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Analysis of seven salad rocket (Eruca sativa) accessions: The relationships between sensory attributes and volatile and non-volatile compounds
No full textAbstractSensory and chemical analyses were performed on accessions of rocket (Eruca sativa) to determine phytochemical influences on sensory attributes. A trained panel was used to evaluate leaves, and chemical data were obtained for polyatomic ions, amino acids, sugars and organic acids. These chemical data (and data of glucosinolates, flavonols and headspace volatiles previously reported) were used in Principal Component Analysis (PCA) to determine variables statistically important to sensory traits. Significant differences were observed between samples for polyatomic ion and amino acid concentrations. PCA revealed strong, positive correlations between glucosinolates, isothiocyanates and sulfur compounds with bitterness, mustard, peppery, warming and initial heat mouthfeel traits. The ratio between glucosinolates and sugars inferred reduced perception of bitter aftereffects. We highlight the diversity of E. sativa accessions from a sensory and phytochemical standpoint, and the potential for breeders to create varieties that are nutritionally and sensorially superior to existing ones
Atomic scale processes of phase transformations in nanocrystalline NiTi shape-memory alloys
No full textAbstractMolecular dynamics simulations are performed to investigate temperature- and stress-induced phase transformations in nanocrystalline nickel-titanium shape-memory alloys. Our results provide detailed insights into the origins of the experimentally reported characteristics of phase transformations at the nanoscale, such as the decrease of the transformation temperature with grain size and the disappearance of the plateau in the stress-strain response. The relevant atomic scale processes, such as nucleation, growth, and twinning are analyzed and explained. We suggest that a single, unified mechanism—dominated by the contribution of a local transformation strain—explains the characteristics of both temperature- and stress-induced phase transformations in nanocrystalline nickel-titanium
Estimation for stochastic volatility model: Quasi-likelihood and asymptotic quasi-likelihood approaches
No full textAbstractFor estimation of the stochastic volatility model (SVM), this paper suggests the quasi-likelihood (QL) and asymptotic quasi-likelihood (AQL) methods. The QL approach is quite simple and does not require full knowledge of the likelihood functions of the SVM. The AQL technique is based on the QL method and is used when the covariance matrix Σ is unknown. The AQL approach replaces the true variance–covariance matrix Σ by nonparametric kernel estimator of Σ in QL
Enhancement of corrosion protection effect in mechanochemically synthesized Polyaniline/MMT clay nanocomposites
No full textAbstractNanocomposite material that consists of DBSA (dodecylbenzensulfonic acid) doped polyaniline (PANI) was prepared by solvent free mechanochemical intercalation method. Organic aniline monomer was first intercalated into the interlayer regions of Na-MMT (sodium montmorillonite) clay hosts and followed by one-step oxidative polymerization. The as synthesized polyaniline clay nanocomposites were treated with DBSA to get PANI-DBSA clay nanocomposites. PANI-DBSA clay nanocomposites in the form of coatings at different concentrations of DBSA on C45 steel were found much superior in corrosion protection over those of conventional polyaniline, based on the series of electrochemical measurement of corrosion potential, polarization resistance and corrosion current in 3.5% aqueous NaCl electrolyte. UV–visible spectroscopy, FT-IR and SEM studies confirm the formation of intercalated polyaniline clay nanocomposites inside the clay nanolayers
Hazard tolerance of spatially distributed complex networks
No full textAbstractIn this paper, we present a new methodology for quantifying the reliability of complex systems, using techniques from network graph theory. In recent years, network theory has been applied to many areas of research and has allowed us to gain insight into the behaviour of real systems that would otherwise be difficult or impossible to analyse, for example increasingly complex infrastructure systems. Although this work has made great advances in understanding complex systems, the vast majority of these studies only consider a systems topological reliability and largely ignore their spatial component. It has been shown that the omission of this spatial component can have potentially devastating consequences. In this paper, we propose a number of algorithms for generating a range of synthetic spatial networks with different topological and spatial characteristics and identify real-world networks that share the same characteristics. We assess the influence of nodal location and the spatial distribution of highly connected nodes on hazard tolerance by comparing our generic networks to benchmark networks. We discuss the relevance of these findings for real world networks and show that the combination of topological and spatial configurations renders many real world networks vulnerable to certain spatial hazards
On the link between martian total ozone and potential vorticity
No full textAbstractWe demonstrate for the first time that total ozone in the martian atmosphere is highly correlated with the dynamical tracer, potential vorticity, under certain conditions. The degree of correlation is investigated using a Mars global circulation model including a photochemical model. Potential vorticity is the quantity of choice to explore the dynamical nature of polar vortices because it contains information on winds and temperature in a single scalar variable. The correlation is found to display a distinct seasonal variation, with a strong positive correlation in both northern and southern winter at poleward latitudes in the northern and southern hemisphere respectively.The identified strong correlation implies variations in polar total ozone during winter are predominantly controlled by dynamical processes in these spatio-temporal regions. The weak correlation in northern and southern summer is due to the dominance of photochemical reactions resulting from extended exposure to sunlight. The total ozone/potential vorticity correlation is slightly weaker in southern winter due to topographical variations and the preference for ozone to accumulate in Hellas basin. In northern winter, total ozone can be used to track the polar vortex edge.The ozone/potential vorticity ratio is calculated for both northern and southern winter on Mars for the first time. Using the strong correlation in total ozone and potential vorticity in northern winter inside the polar vortex, it is shown that potential vorticity can be used as a proxy to deduce the distribution of total ozone where satellites cannot observe for the majority of northern winter. Where total ozone observations are available on the fringes of northern winter at poleward latitudes, the strong relationship of total ozone and potential vorticity implies that total ozone anomalies in the surf zone of the northern polar vortex can potentially be used to determine the origin of potential vorticity filaments
