Washington Research Library Consortium - Digital Collections
Not a member yet
125665 research outputs found
Sort by
"It's A Small World" 2019 Image 04
No full textThe Humanities Truck parked outside the Petworth Neighborhood Branch of the DC Public Library
"It's A Small World" 2019 Image 15
No full textCommunity history documentation compiled by Peter Stebbins for "It's A Small World" in the Petworth Neighborhood Branch of the DC Public Library
"It's A Small World" 2019 Image 17
No full textPeter Stebbins, Angie Whitehurst, and Carmen Bolt pose for a picture during the "It's A Small World" event
DESIGN AND SYNTHESIS OF NOVEL LCAT AND LPL MODULATORS
No full textFragment-based lead discovery has emerged over the past two decades as a successful approach to generate novel lead candidates in drug discovery programs.2 It is now recognized as a tangible alternative to more traditional methods of hit identification, such as high throughput screening (HTS).1 The two main advantages over conventional HTS are more efficient sampling of chemical space and tighter control over the physicochemical properties of the lead candidates.2 Lipoprotein lipase (LPL) is an enzyme that catalyzes the release of free fatty acids (FFA) from triglyceride (TG)-rich lipoproteins. LPL contributes in a pronounced way to normal lipoprotein metabolism, tissue-specific substrate delivery and utilization, and the many aspects of obesity and other metabolic disorders that relate to energy balance, insulin action, and body weight regulation.4 LPL also plays a role in the brain through the differentiation of neurons in vivo, regeneration of neuronal processes, and memory and cognition.8 Increasing the activation efficacy of the LPL enzyme through small-molecule modulators that can potentially increase HDL levels and lower TGs in the body and brain. There are currently two known LPL enzyme modulators. Compound NO-1886 was found to be an inducer of LPL gene expression (not a direct modulator) in the adipose tissue leading to increased post-heparin plasma LPL activity, lower plasma triglycerides, and higher plasma HDL.13 The second compound, C10d, had its LPL modulation effects compared with NO-1886 and found that C10d exhibited twice the stimulation of LPL than NO-1886 did at equivalent doses and only affected the enzymatic activity of LPL.6 Using fragment ligand designs and starting in our laboratory with a set of synthesized low-molecular weight LCAT enzyme activators, we have designed and prepared a library of novel, small molecule modulators of the LPL enzyme.Organic chemistryNeurosciencesMedicinedesign, enzyme, LCAT, LPL, modulator, synthesisPsychologyDegree Awarded: Ph.D. Psychology. American Universit
THE EXAMINATION OF COGNITIVE MODELS OF SAD: AN ANALYSIS OF UNIQUE PREDICTORS IN A SOCIAL ANXIETY CHALLENGE
No full textThe current study aimed to examine unique predictors of a socially anxious response in a social anxiety challenge, using the cognitive models of social anxiety and previous research as reference. The fundamental question this study hoped to elucidate was what was contributing to changes that occurred in anxiety ratings from baseline to being informed of a speech task. This study examined individuals’ somatic and cognitive responses in social situations, concerns pertaining to both positive and negative evaluation by others, individuals’ perceptions of self as compared to others, self-monitoring, and safety behaviors. The hypothesized models were not supported by the data, as statistically significant findings were not found. While the hypothesized models were not supported by the findings, post-hoc exploratory analyses yielded statistically significant correlations between the various components of the cognitive model (i.e., social comparison was negatively correlated with reported anxiety and fear of positive and negative evaluation; safety behavior was positively correlated with anxious response and fear of negative and positive evaluation). Limitations concerning instrument selection, the experimental manipulation, implications related to recruitment and pre-screening, and considerations for future studies are further addressed in the discussion section.PsychologyCognitive Models, Predictors, Social Anxiety, Social Anxiety ChallengePsychologyDegree Awarded: Ph.D. Psychology. American Universit
You're upset and need my help! The need to regulate your partner's emotions and daily life correlates
No full textRomantic partners often engage in natural affect coregulation where each partner’s emotional state can attenuate or amplify the other’s emotion. Furthermore, negative mood regulation expectancies may be an indicator of romantic relationship functioning. But what happens when one partner believes that it is their role to regulate their partner’s emotions? Expectancies about a romantic partner’s ability to cope with negative emotions may influence individual emotion outcomes. The current research examines these expectancies and how they impact daily emotion processes. Eighty-four adult couples completed baseline personality measures including questions about their expectations of the effort required and their need to intervene to help regulate their partner’s emotions (Partner Emotion Regulation Responsibility Questionnaire: PERRQ). Over three weeks, partners completed evening surveys which included reports of personal affect and perceptions of their partner’s affect. Participants' PERRQ scores were correlated with inaccuracies in recognizing negative affect in their partner. PERQ scores also moderated the relationship between partner’s negative affect and the participant’s self-reported anxious mood, with high PERQ scorers reporting higher anxiety. In other words, as participants endorsed a stronger need to intervene in their partner’s emotional state, they were more likely to detect negative affect when it was absent, less likely to perceive a true lack of negative affect, and experienced a sharper increase in anxious mood when they perceived their partner to be in a bad mood. PERQ scores remained a significant moderator of this relationship even when controlling for neuroticism, difficulties in emotion regulation (for self or partner) and trait anxiety.Clinical psychologydaily diary, emotion regulation, romantic couplesPsychologyDegree Awarded: Ph.D. Psychology. American Universit
Prison Choirs and Choirs for Those Experiencing Homelessness: Landscape and Social Justice Impact in the United States
No full textThis study provides an overview of prison choirs and choirs for those experiencing homelessness in the United States: where these types of groups exist, defining the work they’re doing with the populations mentioned, and identifying both the best practices and major challenges these types of groups face. Additionally, this study discusses the impact these types of groups have had on their members and surrounding communities in the following areas: social justice, education, and health and rehabilitation. This study began with a comprehensive literature review focused on social capital development in choirs. The fieldwork first identified choirs by tracking online presence and includes interviews with directors of both prison choirs and choirs for those experiencing homelessness. Overall, the work of these two types of choirs contribute to the area of social justice through community cohesion, community building and empowerment, and political activation.Arts managementPerforming ArtsDegree Awarded: M.A. Performing Arts. American Universit
A Seat at the Table: Immigrant Businesses and Placemaking
No full textThis dissertation argues that immigrant entrepreneurs creatively repurpose elements of neoliberal programs of improvement, designed to bolster entrepreneurial activity, to carve out a space for themselves (literally and figuratively) through informal social and spatial practices. It examines the everyday, placemaking practices of immigrant-run businesses in the suburban areas of Takoma Park, MD, Mount Rainier, MD and Falls Church, Virginia. Placemaking is defined as the way in which people imbue spaces with social and cultural meaning. Using informality and placemaking theories, the dissertation explores how subversions of neoliberal market logics are a means of placemaking. It offers ethnographic accounts of variety stores, a farmers market, and microlending and training programs. In doing so, it articulates a variety of space imaginaries and posits placemaking as a negotiation between home cultures, particular social contexts, and greater structural forces.Cultural anthropologybusiness, immigrant, informality, microlending, placemaking, washington dcAnthropologyDegree Awarded: Ph.D. Anthropology. American Universit
HUMAN ZOO
No full textThe enclosed work an excerpt of my historical novel-in-progress, Human Zoo, which began as a response to Austrian author Peter Altenberg’s account of an ethnographic exhibition featuring people from Ashantiland (now Ghana). This work of fiction was based on true events: from July to October of 1896, seventy Africans lived on display in huts at the zoo in Vienna’s famous Prater amusement park.As an African-American woman, I had a difficult time getting through Altenberg’s account, written from the perspective of a white male voyeur obsessed with the women and girls in the show. I kept telling myself I was missing something. The Ashanti weren’t portrayed as prisoners. They weren’t locked in cages or chained, and they appeared to have open conversations with Altenberg, who bought his proximity to these young girls in exchange for strings of cut-glass beads. I wanted to understand what would compel the Ashanti to submit to being ogled in zoos so far away from home.I began digging into historical records, and more I researched, the more stories of agency, imagination, and resilience I found in the Ashantis’ journey from their forest kingdom to the capitals of nineteenth-century Europe. This manuscript is part of my attempt to tell another side of the story, particularly (but not exclusively) from the Ashanti women’s perspective. Through this work I explore the granular realities of humans on display, as well as larger questions of culture clash and gender norms, individual agency vs. community demands, and pragmatism vs. complicity in (self-) exploitation.Creative writingASHANTI, ETHNOGRAPHIC, FICTION, HISTORICAL, NOVELLiteratureDegree Awarded: M.F.A. Literature. American Universit