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Effect of ion-releasing filler-containing gel application on dentin remineralization using optical coherent tomography and ultrasonic velocity measurement
日本大学博士(歯学)doctoral thesi
Fracture strength of implant-supported veneered zirconia crowns with mechanical retentive devices attached to frameworks
日本大学博士(歯学)doctoral thesi
Observation of Granulation Tissue of Tongue Using Synchrotron Radiation
日本大学博士(歯学)doctoral thesi
Analysis of the Intracellular Genomic Binding Region of Nuclear Transport Factor Importin α
A nuclear transport factor of eukaryotes, importin α, transports multiple cargo proteins into the nucleus. Recently,
we have shown that importin α binds directly to DNA. importin α can interact with multiple DNA sequences via
electrostatic interactions and bind to cargo proteins and DNA simultaneously. Therefore, importin α is expected to have
multiple effects on chromatin. However, it is unclear how importin α acts in which genomic regions of cells. In this study,
we investigated the genomic regions to which importin α binds in vivo. Chromatin immunoprecipitation sequencing
(ChIP-seq) analysis showed that importin α binds to multiple genomic regions in the cells. In addition, we tried to
characterize the importin α binding regions by histone post-translational modifications.departmental bulletin pape