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免疫チェックポイント阻害剤で治療された非小細胞肺がん患者における血漿中Neutrophil Extracellular Trapsの臨床的意義
No full text日本大学博士（医学）doctoral thesi
Effects of Fusobacterium nucleatum on disruption of tight junction in human bronchial epithelial cell layer and mouse lung
No full text日本大学博士（歯学）doctoral thesi
高濃度グルコース条件下がFusobacterium nucleatum接種による血管内皮細胞および気管線維芽細胞の細胞応答性に与える影響
No full text日本大学博士（歯学）doctoral thesi
Development of Peptide Bond Formation Utilizing Novel Dehydrative Condensation Catalyst and Its Application to the Concise Synthesis of Diketopiperazines
No full textPeptide bonds are important chemical linkages constituting many natural products and pharmaceuticals. Although
the dehydrative condensation of the amino acids is the most straightforward approach to construct peptide bonds, the
common methods require a stoichiometric amount of coupling reagents, which causes the problems associated with poor
atom economy and practical operation. In contrast, the catalytic direct dehydrative peptide bond formation is an ideal
approache because water is the only byproduct. This article highlights our recent studies on diboronic acid anhydride
(DBAA)-catalyzed dehydrative peptide bond formations. DBAA designed based on a recent mechanism has been identified as a powerful catalyst for dehydrative condensations of β-hydroxy-α-amino acids, affording the serine, threonine, or
hydroxy valine-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization,
and excellent chemoselectivity. The synthetic utility of the catalysis was demonstrated by the concise synthesis of 2,5-diketopiperazines.departmental bulletin pape
An Investigation of the Conditions at Fort Sam Houston Enemy Alien Detention Station and Experiences of Internees During World War II
Get PDFThis study investigates the role and characteristics of Fort Sam Houston Enemy Alien Detention Station, which operated during World War II in Texas, and examines the experiences of its internees. The United States Army detained enemy aliens on behalf of the Immigration and Naturalization Service (INS) at various posts across the U.S. where the number of apprehensions was so small that it was not feasible for the INS to operate detention facilities in that vicinity. Fort Sam Houston located in San Antonio was one of the two such internment camps in Texas, along with the other being Fort Bliss in El Paso. Fort Sam Houston commenced operations in late February 1942, ceased detaining enemy aliens before the end of 1942, and was subsequently transformed into a prisoner of war camp that housed German POWs until June 1946. Due to limitations of space, this paper only covers the period when the facility detained enemy aliens. This research utilizes materials obtained by the author from the Texas Historical Commission (THC). They disclose to illuminate life and living conditions at this confinement site, along with some information about internees’ experiences. Partly because Fort Sam Houston served as a camp for reassignment, the number of internees fluctuated during ten months of its operation, peaking at 275 individuals and at times, dropping to nearly zero. One contribution of this study is the introduction of forty-seven Japanese who were sent from Hawaii to the mainland U.S. and temporarily interned at this site. The author identified the individuals from the Hawai’i Internee Directory held by the Japanese Cultural Center of Hawai’i (JCCH).departmental bulletin pape
