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Investigating weaning using dental microwear analysis: A review
No full textAbstractThis paper provides a theoretical review and a framework of methods for using dental microwear analysis on deciduous teeth to investigate weaning processes from archaeological remains, and provides an approach to assess changes in food consumption during weaning. We review the process of weaning, which can be informative of subsistence transitions, maternal labour, demographic factors including birth spacing and infant health, and highlight the relationships between weaning, immune status, and exposure to pathogens. Prior microwear research has largely focused on adults necessitating consideration of the methods concerning deciduous teeth. Microwear can be used to discern between the consistency and fracture properties of food as enamel is removed during mastication, and is influenced by how food is prepared (for example premasticated, raw, cooked). As such, microwear provides a direct way to explore the introduction of complementary foods during weaning. A conceptual model of the potential confounders of assessing microwear in deciduous teeth including tooth biology, bite force, and the development of oral mechanics is presented. These are pertinent to understanding infant feeding, which changes in tandem with physical development and the sequence of dental eruption. This is relevant to future research for the interpretation of the microwear signatures of infants compared with adults. Understanding weaning practices and early life diet is crucial to expand and develop what we know about cultural systems, population health, nutrition, and subsistence practices in the past
Structural change and wife abuse: A disaggregated study of mineral mining and domestic violence in sub-Saharan Africa, 1999–2013
No full textAbstractMineral mining may be a mixed blessing for local communities. On the one hand, extractive industries can be a positive economic driver, generating considerable revenues, and opportunities for growth. On the other hand, mining is often thought to be associated with negative effects, such as pollution, and violent conflict. Existing research has shown that mine openings trigger a structural change in employment patterns in Africa, whereby women shift from agricultural work to the service sector, or leave the labor force. However, few if any systematic studies have addressed whether this structural shift may impact the level of violence within the household. Drawing on various versions of resource theory, we argue that mining – through such structural change – may increase women's risk of being abused by their partners. Recent advances in the literature on domestic violence (DV) suggest that prevailing gender norms moderate effects of resources. We test this empirically by matching georeferenced data on openings and closings of 147 industrial mines to individual data on abuse for up to 142,749 women from the Demographic and Health Surveys in 15 sub-Saharan African countries. We find no overall statistically significant effect of mine openings on the risk of partner abuse, although there are heterogeneous effects across countries. Furthermore, mining is associated with increased DV in areas with higher general acceptance of such abuse
Association of metabolic syndrome with erosive esophagitis and Barrett’s esophagus in a Chinese population
No full textAbstractBackgroundMetabolic syndrome has been highlighted as a risk factor for several gastrointestinal diseases, including gastroesophageal reflux disease and Barrett’s esophagus (BE). The aim of this study was to investigate the association of metabolic syndrome with erosive esophagitis (EE) and BE.MethodsData were retrospectively collected from patients who visited the Medical Screening Center at Taichung Veterans General Hospital, Taichung, Taiwan from January 2006 to December 2009. All patients underwent an open-access transoral upper gastrointestinal endoscopy, and serum laboratory data were collected. The exclusion criteria included prior gastric surgery, or presence of esophageal varices or peptic ulcers. These patients were assigned to groups according to their endoscopic findings as follows: (1) normal group; (2) EE group; and (3) BE group. Metabolic syndrome was diagnosed based on the International Diabetes Federation criteria.ResultsThere were 560/6499 (8.6%) patients, 214/1118 (9.6%) patients, and 19/95 (20%) patients with metabolic syndrome in the normal, EE, and BE groups, respectively. There was a significantly higher percentage of cases with hypertriglyceridemia in the EE group (67%) compared with the other groups. The BE group had significantly higher rates of central obesity (33%) and hypertension (29.5%) compared with rates in the normal and EE groups. After adjusting for confounders, the positive association with metabolic syndrome still existed in both the EE group (adjusted odds ratio=2.43; 95% confidence interval=1.02–3.44) and the BE group (adjusted odds ratio=2.82; 95% confidence interval=2.05–3.88).ConclusionOur research indicated that in fact there is a greater risk of concurrent metabolic syndrome in patients with EE or BE
Asymmetrical transfer effects of cognitive bias modification: Modifying attention to threat influences interpretation of emotional ambiguity, but not vice versa
No full textAbstractBackground and objectivesIt is well established that attention bias and interpretation bias each have a key role in the development and continuation of anxiety. How the biases may interact with one another in anxiety is, however, poorly understood. Using cognitive bias modification techniques, the present study examined whether training a more positive interpretation bias or attention bias resulted in transfer of effects to the untrained cognitive domain. Differences in anxiety reactivity to a real-world stressor were also assessed.MethodsNinety-seven first year undergraduates who had self-reported anxiety were allocated to one of four groups: attention bias training (n = 24), interpretation bias training (n = 26), control task training (n = 25) and no training (n = 22). Training was computer-based and comprised eight sessions over four weeks. Baseline and follow-up measures of attention and interpretation bias, anxiety and depression were taken.ResultsA significant reduction in threat-related attention bias and an increase in positive interpretation bias occurred in the attention bias training group. The interpretation bias training group did not exhibit a significant change in attention bias, only interpretation bias. The effect of attention bias training on interpretation bias was significant as compared with the two control groups. There were no effects on self-report measures.LimitationsThe extent to which interpretive training can modify attentional processing remains unclear.ConclusionsFindings support the idea that attentional training might have broad cognitive consequences, impacting downstream on interpretive bias. However, they do not fully support a common mechanism hypothesis, as interpretive training did not impact on attentional bias
