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Application of the new Check-Sort-Push mechanism in the iRPC subsystem for the CMS Phase-2 upgrade
No full textInternational audienceBackend electronics (BEE) commonly employ a highspeed link to provide both fast and slow control to frontend electronics (FEE). In addition, the backend is responsible for trigger preprocessing and data readout. Typically, this high-speed link is shared by many frontend channels. Under such conditions, the processing time in the BEE for channels with lower readout priority varies significantly, especially in scenarios with high hit rate. This variability results in unpredictable or even unacceptable processing latency for demultiplexing and trigger preprocessing, even when zero-suppression and multiplexing are applied in FEE before data transmission. This paper addresses these issues through emulation study and proposes the Check-Sort-Push (CSP) mechanism as a solution. The necessity and advantages of this proposal are demonstrated using simulation andemulation under high hit rate conditions. An implementation in firmware is presented. Finally, the application of the CSP mechanism in the improved Resistive Plate Chamber (iRPC) system for CMS Phase-2 upgrade will be discussed, along with analysis results based on test beam data
Direct transfer to K as a survey of the interaction
No full textInternational audienceThe collapse of the canonical magic number in nuclei with has drawn significant interest as it relates to the emergence of an island of inversion centered on Si and S. In particular, interactions between the orbital -- empty in Si and full in S -- and the neutron orbitals just above and below the gap are expected to be critical in this region, but remain relatively unexplored. In this paper, we expand upon the results of our previous study of the direct transfer reaction K(d,p)K [C. J.~Paxman \textit{et al.}, Phys. Rev. Lett. 134, 162504 (2025)] with the results of the complementary K(d,t)K reaction. Through this study, we present a comprehensive scan of the interaction between the critical orbital and a broad range of neutron orbitals spanning nearly two full shells. We identify several discrepancies between the experimental results and state-of-the-art shell model calculations, which suggest a deficiency of the shell model to fully capture the complex proton configuration mixing in this region, highlighting a significant challenge for single-particle descriptions of the island of inversion
Santé environnementale et transition écologique du système de santé
No full textInternational audienceFace à l’urgence climatique et aux effets de l’environnement sur la santé, la transition écologique du système de santé est devenue un enjeu majeur. Cet ouvrage propose une synthèse structurée et opérationnelle des fondements de la santé environnementale et de leur application au champ sanitaire et médico-social.Il réunit les définitions essentielles des notions clés (santé environnementale, transition écologique, décarbonation des activités…), un état des lieux du cadre juridique, des politiques publiques et des connaissances actuelles (PNSE 4, feuille de route de planification écologique du système de santé), ainsi que des exemples concrets de démarches de transition mises en œuvre dans les établissements de santé et médico-sociaux.Une annexe méthodologique dédiée aux concours administratifs complète l’ouvrage, avec des conseils pratiques et des exemples de sujets.Initialement conçu pour les candidats aux concours d’entrée à l’EHESP, ce livre s’adresse également aux professionnels du système de santé souhaitant intégrer les enjeux environnementaux dans leurs pratiques, leurs décisions et leurs engagements, ainsi qu’à toutes celles et ceux désireux de concilier expertise sanitaire et responsabilité écologique
Segmentation et reconstruction 3D de lignées cellulaires par apprentissage profond à partir des images confocales
No full textInternational audienceCe travail présente un pipeline complet combinant imagerie confocale, segmentation par deep learning et reconstruction 3D réaliste de cellules afin d’améliorer la modélisation radiobiologique en thérapies anticancéreuses utilisant des radioisotopes. En s’appuyant sur nnU-Net et sur une base de données soigneusement prétraitée, la segmentation du noyau et du cytoplasme atteint des performances élevées (Dice > 0,91). Les reconstructions 3D révèlent une forte hétérogénéité morphologique entre lignées cellulaires, incompatible avec des modèles géométriques simplifiés. La base de données obtenue constitue un support clé pour des simulations Monte Carlo avancées (Geant4-DNA), permettant d’affiner l’estimation du RBE et d’améliorer les modèles biophysiques tels que NanOx
Étude interventionnelle longitudinale sur 3 ans de la cohorte Explo'Santé : évolution des scores de compétences psychosociales, de sentiment d'efficacité personnelle, de satisfaction de vie et de littératie en santé de la primaire au collège
No full textInternational audienceIntroduction Childhood and adolescence are decisive life stages during which social and health inequalities emerge and widen. Schools represent a privileged setting for health promotion, particularly through the development of psychosocial resources such as life skills (LS), self-efficacy (SE), life satisfaction (LSa), and health literacy (HL). The Explo’Santé program is a French school-based health promotion intervention that combines structured health education sessions with supportive environments.Methods This longitudinal cohort study followed 744 pupils from 4th grade in primary school to the first year of middle school. LS, SE, LSa, and HL were assessed at six time points across three annual intervention cycles, each including ten weekly school-based health education sessions. Results Linear mixed models showed short-term gains in LS, SE, and LSa during primary school, followed by a marked decline after the transition to middle school, whereas HL increased steadily throughout the 3 years. Girls consistently scored higher than boys but also showed sharper decreases once in 6th grade. Territorial disparities were observed, with some districts showing strong improvements while others consistently lagged. Discussion These findings suggest that the Explo’Santé program supports the development of key psychosocial competencies, but that the transition to middle school represents a critical turning point which challenges their sustainability. By highlighting gendered