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Autour du Monasticon Gallicanum : représentation de l'architecture monastique dans la France du XVIIe siècle
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Le Conseil d'Etat juge que les dispositions de la doctrine administrative écrite qui excluent qu'une moins-value de cession de titres de société assujettie à l'impôt sur les sociétés puisse s'imputer sur une plus-value constatée lors de l'apport antérieur d'une entreprise individuelle à une société, dont le report d'imposition a expiré en raison de la cession des titres concernés, ne sont pas contraires à la loi et que ce régime d'imposition ne contrevient pas aux dispositions de l'article 14 de la Convention européenne des droits de l'homme ainsi que de l'article 1er du premier protocole additionnel à celle-ci.
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Comparative endocranial anatomy in the crocodylians Leidyosuchus canadensis and Stangerochampsa mccabei from the upper Cretaceous of Alberta, Canada
No full textInternational audienceAbstract Crocodylians evolved a high variety of rostral morphologies during their evolutionary history, highlighting the strong links between morphological plasticity and environmental and ecological parameters. Two Late Cretaceous alligatoroids, the mesorostrine Leidyosuchus canadensi s Lambe, 1907, and the brevirostrine Stangerochampsa mccabei Wu et al., 1996, from Alberta, Canada, preserve a large groove‐shaped recess on the posterior part of the maxilla that has not been documented in other alligatoroids. Despite the potential phylogenetic and paleoecological significance of this neurovascular feature, internal and endocranial structures remain under‐explored among stem alligatoroids. The endocranial morphology, including the paratympanic sinus system of Leidyosuchus canadensis and Stangerochampsa mccabei , was compared to those of extant crocodylians and of the extinct alligatoroid Diplocynodon ratelii based on computed tomography data. The Cretaceous alligatoroids share endocranial features, such as a posteroventral neurovascular projection of the labiolateral canal that connects to the groove‐like recess at the posterior edge of the maxilla and a paratympanic sinus system most similar to those of small‐bodied and young extant crocodylians, suggesting that these pedomorphic features may reflect the ancestral crocodylian condition. Future phylogenetic studies should consider internal and endocranial characters alike to improve our understanding on the relationships among crocodylians
Understanding dopaminergic dose reduction following STN-DBS: mediation analysis
No full textInternational audienceBackground Levodopa equivalent dopaminergic dose (LEDD) reduction after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease varies widely. Identifying predictors may guide patient selection and programming. Our objectives were to identify predictors of LEDD reduction and to test whether motor improvement mediates this association. Methods Data from 144 patients treated by STN-DBS were analysed. Predictors of LEDD reduction were selected using the Boruta algorithm, a machine-learning method comparing variable importance to randomised features and then tested in a structural equation model for direct and motor-mediated effects. Results Mean LEDD reduction was 41.7% (±38.2%) and motor improvement was 48.6% (±26.7%) at 1 year. Among the four predictors identified by Boruta, lower baseline LEDD (β=0.39, p=0.001), greater axial impairment (β=−0.25, p=0.003) and higher total volume of tissue activated (β=−0.17, p=0.031) were directly associated with lower LEDD reduction, independent of motor improvement. Sensorimotor STN overlap was not directly linked to LEDD reduction but was positively associated with motor improvement (β=0.34, p=0.001), which showed a trend-level effect on LEDD reduction (β=0.16, p=0.065). The total effect of sensorimotor STN overlap on LEDD reduction was not significant. Discussion Dopaminergic dose reduction after STN-DBS is constrained by preoperative axial symptoms and stimulation spread, independently of motor improvement, while sensorimotor STN overlap improves motor symptoms but not dose reduction. Integrating motor phenotype with anatomical guidance may enhance medication management post DBS
Polydopamine-based molecularly imprinted electrochemical microsensors as a novel quantitative analysis for orthophosphate antiscalant
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When green isn't enough: How AI and compliance reframe energy efficiency for sustainable investment
No full textInternational audienceAs technological advancements, artificial intelligence (AI), and climate change become increasingly intertwined, energy efficiency has emerged as a crucial issue for organizations and public authorities. This research examines how firms can align financial and environmental goals to attract diverse investor groups, focusing on AI-driven energy efficiency strategies. To do so, we use the Economies of Worth framework and explore how investors respond to energy strategies framed by financial or environmental motivations (i.e., market or green worlds), depending on the type of AI adopted and the nature of compliance. Across four experimental studies with 1,500 investors, we find that environmental motivations can reduce investor willingness to invest, mediated by perceived energy efficiency. However, AI implementation and certification mechanisms act as critical boundary conditions that can legitimize environmental strategies and enable compromise between market and green logics. Specifically, coupling environmental motivations with AI for energy efficiency and third-party certification leads to higher investor willingness to invest. This study contributes to sustainable investment research by highlighting the critical role of AI and compliance in building hybrid justifications that can facilitate alignment between environmental and financial priorities in investor decision-making.</div
