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QSAR analysis of the toxicity of phenols and thiophenols using MLR and ANN
No full textAbstractThis study gives a quantitative structure–activity relationship (QSAR) analysis of toxicity of phenols and thiophenols to Photobacterium phosphoreum, which is an important indicator for water quality. The chemical structures of 51 phenols and thiophenols have been characterized by electronic and physic-chemical descriptors. The present study was performed using principal components analysis (PCA), multiple regression analysis (MLR) and artificial neural network (ANN). The quantitative model was accordingly proposed and the toxicity of the compounds was interpreted based on the multivariate statistical analysis.This study shows that the results obtained by MLR were suitable and have served to predict toxicity, but compared to the results of the ANN model, we conclude that the prediction achieved by the latter is more effective and better than MLR model. The statistical results of the predictive performance indicate that the ANN model is statistically significant than the previous reported model based on CART-LS-SVR. Following to the obtained results, our proposed model may be useful to predict of toxicity and risk assessment of chemicals
The emotional impact of verbal irony: Eye-tracking evidence for a two-stage process
No full textAbstractIn this paper we investigate the socio-emotional functions of verbal irony. Specifically, we use eye-tracking while reading to assess moment-to-moment processing of a character’s emotional response to ironic versus literal criticism. In Experiment 1, participants read stories describing a character being upset following criticism from another character. Results showed that participants initially more easily integrated a hurt response following ironic criticism; but later found it easier to integrate a hurt response following literal criticism. In Experiment 2, characters were instead described as having an amused response, which participants ultimately integrated more easily following ironic criticism. From this we propose a two-stage process of emotional responding to irony: While readers may initially expect a character to be more hurt by ironic than literal criticism, they ultimately rationalize ironic criticism as being less hurtful, and more amusing
Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing
No full textAbstractWhile many individuals can benefit substantially from cochlear implantation, the ability to perceive and understand auditory speech with a cochlear implant (CI) remains highly variable amongst adult recipients. Importantly, auditory performance with a CI cannot be reliably predicted based solely on routinely obtained information regarding clinical characteristics of the CI candidate. This review argues that central factors, notably cortical function and plasticity, should also be considered as important contributors to the observed individual variability in CI outcome. Superior temporal cortex (STC), including auditory association areas, plays a crucial role in the processing of auditory and visual speech information. The current review considers evidence of cortical plasticity within bilateral STC, and how these effects may explain variability in CI outcome. Furthermore, evidence of audio-visual interactions in temporal and occipital cortices is examined, and relation to CI outcome is discussed. To date, longitudinal examination of changes in cortical function and plasticity over the period of rehabilitation with a CI has been restricted by methodological challenges. The application of functional near-infrared spectroscopy (fNIRS) in studying cortical function in CI users is becoming increasingly recognised as a potential solution to these problems. Here we suggest that fNIRS offers a powerful neuroimaging tool to elucidate the relationship between audio-visual interactions, cortical plasticity during deafness and following cochlear implantation, and individual variability in auditory performance with a CI
Realizing the energy potential of forest biomass in Sweden – How much is environmentally sustainable?
No full textAbstractHarvesting of wood for bioenergy purpose will probably increase in importance in the future, in order to replace fossil fuel. However, the environmental impact of increased harvesting might be considerable, e.g. on soil and water chemistry, biodiversity and long-term productivity, and in this study we investigate thresholds for sustainable harvesting volumes. The study is based on scientific reviews of the impact of harvesting of logging residues (slash and stumps) on forest production, biodiversity, acidification, eutrophication and toxic substances. We define sustainability by using environmental objectives decided by the Swedish parliament (which are based on the Aichi targets), and relate the harvesting impact to these objectives within different harvesting scenarios, by using expert judgment. We demonstrate that an increase in harvesting of logging residues by 2.5 times might be sustainable. However, we also identify a number of risks and the sustainability depends on a number of requirements that should be fulfilled, such as ash-recycling. It was found that factors related to biodiversity conservation (defined in the goals ‘Sustainable Forests’ and ‘A Rich Diversity of Plant and Animal Life’) were limiting factors both for slash- and stump harvesting, and that risk of acidification (defined in the goal ‘Natural Acidification Only’) also limit slash harvesting. We also include harvesting of brushwood and energy wood from conservation cutting in the discussion, since these assortments might be important in the future
Navigating the authority paradox: Practising objectivity in environmental expertise