vulnerabilities and contextual inequalities, this work contributes to understanding how schoolbased health promotion can foster more equitable developmental trajectories.Introduction L'enfance et l'adolescence sont des étapes de vie décisives au cours desquelles les inégalités sociales et de santé émergent et se creusent. L'école représente un milieu privilégié pour la promotion de la santé, notamment par le développement de ressources psychosociales telles que les compétences psychosociales (CPS), le sentiment d'efficacité personnelle (SEP), la satisfaction de vie et la littératie en santé. Le programme Explo’Santé est une intervention française de promotion de la santé en milieu scolaire qui associe des séances structurées d'éducation à la santé à la mise en place d'environnements favorables.Méthodes Cette étude de cohorte longitudinale a suivi 744 élèves du CM1 jusqu'à la classe de 6ème (première année de collège). Les CPS, le SEP, la satisfaction de vie et la littératie en santé ont été évalués à six reprises au cours de trois cycles d'intervention annuels, comprenant chacun dix séances hebdomadaires d'éducation à la santé en classe.Résultats Les modèles linéaires mixtes ont mis en évidence des gains à court terme concernant les CPS, le SEP et la satisfaction de vie durant l'école primaire, suivis d'un déclin marqué après la transition vers le collège, tandis que la littératie en santé a progressé de manière constante tout au long des trois années. Les filles ont systématiquement obtenu des scores supérieurs à ceux des garçons, mais ont également accusé des baisses plus brutales une fois en 6ème. Des disparités territoriales ont été observées : certains quartiers ont affiché de fortes améliorations alors que d'autres sont restés constamment en retrait.Discussion Ces résultats suggèrent que le programme Explo’Santé soutient le développement de compétences psychosociales clés, mais que l'entrée au collège constitue un tournant critique qui met à l'épreuve leur pérennité. En mettant en lumière les vulnérabilités liées au genre et les inégalités contextuelles, ce travail contribue à la compréhension de la manière dont la promotion de la santé en milieu scolaire peut favoriser des trajectoires de développement plus équitables
Evaluating Segmentation Using Betti-1 Topological Metric: Application to Nasal Cavities in the context of airflow simulation
No full textInternational audienc
For the use of exterior form in daily physics, an introduction without coordinate frame
No full textThis is a short introduction of the exterior form formalism focus on its appli-cations in physics and then mostly aimed to physics students. If exterior formsare more than a century old they are unfortunately still seen (and teached) asa high level mathematics object and then little used outside theorical physics.We then focus here on simple examples which occure in daily phiysics. Thereexists already a lot of very good mathematical textbooks and courses on thesubject but the originality of these notes, the physical applications aside, is thatwe keep a completely geometrical approach. As a rule of a game played here wenever use a coordinate frame neither in the definitions nor in the proofs but onlyat the end in order to recover the classical physics equations
Hyperpolypharmacy in patients with chronic kidney disease and its impact on clinical outcomes
No full textInternational audienceHyperpolypharmacy (≥ 10 daily medications) is frequent in patients with chronic kidney disease (CKD), but its impact remains poorly characterized. This study, based on 3,011 non-dialyzed, non-transplant CKD outpatients from the CKD-REIN cohort (eGFR < 60 mL/min/1.73 m2) aimed to describe drug burden and assess associations between hyperpolypharmacy and adverse outcomes. Drug prescription, kidney function, adverse drug reactions (ADRs), hospitalizations, kidney replacement therapy and deaths before KRT were prospectively recorded over five years. Median age was 69 years and mean eGFR was 34 mL/min/1.73 m2. At baseline, 80% of the cohort had polypharmacy (≥ 5 daily medications), and 33% had hyperpolypharmacy. These rates remained stable over time. Diabetes, dyslipidemia, and a history of cardiovascular and respiratory diseases were the main contributors to hyperpolypharmacy status. Hyperpolypharmacy was associated with greater likelihoods of an ADR (hazard ratio (HR) [95% confidence interval (CI)] 1.21 [1.04-1.40]), hospitalization (HR [95%CI] 1.34 [1.18-1.51]) and death before KRT (HR [95%CI] 1.46 [1.17-1.82]). Among patients with eGFR ≥ 30 mL/min/1.73m2, hyperpolypharmacy also raised the risk of KRT initiation (HR [95%CI] 1.46 [1.00-2.13]), but not in those with eGFR < 30 (HR [95%CI] 0.94 [0.78-1.14]). These results identify hyperpolypharmacy as a significant concern in CKD and underscore the importance of regular medication reviews to reduce adverse outcomes
Symmetries of cosmological perturbations: The residual low-multipole ambiguity
No full textInternational audienceIn cosmology, long-wavelength modes are related to large-gauge transformations (LGT), i.e. changes of coordinates that modify the physical geometry of the cosmological patch. These LGTs stand as bona-fide symmetries of cosmological perturbation theory with various applications, from consistency relations constraining cosmological correlators to non-linear conservation laws in the separate-universe approach. In this work, we revisit LGTs and derive two new results. First, we show that the global symmetries already identified in the literature can be extended to local infinite-dimensional symmetries. The associated generators depend on arbitrary functions of time, and generate low-multipole modes that modify the mean curvature energy and the angular momentum of the patch, demonstrating their physical nature. We propose to interpret these low-multipole soft modes as a new cosmological-frame ambiguity that needs to be fixed prior to evaluating cosmological observables. Second, we demonstrate that the adiabatic cosmological perturbations generated by LGTs deform but preserve all the explicit and hidden Killing symmetries of the background geometry. As such, long-wavelength modes stand as a concrete example of algebraically-special cosmological perturbations of Petrov-type O, and inherit the conformal group as isometries and a set of four deformed Killing-Yano tensors and their associated Killing tensors. This opens the possibility to study their effect on cosmological observables in a fully analytic manner