Blocking Sphingosine 1‐phosphate Metabolism With Fingolimod Prevents the Progression of Vascular Smooth Muscle Cells Calcification in Chronic Kidney Disease
No full textInternational audienceABSTRACT Patients with chronic kidney disease, and particularly those under hemodialysis, are prone to develop cardiovascular complications, mostly due to the exacerbation of vascular calcification. Vascular calcification relies on the transdifferentiation of vascular smooth muscle cells into calcifying cells. Sphingosine 1‐phosphate is a pleiotropic sphingolipid and an important regulator of osteogenesis and the cardiovascular system. Therefore, we explored the role of sphingosine 1‐phosphate metabolism in chronic kidney disease‐derived vascular calcification. Vascular calcification progression in chronic kidney disease and sphingosine 1‐phosphate signaling were examined in calcified vascular smooth muscle cells, in aortic explants, in rats with adenine‐induced chronic kidney disease, as well as in serum from hemodialysis patients. Sphingosine kinase 2 activity and sphingosine 1‐phosphate secretion, under the control of phospholipase D1, were exacerbated in calcified vascular smooth muscle cells. Furthermore, phospholipase D1 knockout mice display significantly less circulating sphingosine 1‐phosphate, supporting intertwined signalization cascades. Overall, sphingosine kinase expression and activity were upregulated in calcified aortic explants and in calcified aortas from rats. Sphingosine 1‐phosphate was increased in the serum of rats with mild vascular calcification. The Food and Drug Administration‐approved immunosuppressant drug fingolimod, a general modulator of S1P metabolism, strongly inhibited calcification in vascular smooth muscle cells and aortic explants. Additionally, fingolimod significantly reduced inflammation, attenuated metabolic syndrome and moderately inhibited aortic calcification in rats. Finally, we demonstrated for the first time that serum sphingosine 1‐phosphate was significantly increased in hemodialysis patients with mild abdominal aortic calcification. Our findings open an unexplored therapeutic option, which is targeting sphingosine 1‐phosphate metabolism, eventually with fingolimod, for the prevention and treatment of vascular calcification in chronic kidney disease patients
Diagonals and algebraicity modulo : a sharper degree bound
No full textTo appear in the Annales scientifiques de l'École normale supérieure. A longer version of this work is available at https://arxiv.org/abs/2306.02640International audienceIn 1984, Deligne proved that for any prime number , the reduction modulo of the diagonal of a multivariate algebraic power series with integer coefficients is algebraic over the field of rational functions with coefficients in . Moreover, he conjectured that the algebraic degrees of these functions should grow at most polynomially in . In this article, we provide a new and elementary proof of Deligne's theorem, which yields the first general polynomial bound on with an explicit and reasonable degree.En 1984, Deligne a montr\'e que pour tout nombre premier~, la r\'eduction modulo de la diagonale d'une s\'erie formelle alg\'ebrique de plusieurs variables \`a coefficients entiers est alg\'ebrique sur le corps des fonctions rationnelles \`a coefficients dans . De plus, il a sugg\'er\'e que les degr\'es d'alg\'ebricit\'e de ces fonctions devaient cro\^itre au plus polynomialement en fonction de . Dans cet article, nous pr\'esentons une nouvelle preuve du th\'eor\`eme de Deligne qui est \'el\'ementaire et permet d'\'etablir la premi\`ere borne g\'en\'erale polynomiale avec un degr\'e raisonnable
LE CORPS PARLANT: PEPPE BARRA, ENTRE LA SCÈNE ET L’ÉCRAN
No full textNous avons rencontré l’artiste Peppe Barra lors de notre venue à Naples en mai 2025.Artiste aux multiples talents, il est l'un des plus grands interprètes de la tradition théâtralenapolitaine. Issu d'une famille d'artistes, il est le fils de Giulio et Concetta Barra, et a hérité,notamment de cette dernière, les fondements de son art interprétatif. Sa voix se distingue parsa virtuosité, qui, dans un jeu de notes aiguës et graves et de timbres variés, donne vie à denombreux personnages. Son art est le cunto, le récit, auquel il se consacre en tant que chanteuret acteur. Il a fait ses débuts au sein de la Nuova Compagnia di Canto Popolare, la troupemusicale qui étudie et réinterprète le répertoire de la chanson populaire napolitaine. Au coursde sa carrière, il a participé à des spectacles marquants de l'histoire du théâtre napolitain de laseconde moitié du XXe siècle, comme La gatta Cenerentola (1976) de Roberto De Simone. Avecsa compagnie, il interprète La Cantata dei pastori, qui est encore souvent représenté aujourd'hui.Essentiellement connu et présenté comme chanteur et acteur, cette rencontre est l’occasion derevenir sur l’aspect cinématographique de sa carrière, encore trop peu mis en avant. Il apourtant tourné sous la direction des plus grands cinéastes, de Corbucci à Cavani en passantpar Benigni et plus récemment Özpetek et donné la réplique à Marcello Mastroianni, Michel Piccoli, Peppino De Filippo, Claudia Cardinale pour ne citer qu’eux1. Télévision, docu-fictionmusical, doublage d’un film d’animation, films commerciaux, films d’auteurs, il embrasse tousles médias et toutes les formes, s’investissant dans chacun corps et âmes sans distinction. PeppeBarra est aussi l'un des derniers représentants de la tradition du masque napolitain, dont leplus célèbre personnage est Pulcinella
Enhancing STEM Tomography via Generative Interpolation of Tilt Series for Nanoparticle Analysis
No full textfffInternational audienceliste mot clef