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Projet de recherche doctorale en géographie du développement : ONG, éducation et développement local en Indonésie
No full textInternational audienc
Utility of CA125 KELIM in predicting benefit from hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer: pooled analysis of KGOG3042 and KOV-HIPEC-01
No full textInternational audienc
Are There Differences in Ankle Mechanics After Total Ankle Arthroplasty in Patients Suffering From Post-fracture vs Post-sprain End-Stage Ankle Osteoarthritis?
No full textInternational audienceBackground: To our knowledge, no study is available comparing the change in ankle mechanics during gait after total ankle arthroplasty (TAA) based on the origin of the osteoarthritis. As the nature of trauma is different in patients sustaining post-fracture ankle osteoarthritis (PFOA) from those sustaining post-sprain ankle osteoarthritis (PSOA), it could be expected that the outcomes of TAA, in terms of ankle mechanics during gait, would be different in the 2 groups. A prospective matched comparative study was therefore performed to investigate whether patients sustaining PFOA had different outcomes in terms of changes to ankle mechanics during gait (before surgery vs 1 year after surgery), compared with patients sustaining PSOA. Methods: Fifteen patients with PFOA and 15 patients with PSOA scheduled for primary TAA for pain relief were recruited and peer-matched based on their demographic and spatiotemporal data. All patients underwent a 3D gait analysis before and after surgery, during which a kinematic and kinetic multi-segment foot model was used to quantify inter-segmental joint kinematics and kinetics. Results: The PFOA group exhibited significantly lesser pre- vs postoperative increases in ankle (Shank-Calcaneus) joint peak power, and ankle (Shank-Calcaneus) joint work after TAA compared with the PSOA group. Furthermore, the results demonstrated a trend toward greater increases in peak ankle (Shank-Calcaneus) joint plantarflexion moment and in negative ankle (Shank-Calcaneus) joint work for the PSOA group compared with the PFOA group. Conclusion: This study suggests that patients sustaining PFOA have smaller pre- to postoperative gains in ankle (Shank-Calcaneus) joint power and ankle (Shank-Calcaneus) joint work during gait after TAA compared with patients sustaining PSOA, with modest between-group effects. Although evidence in TAA is lacking, insights from knee replacement suggest prehabilitation and nutritional support may mitigate deficits, representing a potentially essential strategy for PFOA patients requiring further validation
Experimental study on triaxial fatigue properties of mudstone interlayers in CAES under synergistic effects of stress amplitude and time interval
No full textInternational audienc
Performance of the front-end electronics of the CMS electromagnetic calorimeter barrel for the High-Luminosity LHC
No full textInternational audienceThe performance of the CMS electromagnetic calorimeter upgraded readout electronics, developed for the High-Luminosity phase of the LHC, is discussed. Data collected in two beam test campaigns conducted in 2018 and 2021 at the H4 and H2 beam lines of the CERN SPS are analyzed. Time and energy resolutions are measured on a matrix of lead tungstate crystals equipped with prototypes of the new front end readout electronics, using electron and pion beams of energies spanning from 25 to 250 GeV. In both campaigns the constant term of the energy resolution is measured to be better than 0.6% and the time resolution for electrons with energies above 50 GeV is measured to be better than 30 ps, fulfilling the design requirements
Radiobiology Contributions and Perspectives in Hadron Therapy, with a focus on carbon ions: Report from the workshop Hadron therapy for life, Caen, March 2025
No full textISTCTInternational audienceThe "Hadrontherapy for Life" symposium in Caen, France highlighted that a new era of radiobiology is fundamental for advancing particle therapy to the next level. A radiobiology capable of integrating molecular biology and omics technologies is needed to deeply analyze treatment responses and underlying mechanisms.Key challenges discussed at the symposium included tumor hypoxia, which remains only partially mitigated by high-LET radiation, and the specificity of carbon ions, or more broadly, high LET particles, considered as "new drugs" capable of providing systemic benefits beyond local tumor control, including their potential to promote immunogenicity. Moreover, emerging modalities, such as Ultra High Dose Rate irradiation, and spatial fractionated beam were also discussed, with consensus that all require dedicated and coordinated radiobiological investigations.Infrastructure presentations highlighted the international capabilities of leading centers in Europe and Asia, emphasizing the importance of integrating radiobiology into clinical programs, advancing multi-ion experimentation, and adopting innovative experimental models, such as organoids and/or 3D cell cultures. Participants also stressed the need for greater access to animal experimentation facilities, which are essential for accelerating progress in the field. Furthermore, the meeting underscored translational endpoints such as biomarker development, a hot topic in current radiotherapy. The C400 accelerator enables Caen to incorporate radiobiology from its very inception, establishing a European hub for collaborative research. Round-table discussions emphasized the importance of harmonized protocols, dedicated in vivo irradiation rooms, international training programs with exchange of students and researchers, and comprehensive patient biobanking.In summary, the symposium reinforced the essential role of radiobiology in advancing hadrontherapy (HT), providing strategic directions for translational research, infrastructure development, and international collaborations to accelerate personalized and effective particle therapy