Cell membrane modulation as adjuvant in cancer therapy
No full textAbstractCancer is a complex disease involving numerous biological processes, which can exist in parallel, can be complementary, or are engaged when needed and as such can replace each other. This redundancy in possibilities cancer cells have, are fundamental to failure of therapy. However, intrinsic features of tumor cells and tumors as a whole provide also opportunities for therapy. Here we discuss the unique and specific makeup and arrangement of cell membranes of tumor cells and how these may help treatment. Interestingly, knowledge on cell membranes and associated structures is present already for decades, while application of membrane modification and manipulation as part of cancer therapy is lagging. Recent developments of scientific tools concerning lipids and lipid metabolism, opened new and previously unknown aspects of tumor cells and indicate possible differences in lipid composition and membrane function of tumor cells compared to healthy cells. This field, coined Lipidomics, demonstrates the importance of lipid components in cell membrane in several illnesses. Important alterations in cancer, and specially in resistant cancer cells compared to normal cells, opened the door to new therapeutic strategies. Moreover, the ability to modulate membrane components and/or properties has become a reality. Here, developments in cancer-related Lipidomics and strategies to interfere specifically with cancer cell membranes and how these affect cancer treatment are discussed. We hypothesize that combination of lipid or membrane targeted strategies with available care to improve chemotherapy, radiotherapy and immunotherapy will bring the much needed change in treatment in the years to come
Mathematical model of transmission dynamics and optimal control strategies for 2009 A/H1N1 influenza in the Republic of Korea
No full textAbstractA mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention. This quantified reduced transmission rate is used as an upperbound of the nonpharmaceutical control for studying optimal control strategies, which is a new approach for determining the realistic upperbound of control. In this study, we also explore the real-time prediction of incidence using the mathematical model during the early stage of the epidemic. We investigate the impact of vaccination coverage and timing with respect to the cumulative incidence. The result implies that early vaccination plays a significant role for preventing the epidemic
The emergy of metabolism in different ecosystems under the same environmental conditions in the agro-pastoral ecotone of northern China
No full textAbstractThe sustainability of ecosystem productivity and rules governing ecosystem development are important topics of scientific research. The emergy approach is an effective method for investigating these topics, especially when used to evaluate systems that have developed under the same environmental conditions, such as climate and soil. In this paper, emergy differences between terrestrial ecosystems were studied in Guyuan County, a region representative of the agro-pastoral ecotone in Hebei Province, China. A combination of field tests and a questionnaire survey were carried out between June and August 2015. The ecosystems studied included natural grassland, artificial grassland, field crops and commercial crops. These four ecosystems were further subdivided into a total of ten ecosystems. Natural grassland was divided into free-grazing and mowed ecosystems; artificial grassland consisted of oat, Chinese leymus and corn silage; field crops included naked oats, flax and wheat; and commercial crops consisted of cabbage and potatoes. The results showed that the rain input of 4.78×1014seJ/ha/yr constituted the highest renewable natural resource emergy and that the purchased emergy inputs of the ten ecosystems ranged from 3.53 to 147.67×1014seJ/ha/yr. Natural resource emergy input was the basic power to maintain the ecosystem, and purchased emergy input was the direct cause of the development of the ecosystems. Groundwater was the most important non-renewable purchased energy for the production of economic crops. The emergy investment ratios (EIR) for potatoes (27.81) and cabbage (19.03) were higher than those of the other ecosystems, but mowed and artificial Chinese leymus grassland had the higher emergy self-sufficiency rates (ESR). Natural grassland, artificial Chinese leymus grassland and traditional grain crops had a low environmental load and high sustainability, whereas potatoes and cabbage had a high environmental load and low sustainability. Overall, rain-fed artificial grassland has a high development potential from the perspective of environment and productivity
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia
No full textAbstractCurcumin, a curcuminoid from Curcuma longa, presents antioxidant and anti-inflammatory actions and, among pathological changes of cerebral ischemic injury, inflammation is an important one. The objectives were to study the neuroprotective action of curcumin, in a model of global ischemia. Male Wistar rats (sham-operated, ischemic untreated and ischemic treated with curcumin, 25 or 50 mg/kg, p.o.) were anesthesized and their carotid arteries occluded, for 30 min. The SO group had the same procedure, except for carotid occlusion. In the 1st protocol, animals were treated 1 h before ischemia and 24 h later; and in the 2nd protocol, treatments began 1 h before ischemia, continuing for 7 days. Twenty four hours after the last administration, animals were euthanized and measurements for striatal monoamines were performed, at the 1st and 7th days after ischemia, as well as histological and immunohistochemical assays in hippocampi. We showed in both protocols, depletions of DA and its metabolites (DOPAC and HVA), in the ischemic group, but these effects were reversed by curcumin. Additionally, a decrease seen in 5-HT contents, 1 day after ischemia, was also reversed by curcumin. This reversion was not seen 7 days later. On the other hand, a decrease observed in NE levels, at the 7th day, was totally reversed by curcumin. Furthermore, curcumin treatments increased neuronal viability and attenuated the immunoreactivity for COX-2 and TNF-alpha, in the hippocampus in both protocols. We showed that curcumin exerts neuroprotective actions, in a model of brain ischemia that are probably related to its anti-inflammatory activity