A Randomized Controlled Multicenter US Food and Drug Administration Trial of the Safety and Efficacy of the Minerva Endometrial Ablation System: One-Year Follow-Up Results
No full textAbstractStudy ObjectiveTo assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in premenopausal women.DesignMulticenter, randomized, controlled, international study (Canadian Task Force classification I).SettingThirteen academic and private medical centers.PatientsPremenopausal women (n = 153) suffering from heavy menstrual bleeding (PALM-COEIN: E, O).InterventionPatients were treated using the Minerva Endometrial Ablation System or rollerball ablation.Measurements and Main ResultsAt 1-year post-treatment, study success (alkaline hematin ≤80 mL) was observed in 93.1% of Minerva subjects and 80.4% of rollerball subjects with amenorrhea reported by 71.6% and 49% of subjects, respectively. The mean procedure times were 3.1 minutes for Minerva and 17.2 minutes for rollerball. There were no intraoperative adverse events and/or complications reported.ConclusionThe results of this multicenter randomized controlled trial demonstrate that at the 12-month follow-up, the Minerva procedure produces statistically significantly higher rates of success, amenorrhea, and patient satisfaction as well as a shorter procedure time when compared with the historic criterion standard of rollerball ablation. Safety results were excellent and similar for both procedures
Modulation of precipitation by conditional symmetric instability release
No full textAbstractAlthough many theoretical and observational studies have investigated the mechanism of conditional symmetric instability (CSI) release and associated it with mesoscale atmospheric phenomena such as frontal precipitation bands, cloud heads in rapidly developing extratropical cyclones and sting jets, its climatology and contribution to precipitation have not been extensively documented. The aim of this paper is to quantify the contribution of CSI release, yielding slantwise convection, to climatological precipitation accumulations for the North Atlantic and western Europe. Case studies reveal that CSI release could be common along cold fronts of mature extratropical cyclones and the North Atlantic storm track is found to be a region with large CSI according to two independent CSI metrics. Correlations of CSI with accumulated precipitation are also large in this region and CSI release is inferred to be occurring about 20% of the total time over depths of over 1 km. We conclude that the inability of current global weather forecast and climate prediction models to represent CSI release (due to insufficient resolution yet lack of subgrid parametrization schemes) may lead to errors in precipitation distributions, particularly in the region of the North Atlantic storm track
Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
No full textAbstractObjectiveEvidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor necrosis factor α in children with Down syndrome.MethodsEighty-six children (5–8 years of age) were enrolled in this case-control study from two public institutions. At the time of sampling, the patients and controls suffered from no acute or chronic illnesses and received no therapies or supplements. The levels of interleukin 6, tumor necrosis factor α, coenzyme Q10, fasting blood glucose, and intelligence quotient were measured.ResultsForty-three young Down syndrome children and forty-three controls were included over a period of eight months (January–August 2014). Compared with the control group, the Down syndrome patients showed significant increase in interleukin 6 and tumor necrosis factor α (p=0.002), while coenzyme Q10 was significantly decreased (p=0.002). Also, body mass index and fasting blood glucose were significantly increased in patients. There was a significantly positive correlation between coenzyme Q10 and intelligence quotient levels, as well as between interleukin 6 and tumor necrosis factor α.ConclusionInterleukin 6 and tumor necrosis factor α levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms
Dataset of the absorption, emission and excitation spectra and fluorescence intensity graphs of fluorescent cyanine dyes for the quantification of low amounts of dsDNA
No full textAbstractThis article describes data related to a research article entitled “Fluorescent cyanine dyes for the quantification of low amounts of dsDNA” (B. Bruijns, R. Tiggelaar, J. Gardeniers, 2016) [1]. Six cyanine dsDNA dyes - EvaGreen, SYBR Green, PicoGreen, AccuClear, AccuBlue NextGen and YOYO-1 – are investigated and in this article the absorption spectra, as well as excitation and emission spectra, for all six researched cyanine dyes are given, all recorded under exactly identical experimental conditions. The intensity graphs, with the relative fluorescence in the presence of low amounts of dsDNA, are also provided
On the linearization of nonlinear supersymmetry based on the commutator algebra
No full textAbstractWe discuss a linearization procedure of nonlinear supersymmetry (NLSUSY) based on the closure of the commutator algebra for variations of functionals of Nambu–Goldstone fermions and their derivative terms under NLSUSY transformations in Volkov–Akulov NLSUSY theory. In the case of a set of bosonic and fermionic functionals, which leads to (massless) vector linear supermultiplets, we explicitly show that general linear SUSY transformations of basic components defined from those functionals are uniquely determined by examining the commutation relation in the NLSUSY theory
From the Medical Board of the National Psoriasis Foundation: Treatment targets for plaque psoriasis
No full textBackgroundAn urgent need exists in the United States to establish treatment goals in psoriasis.ObjectiveWe aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice.MethodsThe National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds.ResultsA total of 25 psoriasis experts participated in the Delphi process. The most preferred instrument was body surface area (BSA). The most preferred time for evaluating patient response after starting new therapies was at 3 months. The acceptable response at 3 months postinitiation was either BSA 3% or less or BSA improvement 75% or more from baseline. The target response at 3 months postinitiation was BSA 1% or less. During the maintenance period, evaluation every 6 months was most preferred. The target response at every 6 months maintenance evaluation is BSA 1% or less.LimitationsAlthough BSA is feasible in practice, it does not encompass health-related quality of life, costs, and risks of side effects.ConclusionWith defined treatment targets, clinicians and patients can regularly evaluate treatment responses and perform benefit-risk assessments of therapeutic options individualized to the patient