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Habemus Normam : de la domestication à l’authenticité normée dans The YoungPope et The New Pope
No full textInternational audienceCette communication propose une analyse critique du leadership contemporain à partir de deux sériesde Paolo Sorrentino dont les figures contrastées des papes Pie XIII et de Jean-Paul III permettentd’examiner la temporalité de la subjectivation normative en quatre phases successives à savoir,domestication, autodomestication, isomorphisme personnel et authenticité normée. Certes, malgrédes styles opposés, l’autorité charismatique d’un côté et la vulnérabilité empathique de l’autre, lesdeux pontificats fictifs convergent vers des formes de contrôle de la subjectivité par la normativitécomportementale. Notre méthodologie met en correspondance motifs attendus et motifs observés touten testant des motifs rivaux et des cas négatifs. Cette communication propose un dispositifpédagogique simple qui mesure les acquis conceptuels et la capacité critique. De fait, les sériestélévisées constituent des laboratoires réflexifs pour apprendre à diagnostiquer la subjectivationnormative et à débattre des limites d’un leadership dit vulnérable. Dans les deux saisons, les procédésd’intériorisation normative convergent, mais néanmoins par des mécanismes affectifs et rituelsdistincts
On inverse tout : la ludopédagogie comme porte d'entrée aux pratiques ludiques
No full textNational audienceLes dispositifs ludopédagogiques sont souvent conçus grâce à l'importante littératie ludique des animateurs. Nous parlons en effet d'amener du ludique dans les activités pédagogiques. Et si la ludopédagogie était également une porte d'entrée pour promouvoir indirectement les pratiques ludiques de loisirs en permettant aux participants de découvrir le monde du jeu ? C'est le sujet de ce retour d'expérience. Nous abordons la découverte du wargaming et du jeu de rôle sur table à l'université, non pas pour que les étudiants montent en compétences disciplinaires mais pour faire découvrir ces activités ludiques peu connues du grand public. Ce retour d'expérience explore donc une approche inverse de la logique d'implémentation des pratiques ludiques dans l'apprentissage en montrant que la ludopédagogie est également une source de promotion des activités de loisirs. En effet, le déploiement de jeux en formation mène un développement de la littératie ludique des apprenants
How is the carbon use efficiency of microbial communities distributed within the soil pore network
No full textInternational audienceSoils play a key role in mitigating global warming due to their capacity to sequester CO₂, a process likely impacted by the efficiency with which microbial communities transform organic matter into biomass. The activity of microbes is affected by the conditions they find themselves in (moisture, oxygen, etc.). Soils are characterized by a network of pores of different sizes, which create a variety of microenvironments that can influence resource availability, microbial activity and soil C dynamics. However, the influence of conditions at the porescale on microbial carbon use efficiency remains poorly quantified. In this study, we conducted short-term incubations using a mixture of 13 C-labelled compounds to assess the carbon use efficiency of microbial communities residing in pores with maximum neck diameters between 15 and 30 μm and between 75 and 200 μm. The study was carried out in an agricultural soil (Eutric Cambisol) under three different management practices and a grassland (Sandy Cambisol) in order to have a range of pore structures, C contents, pH and different microbial communities. Our findings show that microbial mineralization of added substrate was higher in the large pores but that the carbon utilization efficiency was lower. The differences across pore sizes were likely due to the different constraints at the microenvironment scale (moisture, predation, available space, substrate abundance, etc.). These results suggest that microbes adopt distinct carbon processing strategies and functional roles, depending on pore size
Electrical resistivity tomography for geohazard assessment in West Lombok’s alluvial plain
No full textInternational audienceElectrical resistivity tomography (ERT) is widely used for mapping subsurface conditions and is very useful for assessing geohazards. Variations in resistivity can suggest anomalies that can be linked to fault zones, or sediment layering that specifies a particular body, such as sediment-filled basins, or loose soils that are prone to earthquake amplification, liquefaction, and ground failure. This study examines two alluvial plains in West Lombok: Mataram city (the densely populated capital) and Tanjung (a coastal tourist area). Alluvial plains are especially vulnerable to geohazards because their loose, water-saturated sediments intensify seismic shaking and raise liquefaction risks during earthquakes. Our ERT models show a consistent subsurface structure: sand-dominated layers extending beyond 30 meters, topped by pumicerich volcanic deposits. In some areas, shallow groundwater ( < 2 meters deep) was detected, further increasing liquefaction potential. Specific resistivity patterns match known liquefaction features, which suggest historical liquefaction had occurred in Mataram. These results emphasize the importance of combining ERT with direct methods, such as trenching and boreholes, to verify subsurface models and refine hazard assessments
