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A ruthenium terpyridine complex showing stable photocatalytic hydrogen evolution under red light
No full textInternational audienceWe report herein the synthesis of a novel terpyriridine ruthenium( ii ) complex, which shows stable hydrogen photoproduction under red light
Biodegradable Polymeric Delivery Systems of Ruthenium(II) Polypyridyl Complexes for the Treatment of High-Grade Epithelial Ovarian Cancer
No full textInternational audienceThe design of effective nanotherapeutic platforms for cancer treatment remains a significant challenge in the field of medicinal inorganic chemistry. Herein, we report the development of Ru(II)-based nanotherapeutic systems specifically engineered for the treatment of high-grade epithelial ovarian cancer. By covalently conjugating a cytotoxic Ru(II) polypyridyl complex (Ru) to a biodegradable block copolymer composed of PEG and PLA, we achieved high drug loading efficiency, improved aqueous solubility, and controlled drug release. The resulting nanoparticles exhibited optimal physicochemical properties, including uniform size distribution, excellent stability, and efficient cellular uptake, as confirmed by inductively coupled plasma mass spectrometry (ICP-MS). NP1 demonstrated enhanced tumor accumulation and a favorable biodistribution profile in vivo, confirming the effectiveness of the covalent encapsulation strategy using block co-polymers. Although no significant tumor growth inhibition was observed in the challenging patient-derived xenograft (PDX) model, OV54, the results provide valuable insights into the complex interplay between drug release kinetics, tumor biology, and therapeutic response
PVD coatings on open-cell 3D foams for electrochemical applications: A review
No full textInternational audienceThe deposition of functional coatings by Physical Vapor Deposition (PVD) on open-cell 3D foams represents a burgeoning area within material science, especially for electrochemical applications. Due to the novelty of this field and the unique geometry of the foams, the use of PVD on these substrates is a breakthrough innovation for functional material development. However, several challenges remain, e.g. understanding film growth mechanisms on foams, their impact on electrochemical processes, and optimizing the performance of coated foams across various applications through an understanding of the electrochemical phenomena occurring inside and on the surface of the coated foams. This review provides the first thorough overview of the current state-of-the-art in this area and suggests innovative solutions to the challenges encountered. It reports the various properties of films on foams reported in literature, compares the electrochemical performance of PVD-coated foams for Oxygen Evolution Reaction (OER)/Hydrogen Evolution Reaction (HER) catalysis, and energy storage applications, and discusses the mechanisms that explain their performance. Additionally, the review offers an analysis of existing research and introduces a novel numerical methodology, integrating Direct Simulation Monte Carlo (DSMC), Particle-in-Cell Monte Carlo (PICMC), and kinetic Monte Carlo (kMC) techniques to facilitate the characterization of coatings within the foams
Recent Developments in the Use of Metal Complexes in Medicinal Chemistry
No full textInternational audienceMetal complexes have been used in medicine for thousands of years. The field of medicinal inorganic chemistry took a crucial turn in the 1960's with the serendipitous discovery of the anticancer platinum(II) complex cisplatin that is now a workhorse in chemotherapy against cancer. Since then, researchers took note that metal complexes could be employed efficiently as drugs and, consequently, the assessment of the use of metal complexes in medicine has been ever growing. With this mini-review, we look back at the research achieved by our group over the last ten years and present therein some highlights in the design of radioimaging agents and the preparation of new generations of anticancer and antifungal drug candidates for more efficient and targeted therapy
On the Stability of Perfluoroisobutyronitrile in High-Voltage Circuit Breaker: A Computational Study
No full textInternational audience2,3,3,3-Tetrafluoro-2-(trifluoromethyl) propanenitrile, also known as perfluoroisobutyronitrile (CF4-CN), is the main component of the so-called g 3 gas mixture (C 3 F 7 CN-CO 2 -O 2 ), a proven alternative to SF 6 as an insulating gas in high-voltage circuit breakers. In recent years, numerous experimental investigations have been conducted to identify the principal reactions that this mixture undergoes before and during the electric arcing processes. While thanks to these efforts, several products have already been characterized in different possible experimental conditions, a full picture of CF4-CN reactivity in the high-voltage conditions of circuit breakers has yet to be reached. In this paper, we present a computational study based on density functional theory (DFT) that further expands the mapping of the possible chemical reactions of CF4-CN before (hydrolysis) and during (decomposition) electric arcing. Through a careful analysis of all possible reactions paths that includes the structural and energy characterization of reaction intermediates and products, the decomposition of C 3 F 7 CN in the presence of oxygen is evidenced, together with the formation of stable amide derivatives upon hydrolysis. This work allows the unambiguous identification of the most probable reaction paths, in terms of energy, leading to the decomposition products reported experimentally, such as CF 4 , COF 2 , or C 2 F 5 CN, as well as the reactions leading to the amide species that have been observed to form crystals in experimental conditions
Cover Feature: Mechanochemical Approach for Metal‐Free Regioselective C5‐Sulfenylation of Imidazo[2,1‐ b ]Thiazoles (ChemSusChem 16/2025)
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Distinguishing carriers' and lattice's temperatures through photoluminescence analysis
No full textInternational audienceWe report the direct and independent measurement of the lattice and the electrons temperatures in a nanocooler device (asymmetric double-barrier semiconductor heterostructure) at different operating points. Both temperatures are estimated from photoluminescence measurements -the former through the shift of the absorptivity profile, the latter through the shape of the blackbody baseline. The device's cooling feature results from the thermionic extraction of electrons injected in a quantum well through an energy selective barrier. While electrons exhibit a spectacular cooling for resonant injection, the lattice temperature remains essentially unaffected, with a temperature decrease at the resolution limit. Further from resonance, both systems show an identical thermal behavior governed by Joule's heating. The similarities and discrepancies of the temperature profiles illustrate the complex thermal behavior of the system, epitomize the need of reliable thermometry method and showcase the ability of photoluminescence to do so
Challenges in the direct lithiation of spent LFP cathodes: the crucial role of reducing agents
No full textInternational audienceRecycling spent lithium-ion batteries (LIBs) has become essential for mitigating resource shortages and reducing the environmental impact. Especially with the wide use of LiFePO4 cathodes, LIBs have become one of the most attractive batteries owing to their excellent electrochemical performance, long life cycle, safety and abundant availability of component elements. This article reviews the most advanced recycling technology for spent LFP cathodes: direct chemical regeneration. The literature review presented here focuses on the role of reducing agents. The direct recycling methods aim at repairing degraded LFP cathode materials and thereby reducing energy and chemical needs compared with traditional recycling methods, which are hindered by high energy consumption and secondary pollution. These innovations improve battery cycle life, lower energy consumption and production costs and support sustainable resource management. Direct regeneration technologies offer new opportunities to minimise resource waste and environmental pollution, promoting sustainable management of spent LIBs and advancing renewable energy technologies
Controlling Interlayer Disorder Toward Reversible Phase Transition in a Layered Sodium Manganese Oxide Cathode
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Complementary pathways in C–H functionalization of furfural derivatives with cobalt-hydride catalysis
No full textInternational audienceThis study presents a cobalt-catalysed C–H functionalization of furfural derivatives, unveiling substrate-dependent reactivity. Furfurylimines undergo selective C5-alkenylation, while free aldehydes engage in decarbonylative C2-alkenylation