Blockchain traceability valuation for perishable agricultural products: Balancing economic benefit and social impact
No full textInternational audienceThe adoption of blockchain-enabled traceability systems in agricultural supply chains offers farmers a means to reduce demand uncertainty. However, downstream retailers gain full visibility into product freshness, enabling selective purchases that may inadvertently increase food waste. This study evaluates the impact of such a traceability system by analyzing agricultural supply chain transactions under two scenarios: with and without blockchain implementation. By comparing order quantities and farmer profits in both cases, we find that blockchain adoption can enhance product sales because the smart contract effect. We also find that blockchain adoption can either amplify the bullwhip effect when circulation time is short or mitigate it when circulation time is long. The interaction between the bullwhip effect and the smart contract effect impacts the farmer’s profit. The farmer achieves higher profits using the blockchain-enabled traceability system if the smart contract effect outweighs the bullwhip effect. Furthermore, adoption costs play a crucial role in determining feasibility. Beyond economic implications, blockchain-enabled traceability systems also influence social outcomes, particularly in reducing food waste. Our analysis reveals four possible outcomes based on economic benefits and social impact: (i) win-win (higher profits and reduced waste), (ii) win-lose (higher profits but increased waste), (iii) lose-win (lower profits but reduced waste), and (iv) lose-lose (lower profits and increased waste). The likelihood of each outcome is strongly dependent on product shelf life—longer shelf life increases the probability of a win-lose scenario, while shorter shelf life raises the likelihood of a lose-win outcome. Win-win and lose-lose scenarios remain the least probable
(Male) Wages in Switzerland, 1750-1860
No full textWe estimate daily wage rates for skilled and unskilled construction workers and agricultural laborers in Switzerland from 1750 to 1860, a period of profound political and economic transformations. Our analysis is based on 17,700 newly collected wage quotes from primary sources and 23,300 price quotes from primary and secondary sources. We find that wages and prices were remarkably similar among different Swiss regions. We therefore construct price and wage series for the entire territory. Nominal wages remained largely unchanged during the second half of the eighteenth century, rose markedly around 1800 and then held at that level until 1850. Real wages stagnated as a result of rising price levels. Contrary to earlier claims of low Swiss wages, wages in the construction sector were similar to those in neighboring European regions, in particular France and Germany. We quantify the uncertainty in our wage estimates that arises from sampling uncertainty and potentially undocumented in-kind benefits
Neonatal hypothyroidism in male mice is associated to developmental delay and metabolic dysregulations in the adult
No full textThe postnatal period of mouse development is critical for the maturation of many organs and fine tuning of hormonal feedback loops. These developmental transformations are necessary to allow the transition from a suckling pup to an independent life but they also determine the metabolic features of the adult. Thyroid hormones are key hormones that control these postnatal events. However, the impact of a short-term exposure to maternal hypothyroidism during the perinatal period on the metabolic outcome of the descendants was not clearly established. We used a new protocol to obtain animals exposed to maternal hypothyroidism only during gestation or only during their two first postnatal weeks. The developmental and the long-term consequences of these two short perinatal periods of hypothyroidism were assessed. Animals born from hypothyroid mothers did not show developmental delays. As adults they were undisguisable from the controls and could adequately face metabolic stresses such as exposure to a high fat diet or cold temperature. In contrast pups exposed to maternal hypothyroidism during lactation presented delayed growth and remained leaner than the controls. The expression of genes involved in different metabolic pathways in liver or brown adipose tissues were affected both during development and in adults. The adults were also more sensitive to diet induced obesity and to cold exposure. In conclusion in mice severe hypothyroidism in the pregnant dam is not detrimental for postnatal development or metabolic programing of the pups. In contrast postnatal hypothyroidism leads to developmental delays and long-lasting metabolic dysregulation in otherwise euthyroid animals