Phase I(b) study evaluating the safety and efficacy of intratumoral agonistic anti-CD40 (selicrelumab) in combination with anti-PD-L1 (atezolizumab) in patients with refractory or relapsed B-cell lymphoma (ITSELF trial)
No full textInternational audienceBACKGROUND: The efficacy of immune checkpoint blockade therapy requires pre-existing antitumor immunity. Defective antigen presentation during the priming phase can reduce the generation of tumor-specific T cells, which are necessary during the effector phase and subsequent tumor elimination. We propose an in situ immunization strategy to enhance direct tumor antigen presentation by the lymphoma B cells via cluster of differentiation (CD)40 stimulation in order to sensitize B-cell lymphoma to programmed cell death protein 1/programmed death-ligand 1 (PD-L1) blockade therapy.MATERIALS AND METHODS: ITSELF is a multicenter, open-label, dose-escalation phase Ib trial of intratumoral selicrelumab, an agonistic anti-CD40 monoclonal antibody, every 3 weeks for three cycles in combination with intravenous atezolizumab, an antagonistic anti-PD-L1 monoclonal antibody, at 1200 mg every 3 weeks for three cycles followed by intravenous atezolizumab monotherapy for a total of 12 months in patients with relapsed/refractory B-cell lymphoma. RESULTS: Two patients with follicular lymphoma and two patients with diffuse large B-cell lymphoma were enrolled at the first dose level of 1 mg intratumoral selicrelumab. Those four patients received the three cycles of intratumoral selicrelumab in combination with intravenous atezolizumab. Patients did not develop severe adverse events related to the drugs or the intratumoral procedures. No or low-grade adverse events were reported and related to atezolizumab or to the combination therapy. All patients discontinued the treatment because of disease progression according to Lugano 2014 criteria on their first positron emission tomography scan disease evaluation at the end of cycle 3 (week 9). The trial was stopped prematurely because of issues with selicrelumab drug supply.CONCLUSION: The combination of 1 mg of intratumoral selicrelumab and 1200 mg of intravenous atezolizumab was safe for patients with relapsed/refractory B-cell lymphoma and led to some tumor stabilization or regression, although it did not result in objective tumor response
Ridge-penalised spectral least-squares estimation for point processes
No full textPenalised estimation methods for point processes usually rely on a large amount of independent repetitions for cross-validation purposes. However, in the case of a single realisation of the process, existing cross-validation methods may be impractical depending on the chosen model. To overcome this issue, this paper presents a Ridge-penalised spectral least-squares estimation method for second-order stationary point processes. This is achieved through two novel approaches: a p-thinning-based cross-validation method to tune the penalisation parameter, relying on the spectral representation of the process; and the introduction of a spectral least-squares contrast based around the asymptotic properties of the periodogram of the sample. The proposed method is then illustrated by a simulation study on linear Hawkes processes in the context of parametric estimation, highlighting its performances against more traditional approaches, specifically when working with short observation windows
Enseigner la culture de la sécurité avec la simulation aéronautique : cas d’usages en IAE et IUT - Partie 2
No full textInternational audienceDans le cadre de travaux communs, menés fin 2024 et début 2025, sur le déploiement pédagogique de plateformes de simulation aéronautique à l’IAE Paris-Est (Université Paris-Est Créteil) et l’IUT de Colmar (Université Haute-Alsace), nous avons questionné les apprenants sur les niveaux 1 et 2 du modèle d’évaluation des formations de Kirkpatrick & Kirkpatrick (2016). De plus, nous avons également mesuré l’acquisition des connaissances au travers d’un test identique en amont et en aval de chaque enseignement. Ce poster rend compte des premiers résultats bruts obtenus
Advanced insights into the biodeterioration and conservation strategies of cultural heritage: A review
No full textInternational audienceStone monuments, which have immense historical, artistic, and cultural significance, are vulnerable to environmental factors and microbial colonization, leading to irreversible material loss and posing major challenges for cultural heritage conservation worldwide. Microbial colonization of stone monuments is highly influenced by environmental factors causing subsequently stone degradation through acid production, mineral dissolution, and mechanical stress. Despite numerous studies, a critical synthesis linking microbial mechanisms with conservation strategies remains limited. This review provides a comprehensive analysis of both traditional and modern conservation techniques to prevent, limit or repair the negative effects caused by microorganisms. Conventional biocidal treatments, though effective initially, raise concerns regarding long-term performance and ecological safety, prompting research into sustainable alternatives such as nanoparticles, polymer-based coatings, and natural antimicrobial agents. Emerging approaches, including the use of nanoparticles, polymer-based protective coatings, and natural antimicrobial agents such as essential oils, are reviewed in detail. Special emphasis focuses on evaluating the efficacy, durability, and environmental impact of these interventions. This review highlights the need for eco-compatible conservation solutions that balance antimicrobial efficiency with material durability and environmental safety