trapping. Moreover, it contributes to understanding the irradiation resistance of nano-oxides, since nanoclusters may be more resistant than pyrochlores, or vice versa
A study of the integration by non-homologous end joining (NHEJ) of a trackable DNA cassette with randomly-generated borders into Yarrowia lipolytica genome sheds light on exogenous DNA extremities degradation and confirms the potential of NHEJ-mediated integration for the design of genome-scale insertional mutant libraries in non-conventional yeasts
No full textIn order to analyse the fate of an exogenous DNA introduced into Yarrowia lipolytica cells, the authors designed a series of trackable DNA cassettes with randomly-generated borders able to integrate by NHEJ into the yeast genome. NGS sequencing of large libraries of insertional mutants provided for the first time data on the extent of degradation suffered by an exogenous DNA in Y. lipolytica cells, depending on its size and type of extremities. For all types of fragments, degradation prior to integration very rarely exceeded a dozen nucleotides. Significant differences were observed in the percentage of non-degraded fragments depending on the type of extremities: degradation was the lowest for blunt ends, it was slightly higher for 5' overhangs and markedly higher for 3' overhangs. This study also brought confirmation of the randomness and high coverage of NHEJ-mediated integration, providing a new tool for NHEJ-seq (Tn-seq-like) high-throughput analysis of gene fitness in Y. lipolytica.</div
Observation of the decay
No full textInternational audienceThe first observation of the decay is reported using proton-proton collision data recorded with the LHCb detector corresponding to an integrated luminosity of . The decay mode is observed for the first time, with a significance of . Its branching fraction is measured relative to the decay mode \begin{align*} \frac{\cal{BF}(χ_{c1}(3872)\rightarrow J\mskip -3mu/\mskip -2muψμ^+μ^-)}{\cal{BF}(χ_{c1}(3872)\rightarrow J\mskip -3mu/\mskip -2muψπ^+π^-)} = \left(1.64\pm 0.32\pm 0.05\right)\times10^{-3}, \end{align*} where the first uncertainty includes both statistical contributions and systematic contributions which are uncorrelated between data-taking periods, and the second represents the systematic contributions that are correlated between data-taking periods
Search for heavy long-lived charged particles with level-1 trigger scouting data from proton-proton collisions at = 13.6 TeV
No full textInternational audienceA search for heavy long-lived charged particles at the LHC is presented. Particles interacting with the CMS muon detector across several bunch crossings are searched for using a data sample of proton-proton collisions at = 13.6 TeV collected with the CMS detector in 2024, corresponding to an integrated luminosity of 3.7 fb. This is the first search relying on the novel level-1 trigger scouting data set collected without any trigger selection, allowing correlations between bunch crossings to be analyzed. The results are interpreted as upper limits on the cross sections of several benchmark processes with pair production of heavy long-lived charged particles. Upper limits on the fiducial cross section of a heavy long-lived charged particle with 500 GeV and 0.83 are also set in different ranges of . This analysis is a crucial proof of concept for the level-1 trigger data scouting system and complements existing searches for heavy long-lived charged particles by extending the sensitivity to lower values
Tissue from gender-affirming genital surgery as a model for human penile physiology research: promise, ethics, and scientific duty. A gift from transgender women to the science of male sexuality
No full textInternational audienceUnderstanding human erectile tissue and tunical remodeling remains one of the enduring challenges in sexual medicine. Despite the high prevalence of erectile dysfunction (ED), no major therapeutic innovation has emerged since the introduction of phosphodiesterase type 5 (PDE5) inhibitors more than two decades ago. The fundamental mechanisms underlying erectile function remain incompletely understood, and many recent insights still rely on animal models to explore and validate emerging physiological hypotheses—even in leading high-impact journals.1 Access to functional human penile tissue remains rare. Most studies have analyzed samples obtained during penile implant procedures, typically performed in cases of severe ED refractory to both pharmacological and mechanical therapies, where structural preservation of the corpora cavernosa is often compromised. Similarly, Peyronie’s disease research is constrained by limited access to well-characterized human tunical tissue, and robust human tunica albuginea models remain scarce.Accordingly, there is an urgent need for new, well-characterized human models to study penile tissue structure and function
A Case of Mediastinal Adenopathy and Clinically Suspected Myocarditis
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