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One man gives another man a haircut
No full textOne man gives another man a haircut outside of their home
Creating Requirements: Emerging Military Capabilities, Civilian Preferences, and Civil-Military Relations
No full textThis dissertation explores the relationship between civilian and military preferences in the United States. A standard measure of the health of the civil-military relationship is whether civilian preferences prevail over military preferences in times of disagreement. Generally, the civil-military relations literature focuses on civilian efforts to impose their preferences on the military. But is it possible that the military is able to impose its preferences on civilians as well? This study asks and answers the questions: Does the military shape civilian preferences, and to what extent? If the military does shape civilian preferences, under what conditions does it do so? I contend that both purposeful actions by the military and factors natural to the civil-military relationship, each centered on the distribution of information resources, shape civilian preferences. I hypothesize that the less information civilians possess relative to the military, the more civilian preferences are based on military preferences. In three cases of emerging military capabilities, I find support for this hypothesis. Using comparative historical methods and process tracing, I examine the congruence of civilian and military preferences across time and find that military actors frequently framed and constrained civilian thinking about, and in some contexts dictated the purposes of, special operations forces, unmanned aerial vehicles, and cyber capabilities.Military studiesInternational relationsPolitical sciencecivil-military relations, civilian control, defense, military history, military innovation, preferencesSchool of International ServiceDegree Awarded: Ph.D. School of International Service. American Universit
Metamodern Monstrosity: Horror Cinema in the 21st Century
No full textHorror is an ever-changing beast, and, like any organism, has evolved in stages. Put simply, these stages are classical, postmodern, and, as will be argued in great detail, metamodern. Classical horror constructs the human/monster binary, showing a glimpse of another way of living but ultimately forecloses alternative structures for society by defeating the monster; postmodern horror deconstructs the human/monster binary by demonstrating the monstrosity of human beings and, by extension, society, which in turn allows substantive change for society but is unable to construct anything new from what it has deconstructed; while metamodern horror reconstructs the human/monster binary by revealing the of the monstrosity of humans, like postmodern horror, and by recognizing of the humanity of the monstrous, which allows for both the breakdown of the status quo and the reconstitution of something grander from its fragments in one stroke. In this way, the human/monster dyad is deconstructed then reconstructed as a hybrid, chimera, and new species: the human-monster—putting the slasher victim, the Subject, back together again using the mutilated pieces of the monster, the Abject
Couple wearing face masks
No full textCouple wearing face masks embraces and kisses through their masks
Characterizing the Role of K19 in Maintaining the Structural Integrity of Breast Cancer Cells
No full textEpithelial to mesenchymal transition is associated with an initial stage of tumor metastasis when cells lose cell-cell adhesion and expression of epithelial markers such as keratin intermediate filament proteins. Keratins are critical for the shape and mechanical integrity of epithelial cells. Among different keratins, Keratin 19 (K19) is highly expressed in various types of cancer including breast cancer and is correlated with a worse patient prognosis. Consistently, K19 expression has been reported to be significantly higher in metastatic breast cancer tumor cells compared to primary tumors. Although knocking down K19 in breast cancer cells increased cell migration, recent studies have shown that increased levels of some keratins can also have a positive impact on metastasis, in part by enabling cells to invade the extracellular matrix collectively. The role of K19 on mechanical properties of cancer cells for cell migration and possible impact on metastasis in breast cancer patients is still unknown. Using K19 knockout (KO) cells in our lab, we found that K19 plays a role in maintaining epithelial cell shape and tight cell-cell adhesion of MCF7 breast cancer cells. Moreover, K19 ablation increased the migratory potential but decreased survival potential of MCF7 cells. At the molecular level, E-cadherin was surprisingly found to be overexpressed in KRT19 KO cells. However, we found that E-cadherin binding to β-catenin decreased in K19 KO cells that have less membrane-E-cadherin. Moreover, E-cadherin was found to be accumulated and internalized in early and recycling endocytic compartments in KRT19 KO cells. Inhibiting internalization of cell surface proteins restored cell-cell adhesion of KRT19 KO cells, suggesting that internalization of E-cadherin contributes to defective cell-cell adhesion. Ultimately, while K19 inhibited cell migration, it was required for cells to form colonies in suspension. Our results suggest that K19 stabilizes E-cadherin complexes at the cell membrane to maintain rounded shape and tight cell-cell adhesion and this adhesion inhibits cell migration but provides growth and survival advantages for circulating tumor cells. These findings provide context-dependent roles of K19 during metastasis.Cellular biologyMolecular biologyBioengineeringadherens junction, breast cancer metastasis, cell adhesion, cell migration, cell morphology, keratin intermediate filamentsBiologyDegree Awarded: Ph.D. Biology. The Catholic University of Americ
Boarded-up window at the J.Crew- The Men's Shop store
No full textThe window beneath the 'J. Crew The Men's Shop' is boarded with wood painted white, blue, and red. A stop sign is shown in front of the white-painted building
View of people crossing a street
No full textThis black and white photo depicts three people crossing 6th Street NW. One person wears a mask and carries a Macy's bag, another person carries two bags, and a person jogs in the opposite direction
The Economic Pathways of Female Vietnamese American Refugees and Migrants
No full textBetween 1975 and 2017, nearly two million members of the Vietnamese diaspora settled in the United States after fleeing war, the Vietnamese Communist regime, and seeking increased freedom and economic opportunities. More than half of these were women. This thesis fills a gap in the literature by viewing female Vietnamese American refugees through a lens of self-agency and by describing their economic pathways in both Vietnam and the United States. Nineteen semi-structured interviews and two group interactions were conducted in 2019 by the author in Houston, Texas. A qualitative review was conducted of the emergent themes from the narratives. Important facets of personal economic development in female Vietnamese American refugees and migrants appeared to be education/training, coping with discrimination, availability of an ethnic niche, and family support. These results may prove useful in both NGOs and government agencies working towards improving the economic outcomes of adult, female refugees.International relationseconomic, employment, migrant, refugee, Vietnam, womenSchool of International ServiceDegree Awarded: M.A. School of International Service. American Universit