No full textAbstractWe empirically reveal how environmental experts interpret the objectivity norm while navigating the authority paradox. The paradox here is that while there is a need for objective scientific advice, such advice is only to be acquired from experts and expert agencies whose objectivity and, hence, authority are contested. Viewed through the lens of practice, we identify what practitioners at the PBL Netherlands Environmental Assessment Agency understand by objectivity. Using this paradigmatic case, we show how practitioners renegotiate the meaning of objectivity while seeking to engage with new policy actors and extended peers in an independent, rigorous and legitimate manner. Successfully navigating the authority paradox is related to skilfully representing and adapting to various meanings of objectivity. Experts and experts agencies accordingly need reflexive skills to recognise which meanings of objectivity they ascribe to and which ones are invoked in public debates. Environmental experts who are able to loosely connect diverse objectivity conceptions are more likely considered as trustworthy and authoritative partners in environmental science-policy interfaces
Development and stability studies of sunscreen cream formulations containing three photo-protective filters
No full textAbstractThe present study aimed to formulate and subsequently evaluate sunscreen cream (W/O/W emulsion) containing three photo-protective filters: benzophenone-3, ethylhexyl methoxycinnamate and titanium dioxide at different percentages. Formulations were stored at 8, 25 and 40°C for four weeks to investigate their stability. Color, centrifugation, liquefaction, phase separation, pH and Sun Protection Factor (SPF) of sunscreen cream formulations were determined. The microbiological stability of the creams was also evaluated and the organoleptic quality was carried out for 28days. Interestingly, the combination of 7% Benzophenone-3, 7% Ethylhexyl methoxycinnamate and 6% Titanium dioxide preserved physicochemical properties of the product and was efficient against the development of different spoilage microorganisms as well as aerobic plate counts, Pseudomonas aeruginosa, Staphylococcus aureus, and yeast and mold counts. Furthermore, a good stability was observed for all formulations throughout the experimental period. The newly formulated sunscreen cream was proved to exhibit a number of promising properties and attributes that might open new opportunities for the development of more efficient, safe, and cost-effective skin-care, cosmetic, and pharmaceutical products
Liquid hydridosilane precursor prepared from cyclopentasilane via sonication at low temperatures without the action of light
No full textAbstractWe report on a liquid hydridosilane precursor ink prepared via the ultrasonically induced ring-opening polymerisation of cyclopentasilane (Si5H10) without irradiation by ultraviolet light. The sonication is carried out in N2 atmosphere at temperatures between 20 and 75°C. We use size exclusion chromatography (SEC) to show polymer growth and estimate molecular mass with increasing sonication time. In combination with UV–vis transmission measurements, further SEC analysis is used to compare solutions subjected to either purely thermal or ultrasonic treatment at the same process temperature and for the same duration. Our findings provide strong evidence showing that the initiation of the polymerisation is sonocatalytic in nature and not thermic due to the macroscopic temperature of the solution. The liquid precursor is used to produce homogeneous hydrogenated amorphous silicon (a-Si:H) thin films via spin coating and pyrolytic conversion. The optoelectronic properties of the films are subsequently improved by hydrogen radical treatment. Fourier transform infrared spectroscopy (FTIR) is used to determine a compact film morphology and electrical conductivity measurements show that the layers attain a light-to-dark photosensitivity ratio of 2×103 making them suitable for application in optoelectronic devices
Broad ion beam serial section tomography
No full textAbstractHere we examine the potential of serial Broad Ion Beam (BIB) Ar+ ion polishing as an advanced serial section tomography (SST) technique for destructive 3D material characterisation for collecting data from volumes with lateral dimensions significantly greater than 100µm and potentially over millimetre sized areas. Further, the associated low level of damage introduced makes BIB milling very well suited to 3D EBSD acquisition with very high indexing rates. Block face serial sectioning data registration schemes usually assume that the data comprises a series of parallel, planar slices. We quantify the variations in slice thickness and parallelity which can arise when using BIB systems comparing Gatan PECS and Ilion BIB systems for large volume serial sectioning and 3D-EBSD data acquisition. As a test case we obtain 3D morphologies and grain orientations for both phases of a WC-11%wt. Co hardmetal. In our case we have carried out the data acquisition through the manual transfer of the sample between SEM and BIB which is a very slow process (1–2 slice per day), however forthcoming automated procedures will markedly speed up the process. We show that irrespective of the sectioning method raw large area 2D-EBSD maps are affected by distortions and artefacts which affect 3D-EBSD such that quantitative analyses and visualisation can give misleading and erroneous results. Addressing and correcting these issues will offer real benefits when large area (millimetre sized) automated serial section BIBS is developed
Succinimide-N-sulfonic acid: An efficient and recyclable catalyst for the one-pot synthesis of tetrahydrobenzo[c]acridine-8(7H)-one derivatives
No full textAbstractSynthesis of substituted 10,10-dimethyl-7-phenyl-9,10,11,12-tetrahydrobenzo[c]acridin-8(7H)-one derivatives proceeded by the one-pot reaction of aromatic aldehydes, 5,5-dimethylcyclohexane-1,3-dione (dimedone) and 1-naphthylamine, in the presence of Succinimide-N-sulfonic acid (SuSA) has been reported. Simplicity of operation, high yields, easy work-up and a wide range of substrate applicabilities are the key advantages of this methodology. Furthermore, the catalyst can be recovered conveniently and reused efficiently